{"id":642,"date":"2026-06-02T03:19:37","date_gmt":"2026-06-02T03:19:37","guid":{"rendered":"https:\/\/thuoc115.com\/suckhoe\/?p=642"},"modified":"2026-06-02T03:26:12","modified_gmt":"2026-06-02T03:26:12","slug":"cap-thuoc-cot-loi-trong-dieu-tri-bang-y-hoc-co-truyen-cho-benh-nhan-ung-thu","status":"publish","type":"post","link":"https:\/\/thuoc115.com\/suckhoe\/cap-thuoc-cot-loi-trong-dieu-tri-bang-y-hoc-co-truyen-cho-benh-nhan-ung-thu\/","title":{"rendered":"c\u1eb7p thu\u1ed1c c\u1ed1t l\u00f5i trong \u0111i\u1ec1u tr\u1ecb b\u1eb1ng y h\u1ecdc c\u1ed5 truy\u1ec1n cho b\u1ec7nh nh\u00e2n ung th\u01b0"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c (Traditional Chinese Medicine &#8211; TCM), l\u00e0 lo\u1ea1i h\u00ecnh y h\u1ecdc b\u1ed5 sung v\u00e0 thay th\u1ebf (Complementary and Alternative Medicine &#8211; CAM) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn nh\u1ea5t t\u1ea1i \u0110\u00e0i Loan, ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa. Tuy nhi\u00ean, c\u00e1c nghi\u00ean c\u1ee9u quy m\u00f4 l\u1edbn v\u1ec1 m\u00f4 h\u00ecnh k\u00ea \u0111\u01a1n thu\u1ed1c y h\u1ecdc c\u1ed5 truy\u1ec1n cho b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa v\u1eabn c\u00f2n thi\u1ebfu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M\u1ee5c ti\u00eau c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y l\u00e0 x\u00e1c \u0111\u1ecbnh c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u1ed1t l\u00f5i trong c\u00e1c \u0111\u01a1n thu\u1ed1c y h\u1ecdc c\u1ed5 truy\u1ec1n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa, d\u1ef1a tr\u00ean d\u1eef li\u1ec7u t\u1eeb C\u01a1 s\u1edf d\u1eef li\u1ec7u Nghi\u00ean c\u1ee9u B\u1ea3o hi\u1ec3m Y t\u1ebf Qu\u1ed1c gia \u0110\u00e0i Loan.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c l\u01b0\u1ee3t kh\u00e1m y h\u1ecdc c\u1ed5 truy\u1ec1n li\u00ean quan \u0111\u1ebfn ung th\u01b0 v\u00fa trong n\u0103m 2008 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng m\u00e3 ICD-9. C\u00e1c \u0111\u01a1n thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea trong nh\u1eefng l\u1ea7n kh\u00e1m n\u00e0y \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p khai ph\u00e1 lu\u1eadt k\u1ebft h\u1ee3p (association rule mining) nh\u1eb1m \u0111\u00e1nh gi\u00e1 c\u00e1c t\u1ed5 h\u1ee3p thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c Trung Qu\u1ed1c (Chinese Herbal Medicine &#8211; CHM) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T\u1ed5ng c\u1ed9ng c\u00f3 <strong>37.176 \u0111\u01a1n thu\u1ed1c<\/strong> \u0111\u01b0\u1ee3c k\u00ea cho <strong>4.436 b\u1ec7nh nh\u00e2n ngo\u1ea1i tr\u00fa<\/strong> m\u1eafc ung th\u01b0 v\u00fa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Th\u00f4ng qua ph\u00e2n t\u00edch lu\u1eadt k\u1ebft h\u1ee3p v\u00e0 ph\u00e2n t\u00edch m\u1ea1ng l\u01b0\u1edbi, nghi\u00ean c\u1ee9u x\u00e1c \u0111\u1ecbnh r\u1eb1ng <strong>B\u1ea1ch hoa x\u00e0 thi\u1ec7t th\u1ea3o (Hedyotis diffusa) ph\u1ed1i h\u1ee3p v\u1edbi B\u00e1n chi li\u00ean (Scutellaria barbata)<\/strong> l\u00e0 c\u1eb7p thu\u1ed1c hai v\u1ecb \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn nh\u1ea5t (<strong>10,9%<\/strong>) v\u00e0 \u0111\u00f3ng vai tr\u00f2 l\u00e0 <strong>li\u1ec7u ph\u00e1p c\u1ed1t l\u00f5i<\/strong> trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Gia