{"id":634,"date":"2026-05-10T23:01:40","date_gmt":"2026-05-10T23:01:40","guid":{"rendered":"https:\/\/thuoc115.com\/suckhoe\/?p=634"},"modified":"2026-05-10T23:07:23","modified_gmt":"2026-05-10T23:07:23","slug":"hoat-dong-chong-oxy-hoa-va-bao-ve-mach-mau-cua-thanh-nganh","status":"publish","type":"post","link":"https:\/\/thuoc115.com\/suckhoe\/hoat-dong-chong-oxy-hoa-va-bao-ve-mach-mau-cua-thanh-nganh\/","title":{"rendered":"Ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng oxy h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 m\u1ea1ch m\u00e1u c\u1ee7a th\u00e0nh ng\u1ea1nh"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">huy\u1ebft \u0111\u1ed9ng<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C\u00e1c h\u1ee3p ch\u1ea5t th\u1ef1c v\u1eadt c\u00f3 trong c\u00e2y d\u00f9ng l\u00e0m th\u1ef1c ph\u1ea9m mang l\u1ea1i nhi\u1ec1u l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe v\u00e0 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh tim m\u1ea1ch. D\u1ecbch chi\u1ebft n\u01b0\u1edbc t\u1eeb ba lo\u1ea1i c\u00e2y th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c li\u1ec7u ph\u1ed5 bi\u1ebfn c\u1ee7a Th\u00e1i Lan l\u00e0 Cratoxylum formosum, Syzygium gratum v\u00e0 Limnophila aromatica \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u1ec1 ho\u1ea1t t\u00ednh ch\u1ed1ng oxy h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 m\u1ea1ch m\u00e1u tr\u00ean c\u00e1c m\u00f4 h\u00ecnh in vitro v\u00e0 in vivo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kh\u1ea3 n\u0103ng b\u1eaft gi\u1eef g\u1ed1c t\u1ef1 do v\u00e0 ho\u1ea1t t\u00ednh ch\u1ed1ng oxy h\u00f3a c\u1ee7a c\u00e1c d\u1ecbch chi\u1ebft th\u1ef1c v\u1eadt \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 in vitro b\u1eb1ng ph\u00e9p th\u1eed 1,1-diphenyl-2-picrylhydrazyl (DPPH), ph\u00e9p th\u1eed kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a kh\u1eed s\u1eaft (FRAP), ho\u1ea1t t\u00ednh ch\u1ed1ng oxy h\u00f3a n\u1ed9i b\u00e0o tr\u00ean \u0111\u1ea1i th\u1ef1c b\u00e0o ph\u00fac m\u1ea1c chu\u1ed9t b\u1eb1ng ph\u00e9p th\u1eed dihydrofluorescein, v\u00e0 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf s\u1ea3n xu\u1ea5t nitric oxide (NO) tr\u00ean \u0111\u1ea1i th\u1ef1c b\u00e0o RAW 264.7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Trong m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt v\u1ec1 stress oxy h\u00f3a v\u00e0 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng m\u1ea1ch m\u00e1u, chu\u1ed9t \u0111\u1ef1c Sprague-Dawley \u0111\u01b0\u1ee3c cho u\u1ed1ng d\u1ecbch chi\u1ebft n\u01b0\u1edbc c\u1ee7a c\u00e2y (1 g\/kg\/ng\u00e0y) ho\u1eb7c N-acetylcysteine (NAC; 300 mg\/kg\/ng\u00e0y) l\u00e0m \u0111\u1ed1i ch\u1ee9ng trong 6 ng\u00e0y. V\u00e0o ng\u00e0y th\u1ee9 t\u01b0, t\u1ea5t c\u1ea3 \u0111\u1ed9ng v\u1eadt ngo\u1ea1i tr\u1eeb nh\u00f3m ch\u1ee9ng b\u00ecnh th\u01b0\u1eddng \u0111\u1ec1u \u0111\u01b0\u1ee3c ti\u00eam phenylhydrazine (PHZ) v\u00e0o ph\u00fac m\u1ea1c.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">K\u1ebft qu\u1ea3 cho th\u1ea5y c\u00e1c d\u1ecbch chi\u1ebft th\u1ef1c v\u1eadt c\u00f3 ho\u1ea1t t\u00ednh b\u1eaft gi\u1eef g\u1ed1c t\u1ef1 do v\u00e0 ch\u1ed1ng oxy h\u00f3a cao. PHZ g\u00e2y tan m\u00e1u n\u1eb7ng v\u00e0 r\u1ed1i lo\u1ea1n huy\u1ebft \u0111\u1ed9ng, v\u00e0 vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c d\u1ecbch chi\u1ebft ho\u1eb7c NAC \u0111\u00e3 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 t\u00ecnh tr\u1ea1ng huy\u1ebft \u0111\u1ed9ng.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0110\u00e1p \u1ee9ng m\u1ea1ch m\u00e1u v\u1edbi bradykinin, acetylcholine v\u00e0 phenylephrine \u1edf nh\u00f3m chu\u1ed9t \u0111\u1ed1i ch\u1ee9ng PHZ b\u1ecb suy gi\u1ea3m r\u00f5 r\u1ec7t, v\u00e0 c\u00e1c d\u1ecbch chi\u1ebft th\u1ef1c v\u1eadt ho\u1eb7c NAC \u0111\u00e3 ph\u1ee5c h\u1ed3i ph\u1ea7n l\u1edbn c\u00e1c \u0111\u00e1p \u1ee9ng m\u1ea1ch m\u00e1u n\u00e0y.