{"id":543,"date":"2026-03-28T12:31:28","date_gmt":"2026-03-28T12:31:28","guid":{"rendered":"https:\/\/thuoc115.com\/suckhoe\/?p=543"},"modified":"2026-03-28T12:31:29","modified_gmt":"2026-03-28T12:31:29","slug":"lam-sang-to-co-che-dieu-tri-cua-cay-rau-meo-orthosiphon-aristatus-trong-benh-than-do-tang-acid-uric","status":"publish","type":"post","link":"https:\/\/thuoc115.com\/suckhoe\/lam-sang-to-co-che-dieu-tri-cua-cay-rau-meo-orthosiphon-aristatus-trong-benh-than-do-tang-acid-uric\/","title":{"rendered":"L\u00e0m s\u00e1ng t\u1ecf c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb c\u1ee7a c\u00e2y r\u00e2u m\u00e8o (Orthosiphon aristatus) trong b\u1ec7nh th\u1eadn do t\u0103ng acid uric"},"content":{"rendered":"\n<p>\u00dd ngh\u0129a d\u01b0\u1ee3c h\u1ecdc d\u00e2n t\u1ed9c (Ethnopharmacological relevance)<\/p>\n\n\n\n<p>B\u1ec7nh th\u1eadn do t\u0103ng acid uric (HN) v\u1eabn l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c trong \u0111i\u1ec1u tr\u1ecb do nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a c\u00e1c thu\u1ed1c hi\u1ec7n nay, bao g\u1ed3m hi\u1ec7u qu\u1ea3 kh\u00f4ng \u1ed5n \u0111\u1ecbnh v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5. C\u00e2y r\u00e2u m\u00e8o (Orthosiphon aristatus), \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng h\u01a1n 2000 n\u0103m trong y h\u1ecdc ng\u01b0\u1eddi Dai \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn v\u1edbi c\u00f4ng d\u1ee5ng \u201cthanh nhi\u1ec7t, l\u1ee3i ni\u1ec7u\u201d, cho th\u1ea5y ti\u1ec1m n\u0103ng l\u1edbn trong \u0111i\u1ec1u tr\u1ecb HN. Tuy nhi\u00ean, c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a n\u00f3 \u0111\u1ed1i v\u1edbi HN v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m r\u00f5.<\/p>\n\n\n\n<p>M\u1ee5c ti\u00eau nghi\u00ean c\u1ee9u (Aim of the study)<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u n\u00e0y nh\u1eb1m l\u00e0m s\u00e1ng t\u1ecf t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1eadn v\u00e0 c\u01a1 ch\u1ebf ti\u1ec1m \u1ea9n c\u1ee7a O. aristatus \u0111\u1ed1i v\u1edbi HN, s\u1eed d\u1ee5ng chi\u1ebfn l\u01b0\u1ee3c t\u00edch h\u1ee3p t\u1eadp trung v\u00e0o tr\u1ee5c ru\u1ed9t \u2013 th\u1eadn.<\/p>\n\n\n\n<p>Ph\u01b0\u01a1ng ph\u00e1p (Methods)<\/p>\n\n\n\n<p>M\u00f4 h\u00ecnh chu\u1ed9t m\u1eafc HN \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch cho u\u1ed1ng k\u1ebft h\u1ee3p potassium oxonate (750 mg\/kg) v\u00e0 acid uric (300 mg\/kg) m\u1ed7i ng\u00e0y trong 7 tu\u1ea7n.<\/p>\n\n\n\n<p>Chu\u1ed9t \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng:<\/p>\n\n\n\n<p>Cao n\u01b0\u1edbc O. aristatus li\u1ec1u th\u1ea5p ho\u1eb7c cao (3,125 ho\u1eb7c 6,25 g\/kg\/ng\u00e0y)<br>D\u00f9ng allopurinol (5 mg\/kg\/ng\u00e0y) l\u00e0m \u0111\u1ed1i ch\u1ee9ng d\u01b0\u01a1ng<\/p>\n\n\n\n<p>Ch\u1ee9c n\u0103ng th\u1eadn \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 qua:<\/p>\n\n\n\n<p>Acid uric huy\u1ebft thanh<br>Creatinin<br>Nit\u01a1 ure m\u00e1u (BUN)<\/p>\n\n\n\n<p>T\u1ed5n th\u01b0\u01a1ng v\u00e0 x\u01a1 h\u00f3a th\u1eadn \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 b\u1eb1ng:<\/p>\n\n\n\n<p>M\u00f4 b\u1ec7nh h\u1ecdc (nhu\u1ed9m H&amp;E v\u00e0 Masson)<br>H\u00f3a m\u00f4 mi\u1ec5n d\u1ecbch (\u03b1-SMA, vimentin)<br>K\u00ednh