V\u1ecb Ti\u00eau Dao T\u00e1n (Jia-Wei-Xiao-Yao-San)<\/strong> l\u00e0 b\u00e0i thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n nhi\u1ec1u nh\u1ea5t (<strong>19,6%<\/strong>), trong khi <strong>B\u1ea1ch hoa x\u00e0 thi\u1ec7t th\u1ea3o (Hedyotis diffusa)<\/strong> l\u00e0 v\u1ecb thu\u1ed1c \u0111\u01a1n \u0111\u01b0\u1ee3c k\u00ea nhi\u1ec1u nh\u1ea5t (<strong>41,9%<\/strong>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ch\u1ec9 c\u00f3 kho\u1ea3ng <strong>35% c\u00e1c thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c Trung Qu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn<\/strong> \u0111\u00e3 t\u1eebng \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u1ec1 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb. Do \u0111\u00f3, c\u1ea7n c\u00f3 th\u00eam nhi\u1ec1u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a c\u00e1c thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c Trung Qu\u1ed1c n\u00e0y trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n I v\u00e0 t\u00e1c d\u1ee5ng ch\u1ed1ng kh\u1ed1i u c\u1ee7a BZL101 \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa giai \u0111o\u1ea1n ti\u1ebfn tri\u1ec3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17111207<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c li\u1ec7u ph\u00e1p c\u00f3 ngu\u1ed3n g\u1ed1c th\u1ef1c v\u1eadt th\u01b0\u1eddng \u0111\u01b0\u1ee3c b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa s\u1eed d\u1ee5ng, tuy nhi\u00ean r\u1ea5t \u00edt th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a ch\u00fang. Ch\u00fang t\u00f4i \u0111\u00e3 nghi\u00ean c\u1ee9u c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng v\u00e0 ti\u1ebfn h\u00e0nh m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha I tr\u00ean b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa giai \u0111o\u1ea1n ti\u1ebfn tri\u1ec3n nh\u1eb1m \u0111\u00e1nh gi\u00e1 <strong>BZL101<\/strong>, m\u1ed9t d\u1ecbch chi\u1ebft n\u01b0\u1edbc t\u1eeb Scutellaria barbata (B\u00e1n chi li\u00ean).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Ph\u01b0\u01a1ng ph\u00e1p<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong ph\u00f2ng th\u00ed nghi\u1ec7m (in vitro) nh\u1eb1m x\u00e1c \u0111\u1ecbnh \u0111\u1eb7c \u0111i\u1ec3m qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o do BZL101 g\u00e2y ra.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trong th\u1eed nghi\u1ec7m pha I, c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n ph\u1ea3i c\u00f3 ch\u1ea9n \u0111o\u00e1n x\u00e1c \u0111\u1ecbnh b\u1eb1ng m\u00f4 b\u1ec7nh h\u1ecdc v\u1ec1 ung th\u01b0 v\u00fa di c\u0103n v\u00e0 c\u00f3 t\u1ed5n th\u01b0\u01a1ng c\u00f3 th\u1ec3 \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110i\u1ec1u tr\u1ecb bao g\u1ed3m u\u1ed1ng <strong>350 ml BZL101 m\u1ed7i ng\u00e0y<\/strong>, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 <strong>li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 duy nh\u1ea5t<\/strong>, cho \u0111\u1ebfn khi b\u1ec7nh ti\u1ebfn tri\u1ec3n, xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh kh\u00f4ng ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c ho\u1eb7c b\u1ec7nh nh\u00e2n t\u1ef1 nguy\u1ec7n ng\u1eebng \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ch\u00ednh bao g\u1ed3m:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>T\u00ednh an to\u00e0n.