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">H\u01a1n n\u1eefa, c\u00e1c d\u1ecbch chi\u1ebft th\u1ef1c v\u1eadt c\u00f2n ng\u0103n ng\u1eeba s\u1ef1 suy gi\u1ea3m glutathione d\u1ea1ng kh\u1eed trong m\u00e1u v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh malondialdehyde huy\u1ebft t\u01b0\u01a1ng, c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a NO trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 anion superoxide trong m\u00e1u.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">K\u1ebft lu\u1eadn r\u1eb1ng c\u00e1c d\u1ecbch chi\u1ebft th\u1ef1c v\u1eadt n\u00e0y c\u00f3 ho\u1ea1t t\u00ednh ch\u1ed1ng oxy h\u00f3a v\u00e0 c\u00f3 ti\u1ec1m n\u0103ng trong vi\u1ec7c b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng m\u1ea1ch m\u00e1u.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17409498<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">https:\/\/www.jstage.jst.go.jp\/article\/bpb\/30\/4\/30_4_661\/_pdf\/-char\/en<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Chi\u1ebft xu\u1ea5t Cratoxylum formosum th\u1ec3 hi\u1ec7n t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p th\u00f4ng qua \u1ee9c ch\u1ebf chu\u1ed7i ph\u1ea3n \u1ee9ng renin-angiotensin \u1edf chu\u1ed9t t\u0103ng huy\u1ebft \u00e1p<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T\u00e1c d\u1ee5ng c\u1ee7a d\u1ecbch chi\u1ebft Cratoxylum formosum (CF) l\u00ean huy\u1ebft \u00e1p c\u0169ng nh\u01b0 nh\u1eefng thay \u0111\u1ed5i v\u1ec1 c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng m\u1ea1ch m\u00e1u \u1edf chu\u1ed9t t\u0103ng huy\u1ebft \u00e1p \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u. Chu\u1ed9t \u0111\u01b0\u1ee3c d\u00f9ng L-NAME li\u1ec1u 40 mg\/kg v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng d\u1ecbch chi\u1ebft CF ho\u1eb7c captopril ho\u1eb7c ph\u1ed1i h\u1ee3p captopril + CF extract (n = 8).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">D\u1ecbch chi\u1ebft CF l\u00e0m gi\u1ea3m t\u00ecnh tr\u1ea1ng t\u0103ng huy\u1ebft \u00e1p, gi\u1ea3m s\u1ef1 t\u0103ng \u0111\u00e1p \u1ee9ng co m\u1ea1ch qua trung gian th\u1ea7n kinh, c\u1ea3i thi\u1ec7n r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u1ed9i m\u00f4 v\u00e0 c\u00e1c d\u1ea5u \u1ea5n stress oxy h\u00f3a, \u0111\u1ed3ng th\u1eddi l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a nitric oxide (NOx) \u1edf chu\u1ed9t d\u00f9ng L-NAME.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T\u00ecnh tr\u1ea1ng ph\u00ec \u0111\u1ea1i \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 \u0111i k\u00e8m v\u1edbi s\u1ef1 gia t\u0103ng ho\u1ea1t t\u00ednh ACE huy\u1ebft thanh, t\u0103ng n\u1ed3ng \u0111\u1ed9 angiotensin II trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 t\u0103ng bi\u1ec3u hi\u1ec7n protein AT1R\/Akt\/STAT3 \u1edf chu\u1ed9t t\u0103ng huy\u1ebft \u00e1p \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n b\u1edfi d\u1ecbch chi\u1ebft CF.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u1ede chu\u1ed9t t\u0103ng huy\u1ebft \u00e1p, vi\u1ec7c ph\u1ed1i h\u1ee3p captopril + CF extract cho hi\u1ec7u qu\u1ea3 m\u1ea1nh h\u01a1n trong vi\u1ec7c gi\u1ea3m huy\u1ebft \u00e1p v\u00e0 ph\u00ec \u0111\u1ea1i m\u1ea1ch m\u00e1u.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">D\u1eef li\u1ec7u c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y cho th\u1ea5y t\u00e1c d\u1ee5ng ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p c\u1ee7a d\u1ecbch chi\u1ebft CF c\u00f3 li\u00ean quan \u0111\u1ebfn:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a gi\u00fap t\u0103ng sinh kh\u1ea3 d\u1ee5ng c\u1ee7a NO,<\/li>\n\n\n\n<li>v\u00e0 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf chu\u1ed7i h\u1ec7 renin-angiotensin (RAS).