hi\u1ec3n vi \u0111i\u1ec7n t\u1eed truy\u1ec1n qua<\/p>\n\n\n\n<p>\u0110\u1ec3 l\u00e0m r\u00f5 c\u01a1 ch\u1ebf:<\/p>\n\n\n\n<p>Ph\u00e2n t\u00edch h\u1ec7 vi sinh ru\u1ed9t b\u1eb1ng gi\u1ea3i tr\u00ecnh t\u1ef1 metagenome<br>Ph\u00e2n t\u00edch chuy\u1ec3n h\u00f3a (metabolomics) b\u1eb1ng UPLC\u2013MS tr\u00ean:<br>D\u1ecbch manh tr\u00e0ng<br>M\u00f4 th\u1eadn<\/p>\n\n\n\n<p>Ngo\u00e0i ra:<\/p>\n\n\n\n<p>Bi\u1ec3u hi\u1ec7n protein li\u00ean quan \u0111\u1ebfn:<br>H\u00e0ng r\u00e0o ru\u1ed9t (Occludin, Claudin-1)<br>Con \u0111\u01b0\u1eddng t\u00edn hi\u1ec7u IDO1\/AhR<br>\u2192 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng Western blot<br>K\u1ebft qu\u1ea3 (Results)<\/p>\n\n\n\n<p>\u0110i\u1ec1u tr\u1ecb b\u1eb1ng O. aristatus gi\u00fap c\u1ea3i thi\u1ec7n r\u00f5 r\u1ec7t ch\u1ee9c n\u0103ng v\u00e0 t\u1ed5n th\u01b0\u01a1ng th\u1eadn, th\u1ec3 hi\u1ec7n qua:<\/p>\n\n\n\n<p>Gi\u1ea3m m\u1ea1nh:<br>Acid uric m\u00e1u (sUA)<br>Creatinin (Scr)<br>Nit\u01a1 ure m\u00e1u (BUN)<br>(t\u1ea5t c\u1ea3 p &lt; 0,001)<br>Gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng \u1ed1ng th\u1eadn v\u00e0 x\u01a1 h\u00f3a<\/p>\n\n\n\n<p>\u0110\u1ed3ng th\u1eddi:<\/p>\n\n\n\n<p>Ph\u1ee5c h\u1ed3i \u0111a d\u1ea1ng h\u1ec7 vi sinh ru\u1ed9t:<br>T\u0103ng ch\u1ec9 s\u1ed1 Shannon (p &lt; 0,05)<br>T\u0103ng vi khu\u1ea9n c\u00f3 l\u1ee3i Prevotella<br>Gi\u1ea3m Bacteroides<\/p>\n\n\n\n<p>Ph\u00e2n t\u00edch chuy\u1ec3n h\u00f3a cho th\u1ea5y:<\/p>\n\n\n\n<p>\u0110i\u1ec1u ch\u1ec9nh l\u1ea1i chuy\u1ec3n h\u00f3a tryptophan:<br>Gi\u1ea3m kynurenine \u1edf th\u1eadn (p &lt; 0,01)<br>T\u0103ng c\u01b0\u1eddng h\u00e0ng r\u00e0o ru\u1ed9t:<br>T\u0103ng Occludin v\u00e0 Claudin-1 (p &lt; 0,05)<\/p>\n\n\n\n<p>https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0378874125018082<\/p>\n\n\n\n<p>&#x1f449; T\u1ed5ng th\u1ec3, k\u1ebft qu\u1ea3 cho th\u1ea5y:<\/p>\n\n\n\n<p>T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1eadn c\u1ee7a O. aristatus l\u00e0 do:<br>\u1ee8c ch\u1ebf tr\u1ee5c t\u00edn hi\u1ec7u g\u00e2y x\u01a1 h\u00f3a:<br>IDO1 \/ kynurenine \/ AhR<br>Qua \u0111\u00f3 h\u00e9 l\u1ed9 c\u01a1 ch\u1ebf m\u1edbi:<br>&#x1f449; t\u01b0\u01a1ng t\u00e1c h\u1ec7 vi sinh \u2013 ch\u1ea5t chuy\u1ec3n h\u00f3a \u2013 th\u1eadn<br>K\u1ebft lu\u1eadn (Conclusion)<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u n\u00e0y l\u00e0m r\u00f5 r\u1eb1ng t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1eadn c\u1ee7a O. aristatus \u0111\u1ed1i v\u1edbi HN \u0111\u01b0\u1ee3c trung gian th\u00f4ng qua \u0111i\u1ec1u h\u00f2a tr\u1ee5c ru\u1ed9t \u2013 th\u1eadn, b\u1eb1ng c\u00e1ch:<\/p>\n\n\n\n<p>Ph\u1ee5c h\u1ed3i h\u1ec7 vi sinh<br>T\u00e1i l\u1eadp tr\u00ecnh chuy\u1ec3n h\u00f3a tryptophan c\u1ee7a c\u01a1 th\u1ec3<br>T\u1eeb \u0111\u00f3 \u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng g\u00e2y x\u01a1 h\u00f3a IDO1 \/ kynurenine \/ AhR<\/p>\n<!-- relpost-thumb-wrapper --><div class=\"relpost-thumb-wrapper\"><!-- filter-class --><div class=\"relpost-thumb-container\"><style>.relpost-block-single-image, .relpost-post-image { margin-bottom: 10px; }<\/style><h3>Related posts:<\/h3><div style=\"clear: both\"><\/div><div style=\"clear: both\"><\/div><!