<\/li>\n\n\n\n<li>\u0110\u1ed9c t\u00ednh.<\/li>\n\n\n\n<li>\u0110\u00e1p \u1ee9ng c\u1ee7a kh\u1ed1i u.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">K\u1ebft qu\u1ea3<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">D\u1ecbch chi\u1ebft BZL101 g\u00e2y <strong>\u1ee9c ch\u1ebf t\u0103ng tr\u01b0\u1edfng m\u1ea1nh v\u00e0 k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh ch\u1ebft theo ch\u01b0\u01a1ng tr\u00ecnh (apoptosis)<\/strong> tr\u00ean c\u00e1c d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 v\u00fa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trong th\u1eed nghi\u1ec7m pha I:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C\u00f3 <strong>21 b\u1ec7nh nh\u00e2n<\/strong> \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng BZL101.<\/li>\n\n\n\n<li>Tu\u1ed5i trung b\u00ecnh l\u00e0 <strong>54 tu\u1ed5i<\/strong> (dao \u0111\u1ed9ng t\u1eeb 30\u201377 tu\u1ed5i).<\/li>\n\n\n\n<li>S\u1ed1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3 cho b\u1ec7nh ung th\u01b0 di c\u0103n trung b\u00ecnh l\u00e0 <strong>3,9 l\u1ea7n<\/strong> (dao \u0111\u1ed9ng t\u1eeb 0\u201310 l\u1ea7n).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Kh\u00f4ng ghi nh\u1eadn b\u1ea5t k\u1ef3 t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i (AE) \u0111\u1ed9 III ho\u1eb7c IV n\u00e0o.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i \u0111\u1ed9 I v\u00e0 II li\u00ean quan \u0111\u1ebfn BZL101 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o nhi\u1ec1u nh\u1ea5t g\u1ed3m:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Bu\u1ed3n n\u00f4n: 38%<\/li>\n\n\n\n<li>Ti\u00eau ch\u1ea3y: 24%<\/li>\n\n\n\n<li>\u0110au \u0111\u1ea7u: 19%<\/li>\n\n\n\n<li>\u0110\u1ea7y h\u01a1i: 14%<\/li>\n\n\n\n<li>N\u00f4n: 10%<\/li>\n\n\n\n<li>T\u00e1o b\u00f3n: 10%<\/li>\n\n\n\n<li>M\u1ec7t m\u1ecfi: 10%<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00f3 <strong>16 b\u1ec7nh nh\u00e2n<\/strong> \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n \u0111\u00e1nh gi\u00e1 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trong s\u1ed1 n\u00e0y:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>4 b\u1ec7nh nh\u00e2n c\u00f3 b\u1ec7nh \u1ed5n \u0111\u1ecbnh (Stable Disease &#8211; SD) k\u00e9o d\u00e0i tr\u00ean 90 ng\u00e0y (25%).<\/li>\n\n\n\n<li>3\/16 b\u1ec7nh nh\u00e2n c\u00f3 b\u1ec7nh \u1ed5n \u0111\u1ecbnh k\u00e9o d\u00e0i tr\u00ean 180 ng\u00e0y (19%).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00f3 <strong>5 b\u1ec7nh nh\u00e2n ghi nh\u1eadn s\u1ef1 tho\u00e1i lui kh\u00e1ch quan c\u1ee7a kh\u1ed1i u (objective tumor regression)<\/strong>, trong \u0111\u00f3 c\u00f3 <strong>1 b\u1ec7nh nh\u00e2n ch\u1ec9 thi\u1ebfu 1 mm \u0111\u1ec3 \u0111\u1ea1t ti\u00eau chu\u1ea9n \u0111\u00e1p \u1ee9ng m\u1ed9t ph\u1ea7n (Partial Response &#8211; PR)<\/strong> theo ti\u00eau chu\u1ea9n RECIST.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">K\u1ebft lu\u1eadn<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">BZL101 \u1ee9c ch\u1ebf c\u00e1c d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 v\u00fa th\u00f4ng qua vi\u1ec7c k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh ch\u1ebft theo ch\u01b0\u01a1ng tr\u00ecnh c\u1ee7a t\u1ebf b\u00e0o.