Nghi\u00ean c\u1ee9u m\u1edbi v\u1ec1 th\u1ea3o d\u01b0\u1ee3c cho Ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf (NSCLC)<\/p>\n\n\n\n
Nano-liposome th\u1ea3o d\u01b0\u1ee3c d\u1ea1ng h\u00edt \u0111\u1ed3ng v\u1eadn chuy\u1ec3n Astragaloside IV (Ho\u00e0ng K\u1ef3) v\u00e0 Polyphyllin VII (th\u1ea5t di\u1ec7p nh\u1ea5t chi hoa) gi\u00fap t\u00e1i l\u1eadp tr\u00ecnh vi m\u00f4i tr\u01b0\u1eddng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch nh\u1eb1m v\u01b0\u1ee3t qua t\u00ecnh tr\u1ea1ng kh\u00e1ng li\u1ec7u ph\u00e1p kh\u00e1ng PD-1 trong ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf (NSCLC).<\/p>\n\n\n\n
Ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf (NSCLC) th\u01b0\u1eddng ph\u00e1t tri\u1ec3n t\u00ecnh tr\u1ea1ng kh\u00e1ng m\u1eafc ph\u1ea3i \u0111\u1ed1i v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf \u0111i\u1ec3m ki\u1ec3m so\u00e1t mi\u1ec5n d\u1ecbch (ICIs), do \u0111\u00f3 c\u1ea7n c\u00e1c chi\u1ebfn l\u01b0\u1ee3c m\u1edbi nh\u1eb1m t\u00e1i c\u1ea5u tr\u00fac vi m\u00f4i tr\u01b0\u1eddng kh\u1ed1i u mang t\u00ednh \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch (TME). Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 thi\u1ebft k\u1ebf m\u1ed9t h\u1ec7 nano-liposome d\u1ea1ng h\u00edt \u0111\u00e1p \u1ee9ng pH, \u0111\u1ed3ng v\u1eadn chuy\u1ec3n Astragaloside IV (AS-IV) v\u00e0 Polyphyllin VII (Pol VII) (AS-IV\/Pol VII-Lipo), nh\u1eb1m v\u01b0\u1ee3t qua t\u00ecnh tr\u1ea1ng kh\u00e1ng li\u1ec7u ph\u00e1p kh\u00e1ng PD-1 th\u00f4ng qua c\u01a1 ch\u1ebf ph\u00e2n ph\u1ed1i k\u00e9p hai d\u01b0\u1ee3c ch\u1ea5t c\u00f3 ki\u1ec3m so\u00e1t theo kh\u00f4ng gian v\u00e0 th\u1eddi gian.<\/p>\n\n\n\n
AS-IV\/Pol VII-Lipo (t\u1ef7 l\u1ec7 kh\u1ed1i l\u01b0\u1ee3ng 1:1) cho th\u1ea5y c\u00e1c \u0111\u1eb7c t\u00ednh l\u00fd h\u00f3a t\u1ed1i \u01b0u: t\u1ea3i l\u01b0\u1ee3ng thu\u1ed1c cao v\u00e0 kh\u1ea3 n\u0103ng gi\u1ea3i ph\u00f3ng ph\u1ee5 thu\u1ed9c pH. D\u1ea1ng h\u00edt kh\u00ed dung gi\u00fap t\u0103ng t\u00edch l\u0169y t\u1ea1i ph\u1ed5i cao g\u1ea5p 3,4 l\u1ea7n so v\u1edbi \u0111\u01b0\u1eddng u\u1ed1ng. H\u1ec7 n\u00e0y \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u ph\u1ed5i nguy\u00ean v\u1ecb LLC-Luc t\u1edbi 54%, \u0111\u1ed3ng th\u1eddi l\u00e0m gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o T CD8\u207a ki\u1ec7t s\u1ee9c v\u00e0 t\u0103ng s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o T CD8\u207aGranzyme B\u207a c\u00f3 \u0111\u1ed9c t\u00ednh t\u1ebf b\u00e0o.<\/p>\n\n\n\n
Li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p ti\u1ebfp t\u1ee5c \u1ee9c ch\u1ebf di c\u0103n kh\u1ed1i u v\u00e0 c\u1ea3i thi\u1ec7n t\u1ef7 l\u1ec7 s\u1ed1ng. Ph\u00e2n t\u00edch phi\u00ean m\u00e3 (RNA-seq) cho th\u1ea5y s\u1ef1 \u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng IL-2\/STAT5\/BLIMP1 v\u00e0 c\u00e1c gen li\u00ean quan \u0111\u1ebfn ki\u1ec7t s\u1ee9c c\u1ee7a t\u1ebf b\u00e0o T. AS-IV\/Pol VII-Lipo t\u00e1i l\u1eadp tr\u00ecnh vi m\u00f4i tr\u01b0\u1eddng kh\u1ed1i u \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch th\u00f4ng qua ba c\u01a1 ch\u1ebf hi\u1ec7p \u0111\u1ed3ng:<\/p>\n\n\n\n
(1) t\u0103ng c\u01b0\u1eddng ph\u00e2n ph\u1ed1i thu\u1ed1c \u0111\u00edch \u0111\u1ebfn ph\u1ed5i th\u00f4ng qua \u0111\u01b0\u1eddng h\u00edt;<\/p>\n\n\n\n
(2) \u0111\u1ea3o ng\u01b0\u1ee3c t\u00ecnh tr\u1ea1ng ki\u1ec7t s\u1ee9c c\u1ee7a t\u1ebf b\u00e0o T b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf tr\u1ee5c IL-2\/STAT5\/BLIMP1;<\/p>\n\n\n\n
(3) hi\u1ec7p \u0111\u1ed3ng v\u1edbi li\u1ec7u ph\u00e1p kh\u00e1ng PD-1 \u0111\u1ec3 v\u01b0\u1ee3t qua t\u00ecnh tr\u1ea1ng kh\u00e1ng ICIs.<\/p>\n\n\n\n
N\u1ec1n t\u1ea3ng nano d\u1ea1ng h\u00edt n\u00e0y m\u1edf ra m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c l\u00e2m s\u00e0ng \u0111\u1ea7y tri\u1ec3n v\u1ecdng cho b\u1ec7nh nh\u00e2n NSCLC b\u1ecb kh\u00e1ng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch m\u1eafc ph\u1ea3i.<\/p>\n\n\n\n
https:\/\/link.springer.com\/article\/10.1186\/s12575-025-00302-4<\/p>\n