-- relpost-block-container --><div class=\"relpost-block-container relpost-block-column-layout\" style=\"--relposth-columns: 3;--relposth-columns_t: 2; 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 font-size: 12px;  color: #333333;\"><h2 class=\"relpost_card_title\">T\u00e0i li\u1ec7u h\u01b0\u1edbng d\u1eabn ph\u01b0\u01a1ng ph\u00e1p th\u1eed \u0111\u1ed9c t\u00ednh d\u01b0\u1ee3c li\u1ec7u sau khi b\u00e0o ch\u1ebf<\/h2><\/div><\/div><\/a><\/div><!-- close relpost-block-container --><div style=\"clear: both\"><\/div><\/div><!-- close filter class --><\/div><!-- close relpost-thumb-wrapper -->","protected":false},"excerpt":{"rendered":"<p>\u00dd ngh\u0129a d\u01b0\u1ee3c h\u1ecdc d\u00e2n t\u1ed9c (Ethnopharmacological relevance) B\u1ec7nh th\u1eadn do t\u0103ng acid uric (HN) v\u1eabn l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c trong \u0111i\u1ec1u tr\u1ecb do nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a c\u00e1c thu\u1ed1c hi\u1ec7n nay, bao g\u1ed3m hi\u1ec7u qu\u1ea3 kh\u00f4ng \u1ed5n \u0111\u1ecbnh v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5. C\u00e2y r\u00e2u m\u00e8o (Orthosiphon aristatus), \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng h\u01a1n 2000 n\u0103m &#8230; <a title=\"L\u00e0m s\u00e1ng t\u1ecf c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb c\u1ee7a c\u00e2y r\u00e2u m\u00e8o (Orthosiphon aristatus) trong b\u1ec7nh th\u1eadn do t\u0103ng acid uric\" class=\"read-more\" href=\"https:\/\/thuoc115.com\/suckhoe\/lam-sang-to-co-che-dieu-tri-cua-cay-rau-meo-orthosiphon-aristatus-trong-benh-than-do-tang-acid-uric\/\" aria-label=\"\u0110\u1ecdc th\u00eam v\u1ec1 L\u00e0m s\u00e1ng t\u1ecf c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb c\u1ee7a c\u00e2y r\u00e2u m\u00e8o (Orthosiphon aristatus) trong b\u1ec7nh th\u1eadn do t\u0103ng acid uric\">\u0110\u1ecdc ti\u1ebfp<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-543","post","type-post","status-publish","format-standard","hentry","category-duoc-lieu"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>L\u00e0m s\u00e1ng t\u1ecf c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb c\u1ee7a c\u00e2y r\u00e2u m\u00e8o (Orthosiphon aristatus) trong b\u1ec7nh th\u1eadn do t\u0103ng acid uric - Th\u00f4ng tin s\u1ee9c kh\u1ecfe<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/thuoc115.com\/suckhoe\/lam-sang-to-co-che-dieu-tri-cua-cay-rau-meo-orthosiphon-aristatus-trong-benh-than-do-tang-acid-uric\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u00e0m s\u00e1ng t\u1ecf c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb c\u1ee7a c\u00e2y r\u00e2u m\u00e8o (Orthosiphon aristatus) trong b\u1ec7nh th\u1eadn do t\u0103ng acid uric - Th\u00f4ng tin s\u1ee9c kh\u1ecfe\" \/>\n<meta property=\"og:description\" content=\"\u00dd ngh\u0129a d\u01b0\u1ee3c h\u1ecdc d\u00e2n t\u1ed9c (Ethnopharmacological relevance) B\u1ec7nh th\u1eadn do t\u0103ng acid uric (HN) v\u1eabn l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c trong \u0111i\u1ec1u tr\u1ecb do nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a c\u00e1c thu\u1ed1c hi\u1ec7n nay, bao g\u1ed3m hi\u1ec7u qu\u1ea3 kh\u00f4ng \u1ed5n \u0111\u1ecbnh v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5. 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