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha I, BZL101 cho th\u1ea5y:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0110\u1ed9 an to\u00e0n t\u1ed1t.<\/li>\n\n\n\n<li>H\u1ed3 s\u01a1 \u0111\u1ed9c t\u00ednh thu\u1eadn l\u1ee3i.<\/li>\n\n\n\n<li>Kh\u1ea3 n\u0103ng dung n\u1ea1p cao.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">BZL101 c\u0169ng th\u1ec3 hi\u1ec7n <strong>ho\u1ea1t t\u00ednh l\u00e2m s\u00e0ng \u0111\u1ea7y h\u1ee9a h\u1eb9n<\/strong> \u1edf nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u00e3 tr\u1ea3i qua nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3 nh\u01b0ng b\u1ec7nh v\u1eabn ti\u1ebfn tri\u1ec3n.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0110i\u1ec3m \u0111\u00e1ng ch\u00fa \u00fd c\u1ee7a nghi\u00ean c\u1ee9u<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110\u00e2y l\u00e0 m\u1ed9t trong s\u1ed1 r\u1ea5t \u00edt nghi\u00ean c\u1ee9u m\u00e0 <strong>d\u1ecbch chi\u1ebft B\u00e1n chi li\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u01a1n \u0111\u1ed9c tr\u00ean ng\u01b0\u1eddi b\u1ec7nh ung th\u01b0 v\u00fa di c\u0103n<\/strong>, thay v\u00ec ch\u1ec9 d\u1eebng \u1edf nghi\u00ean c\u1ee9u t\u1ebf b\u00e0o ho\u1eb7c \u0111\u1ed9ng v\u1eadt. M\u1eb7c d\u00f9 ch\u01b0a c\u00f3 b\u1ec7nh nh\u00e2n n\u00e0o \u0111\u1ea1t \u0111\u00e1p \u1ee9ng ho\u00e0n to\u00e0n (CR) ho\u1eb7c \u0111\u00e1p \u1ee9ng m\u1ed9t ph\u1ea7n ch\u00ednh th\u1ee9c (PR), nh\u01b0ng vi\u1ec7c c\u00f3 <strong>5\/16 b\u1ec7nh nh\u00e2n xu\u1ea5t hi\u1ec7n thu nh\u1ecf kh\u1ed1i u<\/strong> v\u00e0 <strong>19% duy tr\u00ec b\u1ec7nh \u1ed5n \u0111\u1ecbnh tr\u00ean 6 th\u00e1ng<\/strong> l\u00e0 t\u00edn hi\u1ec7u \u0111\u00e1ng ch\u00fa \u00fd \u0111\u1ed1i v\u1edbi m\u1ed9t th\u1eed nghi\u1ec7m pha I v\u1ed1n ch\u1ee7 y\u1ebfu nh\u1eb1m \u0111\u00e1nh gi\u00e1 \u0111\u1ed9 an to\u00e0n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pha II<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">https:\/\/pubmed.ncbi.nlm.nih.gov\/20054647<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha 1B t\u0103ng d\u1ea7n li\u1ec1u d\u00f9ng c\u1ee7a B\u00e1n chi li\u00ean (Scutellaria barbata, BZL101) tr\u00ean b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa di c\u0103n<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M\u1ee5c \u0111\u00edch c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y l\u00e0 x\u00e1c \u0111\u1ecbnh <strong>\u0111\u1ed9 an to\u00e0n<\/strong> v\u00e0 <strong>li\u1ec1u dung n\u1ea1p t\u1ed1i \u0111a (Maximum Tolerated Dose &#8211; MTD)<\/strong> c\u1ee7a <strong>BZL101 (FDA IND# 59,521)<\/strong>, m\u1ed9t d\u1ecbch chi\u1ebft n\u01b0\u1edbc d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng t\u1eeb d\u01b0\u1ee3c li\u1ec7u Scutellaria barbata, tr\u00ean ph\u1ee5 n\u1eef m\u1eafc <strong>ung th\u01b0 v\u00fa di c\u0103n (Metastatic Breast Cancer &#8211; MBC)<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf d\u01b0\u1edbi d\u1ea1ng <strong>th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha 1B, \u0111a trung t\u00e2m, nh\u00e3n m\u1edf (open-label), t\u0103ng d\u1ea7n li\u1ec1u d\u00f9ng (dose-escalation study)<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c b\u1ec7nh nh\u00e2n \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n tham gia ph\u1ea3i c\u00f3:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ch\u1ea9n \u0111o\u00e1n ung th\u01b0 v\u00fa \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn b\u1eb1ng m\u00f4 b\u1ec7nh h\u1ecdc.