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17409498<\/p>\n<!-- relpost-thumb-wrapper --><div class=\"relpost-thumb-wrapper\"><!-- filter-class --><div class=\"relpost-thumb-container\"><style>.relpost-block-single-image, .relpost-post-image { margin-bottom: 10px; 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width: 150px; height: 150px; aspect-ratio: 1\/1;\"><\/div><div class=\"relpost-block-single-text\"  style=\"height: 75px;font-family: Arial;  font-size: 12px;  color: #333333;\"><h2 class=\"relpost_card_title\">Nh\u1eefng v\u1ecb thu\u1ed1c nam ch\u1eefa b\u1ec7nh c\u01a1 b\u1ea3n<\/h2><\/div><\/div><\/a><a href=\"https:\/\/thuoc115.com\/suckhoe\/chung-tam-dom-khi-hu-nguyen-nhan-gay-ra-mat-ngu\/\"class=\"relpost-block-single\" ><div class=\"relpost-custom-block-single\"><div class=\"relpost-block-single-image rpt-lazyload\" aria-hidden=\"true\" role=\"img\" data-bg=\"https:\/\/thuoc115.com\/suckhoe\/wp-content\/plugins\/related-posts-thumbnails\/img\/default.png\" style=\"background: transparent no-repeat scroll 0% 0%; width: 150px; height: 150px; aspect-ratio: 1\/1;\"><\/div><div class=\"relpost-block-single-text\"  style=\"height: 75px;font-family: Arial;  font-size: 12px;  color: #333333;\"><h2 class=\"relpost_card_title\">Ch\u1ee9ng t\u00e2m \u0111\u1edfm kh\u00ed h\u01b0 nguy\u00ean nh\u00e2n g\u00e2y ra m\u1ea5t ng\u1ee7<\/h2><\/div><\/div><\/a><\/div><!-- close relpost-block-container --><div style=\"clear: both\"><\/div><\/div><!-- close filter class --><\/div><!-- close relpost-thumb-wrapper -->","protected":false},"excerpt":{"rendered":"<p>huy\u1ebft \u0111\u1ed9ng C\u00e1c h\u1ee3p ch\u1ea5t th\u1ef1c v\u1eadt c\u00f3 trong c\u00e2y d\u00f9ng l\u00e0m th\u1ef1c ph\u1ea9m mang l\u1ea1i nhi\u1ec1u l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe v\u00e0 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh tim m\u1ea1ch. D\u1ecbch chi\u1ebft n\u01b0\u1edbc t\u1eeb ba lo\u1ea1i c\u00e2y th\u1ef1c ph\u1ea9m v\u00e0 d\u01b0\u1ee3c li\u1ec7u ph\u1ed5 bi\u1ebfn c\u1ee7a Th\u00e1i Lan l\u00e0 Cratoxylum formosum, Syzygium gratum v\u00e0 &#8230; <a title=\"Ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng oxy h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 m\u1ea1ch m\u00e1u c\u1ee7a th\u00e0nh ng\u1ea1nh\" class=\"read-more\" href=\"https:\/\/thuoc115.com\/suckhoe\/hoat-dong-chong-oxy-hoa-va-bao-ve-mach-mau-cua-thanh-nganh\/\" aria-label=\"\u0110\u1ecdc th\u00eam v\u1ec1 Ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng oxy h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 m\u1ea1ch m\u00e1u c\u1ee7a th\u00e0nh ng\u1ea1nh\">\u0110\u1ecdc ti\u1ebfp<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-634","post","type-post","status-publish","format-standard","hentry","category-duoc-lieu"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng oxy h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 m\u1ea1ch m\u00e1u c\u1ee7a th\u00e0nh ng\u1ea1nh - Th\u00f4ng tin s\u1ee9c kh\u1ecfe<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/thuoc115.com\/suckhoe\/hoat-dong-chong-oxy-hoa-va-bao-ve-mach-mau-cua-thanh-nganh\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng oxy h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 m\u1ea1ch m\u00e1u c\u1ee7a th\u00e0nh ng\u1ea1nh - Th\u00f4ng tin s\u1ee9c kh\u1ecfe\" \/>\n<meta property=\"og:description\" content=\"huy\u1ebft \u0111\u1ed9ng C\u00e1c h\u1ee3p ch\u1ea5t th\u1ef1c v\u1eadt c\u00f3 trong c\u00e2y d\u00f9ng l\u00e0m th\u1ef1c ph\u1ea9m mang l\u1ea1i nhi\u1ec1u l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe v\u00e0 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh tim m\u1ea1ch. 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