<\/li>\n\n\n\n<li>B\u1ec7nh giai \u0111o\u1ea1n IV c\u00f3 t\u1ed5n th\u01b0\u01a1ng \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Thi\u1ebft k\u1ebf pha I ti\u00eau chu\u1ea9n <strong>&#8220;3 + 3&#8221;<\/strong> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh MTD.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ch\u00ednh bao g\u1ed3m:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0110\u1ed9c t\u00ednh.<\/li>\n\n\n\n<li>Li\u1ec1u dung n\u1ea1p t\u1ed1i \u0111a (MTD) c\u1ee7a BZL101.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ph\u1ee5 bao g\u1ed3m:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb d\u1ef1a tr\u00ean ti\u00eau chu\u1ea9n <strong>RECIST<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">T\u1ed5ng c\u1ed9ng c\u00f3 <strong>27 ph\u1ee5 n\u1eef<\/strong> tham gia nghi\u00ean c\u1ee9u. S\u1ed1 l\u1ea7n \u0111i\u1ec1u tr\u1ecb h\u00f3a ch\u1ea5t tr\u01b0\u1edbc \u0111\u00f3 cho b\u1ec7nh di c\u0103n trung v\u1ecb l\u00e0 <strong>2 ph\u00e1c \u0111\u1ed3<\/strong>. C\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed5 v\u00e0o <strong>4 nh\u00f3m li\u1ec1u kh\u00e1c nhau<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i (Adverse Events &#8211; AEs) \u0111\u1ed9 3 v\u00e0 \u0111\u1ed9 4 t\u01b0\u01a1ng \u0111\u1ed1i hi\u1ebfm g\u1eb7p.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c \u0111\u1ed9c t\u00ednh gi\u1edbi h\u1ea1n li\u1ec1u (Dose-Limiting Toxicities &#8211; DLTs) bao g\u1ed3m:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>T\u0103ng AST \u0111\u1ed9 4.<\/li>\n\n\n\n<li>Ti\u00eau ch\u1ea3y \u0111\u1ed9 3.<\/li>\n\n\n\n<li>M\u1ec7t m\u1ecfi \u0111\u1ed9 3.<\/li>\n\n\n\n<li>\u0110au x\u01b0\u01a1ng s\u01b0\u1eddn \u0111\u1ed9 3.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00f3 <strong>14 b\u1ec7nh nh\u00e2n<\/strong> \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb theo ti\u00eau chu\u1ea9n <strong>Response Evaluation Criteria in Solid Tumors (RECIST)<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Theo \u0111\u00e1nh gi\u00e1 c\u1ee7a c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C\u00f3 <strong>3 b\u1ec7nh nh\u00e2n duy tr\u00ec b\u1ec7nh \u1ed5n \u0111\u1ecbnh (Stable Disease &#8211; SD) tr\u00ean 120 ng\u00e0y<\/strong>, chi\u1ebfm <strong>21%<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110\u1eb7c bi\u1ec7t:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C\u00f3 <strong>1 b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng BZL101 trong 449 ng\u00e0y<\/strong> v\u00e0 v\u1eabn duy tr\u00ec t\u00ecnh tr\u1ea1ng b\u1ec7nh \u1ed5n \u0111\u1ecbnh tr\u00ean <strong>700 ng\u00e0y<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Khi \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 \u0111\u1ed9c l\u1eadp b\u1eb1ng h\u00ecnh \u1ea3nh h\u1ecdc:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C\u00f3 <strong>3 b\u1ec7nh nh\u00e2n xu\u1ea5t hi\u1ec7n hi\u1ec7n t\u01b0\u1ee3ng thu nh\u1ecf kh\u1ed1i u kh\u00e1ch quan (objective tumor regression)<\/strong> v\u1edbi m\u1ee9c gi\u1ea3m k\u00edch th\u01b0\u1edbc kh\u1ed1i u <strong>l\u1edbn h\u01a1n 0% nh\u01b0ng d\u01b0\u1edbi 30%<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Li\u1ec1u dung n\u1ea1p t\u1ed1i \u0111a (MTD) <strong>kh\u00f4ng \u0111\u1ea1t t\u1edbi trong nghi\u00ean c\u1ee9u<\/strong>. Do \u0111\u00f3, theo quy \u0111\u1ecbnh c\u1ee7a \u0111\u1ec1 c\u01b0\u01a1ng nghi\u00ean c\u1ee9u, MTD \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 <strong>li\u1ec1u cao nh\u1ea5t \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng<\/strong>, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng <strong>40 g BZL101 m\u1ed7i ng\u00e0y<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">K\u1ebft lu\u1eadn<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Vi\u1ec7c s\u1eed d\u1ee5ng BZL101 \u0111\u01b0\u1eddng u\u1ed1ng cho th\u1ea5y:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>An to\u00e0n.<\/li>\n\n\n\n<li>\u0110\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t.<\/li>\n\n\n\n<li>C\u00f3 h\u1ed3 s\u01a1 \u0111\u1ed9c t\u00ednh thu\u1eadn l\u1ee3i.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Ngo\u00e0i ra, BZL101 c\u00f2n cho th\u1ea5y nh\u1eefng b\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng \u0111\u1ea7y h\u1ee9a h\u1eb9n v\u1ec1 ho\u1ea1t t\u00ednh ch\u1ed1ng ung th\u01b0 \u1edf nh\u00f3m ph\u1ee5 n\u1eef m\u1eafc ung th\u01b0 v\u00fa di c\u0103n \u0111\u00e3 tr\u1ea3i qua nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ti\u00eau chu\u1ea9n l\u1ef1a ch\u1ecdn b\u1ec7nh nh\u00e2n (Inclusion Criteria)<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ph\u1ee5 n\u1eef t\u1eeb <strong>18 tu\u1ed5i tr\u1edf l\u00ean<\/strong>.<\/li>\n\n\n\n<li>Ch\u1ea9n \u0111o\u00e1n ung th\u01b0 v\u00fa \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn b\u1eb1ng m\u00f4 b\u1ec7nh h\u1ecdc d\u1ef1a tr\u00ean k\u1ebft qu\u1ea3 gi\u1ea3i ph\u1eabu b\u1ec7nh c\u1ee7a kh\u1ed1i u nguy\u00ean ph\u00e1t, t\u1ed5n th\u01b0\u01a1ng v\u00f9ng ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng di c\u0103n.<\/li>\n\n\n\n<li>C\u00f3 b\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng v\u1ec1 <strong>ung th\u01b0 v\u00fa di c\u0103n (giai \u0111o\u1ea1n IV)<\/strong> ngo\u00e0i tr\u01b0\u1eddng h\u1ee3p ch\u1ec9 di c\u0103n x\u01b0\u01a1ng, d\u1ef1a tr\u00ean \u0111\u00e1nh gi\u00e1 l\u00e2m s\u00e0ng v\u00e0\/ho\u1eb7c h\u00ecnh \u1ea3nh h\u1ecdc c\u1ee7a nh\u00e0 nghi\u00ean c\u1ee9u.<\/li>\n\n\n\n<li>C\u00f3 s\u1eb5n k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m t\u00ecnh tr\u1ea1ng <strong>th\u1ee5 th\u1ec3 estrogen (ER)<\/strong> v\u00e0 <strong>th\u1ee5 th\u1ec3 progesterone (PR)<\/strong> tr\u00ean m\u1eabu sinh thi\u1ebft. (K\u1ebft qu\u1ea3 ER\/PR c\u1ee7a l\u1ea7n sinh thi\u1ebft g\u1ea7n nh\u1ea5t c\u00f3 ghi nh\u1eadn c\u00e1c ch\u1ec9 s\u1ed1 n\u00e0y s\u1ebd \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ph\u00e2n t\u1ea7ng b\u1ec7nh nh\u00e2n theo t\u00ecnh tr\u1ea1ng th\u1ee5 th\u1ec3 n\u1ed9i ti\u1ebft.)<\/li>\n\n\n\n<li>C\u00f3 \u00edt nh\u1ea5t <strong>m\u1ed9t t\u1ed5n th\u01b0\u01a1ng \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c<\/strong> theo ti\u00eau chu\u1ea9n RECIST, \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong v\u00f2ng 30 ng\u00e0y tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb nghi\u00ean c\u1ee9u. C\u00e1c t\u1ed5n th\u01b0\u01a1ng <strong>kh\u00f4ng \u0111\u01b0\u1ee3c xem l\u00e0 \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c<\/strong> bao g\u1ed3m:<ul><li>T\u1ed5n th\u01b0\u01a1ng x\u01b0\u01a1ng.<\/li><li>Di c\u0103n m\u00e0ng n\u00e3o m\u1ec1m (leptomeningeal disease).<\/li><li>C\u1ed5 tr\u01b0\u1edbng.<\/li><li>Tr\u00e0n d\u1ecbch m\u00e0ng ph\u1ed5i ho\u1eb7c m\u00e0ng tim.<\/li><li>Ung th\u01b0 v\u00fa th\u1ec3 vi\u00eam.<\/li><li>Vi\u00eam b\u1ea1ch m\u1ea1ch da ho\u1eb7c ph\u1ed5i do ung th\u01b0.<\/li><li>Kh\u1ed1i u trong \u1ed5 b\u1ee5ng ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn v\u00e0 theo d\u00f5i b\u1eb1ng ph\u01b0\u01a1ng ti\u1ec7n ch\u1ea9n \u0111o\u00e1n h\u00ecnh \u1ea3nh.<\/li><li>T\u1ed5n th\u01b0\u01a1ng d\u1ea1ng nang.<\/li><\/ul>\u0110\u1ed1i v\u1edbi c\u00e1c t\u1ed5n th\u01b0\u01a1ng n\u1eb1m trong v\u00f9ng \u0111\u00e3 t\u1eebng x\u1ea1 tr\u1ecb, t\u1ed5n th\u01b0\u01a1ng \u0111\u00f3 ch\u1ec9 \u0111\u01b0\u1ee3c xem l\u00e0 t\u1ed5n th\u01b0\u01a1ng \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c n\u1ebfu \u0111\u00e3 c\u00f3 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y n\u00f3 ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n sau x\u1ea1 tr\u1ecb.<\/li>\n\n\n\n<li>\u0110\u00e3 \u0111i\u1ec1u tr\u1ecb kh\u00f4ng qu\u00e1 <strong>2 ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb \u0111\u1ed9c t\u1ebf b\u00e0o<\/strong> cho ung th\u01b0 v\u00fa di c\u0103n. (B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 \u0111\u00e3 s\u1eed d\u1ee5ng b\u1ea5t k\u1ef3 s\u1ed1 l\u01b0\u1ee3ng li\u1ec7u ph\u00e1p n\u1ed9i ti\u1ebft n\u00e0o cho b\u1ec7nh giai \u0111o\u1ea1n IV v\u00e0\/ho\u1eb7c \u0111i\u1ec1u tr\u1ecb b\u1ed5 tr\u1ee3 tr\u01b0\u1edbc \u0111\u00f3.)<\/li>\n\n\n\n<li>Th\u1eddi gian s\u1ed1ng d\u1ef1 ki\u1ebfn tr\u00ean <strong>12 tu\u1ea7n<\/strong>.<\/li>\n\n\n\n<li>Ch\u1ec9 s\u1ed1 ho\u1ea1t \u0111\u1ed9ng th\u1ec3 tr\u1ea1ng theo thang \u0111i\u1ec3m <strong>ECOG (Eastern Cooperative Oncology Group) &lt; 2<\/strong>.<\/li>\n\n\n\n<li>Ph\u1ee5 n\u1eef c\u00f2n kh\u1ea3 n\u0103ng sinh s\u1ea3n ph\u1ea3i \u0111\u1ed3ng \u00fd s\u1eed d\u1ee5ng <strong>hai bi\u1ec7n ph\u00e1p tr\u00e1nh thai th\u00edch h\u1ee3p<\/strong> ho\u1eb7c ki\u00eang quan h\u1ec7 t\u00ecnh d\u1ee5c trong su\u1ed1t th\u1eddi gian tham gia nghi\u00ean c\u1ee9u. C\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn g\u1ed3m:\n<ul class=\"wp-block-list\">\n<li>D\u1ee5ng c\u1ee5 t\u1eed cung (IUD).<\/li>\n\n\n\n<li>Thu\u1ed1c tr\u00e1nh thai n\u1ed9i ti\u1ebft.<\/li>\n\n\n\n<li>Th\u1eaft \u1ed1ng d\u1eabn tr\u1ee9ng.<\/li>\n\n\n\n<li>B\u1ea1n t\u00ecnh \u0111\u00e3 th\u1eaft \u1ed1ng d\u1eabn tinh.<\/li>\n\n\n\n<li>Bao cao su latex.<\/li>\n\n\n\n<li>M\u00e0ng ng\u0103n \u00e2m \u0111\u1ea1o (diaphragm).<\/li>\n\n\n\n<li>N\u1eafp c\u1ed5 t\u1eed cung (cervical cap).<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Ch\u1ee9c n\u0103ng t\u1ea1ng v\u00e0 t\u1ee7y x\u01b0\u01a1ng \u0111\u1ea7y \u0111\u1ee7, \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong v\u00f2ng 14 ng\u00e0y tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb nghi\u00ean c\u1ee9u, \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau chu\u1ea9n sau:\n<ul class=\"wp-block-list\">\n<li>S\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh tuy\u1ec7t \u0111\u1ed1i (ANC) > 1.500 t\u1ebf b\u00e0o\/mm\u00b3.<\/li>\n\n\n\n<li>Ti\u1ec3u c\u1ea7u > 100.000 t\u1ebf b\u00e0o\/mm\u00b3.<\/li>\n\n\n\n<li>Hemoglobin > 10 g\/dL.<\/li>\n\n\n\n<li>Bilirubin to\u00e0n ph\u1ea7n &lt; 1,5 mg\/dL.<\/li>\n\n\n\n<li>AST (SGOT) ho\u1eb7c ALT (SGPT) &lt; 2,5 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng c\u1ee7a c\u01a1 s\u1edf x\u00e9t nghi\u1ec7m; ho\u1eb7c &lt; 5 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng n\u1ebfu c\u00f3 b\u1eb1ng ch\u1ee9ng di c\u0103n gan.<\/li>\n\n\n\n<li>Phosphatase ki\u1ec1m (ALP) &lt; 3 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng; ho\u1eb7c &lt; 5 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng n\u1ebfu c\u00f3 b\u1eb1ng ch\u1ee9ng di c\u0103n gan ho\u1eb7c di c\u0103n x\u01b0\u01a1ng.<\/li>\n\n\n\n<li>Creatinin huy\u1ebft thanh &lt; 1,5 mg\/dL; ho\u1eb7c \u0111\u1ed9 thanh th\u1ea3i creatinin > 60 mL\/ph\u00fat\/1,73 m\u00b2 \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 creatinin huy\u1ebft thanh cao h\u01a1n gi\u1edbi h\u1ea1n b\u00ecnh th\u01b0\u1eddng c\u1ee7a c\u01a1 s\u1edf x\u00e9t nghi\u1ec7m.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">T\u00f3m t\u1eaft ng\u1eafn g\u1ecdn<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Nghi\u00ean c\u1ee9u n\u00e0y tuy\u1ec3n c\u00e1c b\u1ec7nh nh\u00e2n:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ung th\u01b0 v\u00fa giai \u0111o\u1ea1n IV \u0111\u00e3 di c\u0103n.<\/li>\n\n\n\n<li>T\u00ecnh tr\u1ea1ng to\u00e0n th\u00e2n c\u00f2n kh\u00e1 t\u1ed1t (ECOG 0\u20131).<\/li>\n\n\n\n<li>Ch\u1ee9c n\u0103ng gan, th\u1eadn, t\u1ee7y x\u01b0\u01a1ng c\u00f2n b\u1ea3o t\u1ed3n.<\/li>\n\n\n\n<li>\u0110\u00e3 \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3 nh\u01b0ng ch\u01b0a qu\u00e1 2 ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb cho b\u1ec7nh di c\u0103n.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110i\u1ec1u \u0111\u00f3 c\u00f3 ngh\u0129a \u0111\u00e2y <strong>kh\u00f4ng ph\u1ea3i l\u00e0 nh\u00f3m b\u1ec7nh nh\u00e2n giai \u0111o\u1ea1n cu\u1ed1i suy ki\u1ec7t<\/strong>, m\u00e0 l\u00e0 nh\u00f3m v\u1eabn c\u00f2n \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n tham gia th\u1eed nghi\u1ec7m thu\u1ed1c m\u1edbi, gi\u00fap \u0111\u00e1nh gi\u00e1 t\u01b0\u01a1ng \u0111\u1ed1i ch\u00ednh x\u00e1c \u0111\u1ed9 an to\u00e0n v\u00e0 t\u00edn hi\u1ec7u hi\u1ec7u qu\u1ea3 c\u1ee7a BZL101.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">https:\/\/ichgcp.net\/clinical-trials-registry\/NCT00907959<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B\u1ea1ch hoa x\u00e0 thi\u1ec7t th\u1ea3o k\u1ebft h\u1ee3p v\u1edbi B\u00e1n chi li\u00ean \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf th\u00f4ng qua c\u00e1c con \u0111\u01b0\u1eddng t\u00edn hi\u1ec7u NLRP3\/NF-\u03baB\/MAPK<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34239588<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<!-- relpost-thumb-wrapper --><div class=\"relpost-thumb-wrapper\"><!-- filter-class --><div class=\"relpost-thumb-container\"><style>.relpost-block-single-image, .relpost-post-image { margin-bottom: 10px; 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