{"id":527,"date":"2026-03-25T20:45:17","date_gmt":"2026-03-25T20:45:17","guid":{"rendered":"https:\/\/thuoc115.com\/suckhoe\/?p=527"},"modified":"2026-03-25T22:58:36","modified_gmt":"2026-03-25T22:58:36","slug":"than-tong-duong-tam-giam-nguy-co-roi-loan-nhip-tim","status":"publish","type":"post","link":"https:\/\/thuoc115.com\/suckhoe\/than-tong-duong-tam-giam-nguy-co-roi-loan-nhip-tim\/","title":{"rendered":"Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m gi\u1ea3m nguy c\u01a1 r\u1ed1i lo\u1ea1n nh\u1ecbp tim"},"content":{"rendered":"\n<p>R\u1ed1i lo\u1ea1n nh\u1ecbp tim (Arrhythmia) l\u00e0 m\u1ed9t b\u1ec7nh tim m\u1ea1ch (CVD) ph\u1ed5 bi\u1ebfn, ch\u1ec9 b\u1ea5t k\u1ef3 b\u1ea5t th\u01b0\u1eddng n\u00e0o v\u1ec1 ngu\u1ed3n g\u1ed1c, t\u1ea7n s\u1ed1, nh\u1ecbp \u0111i\u1ec7u, v\u1eadn t\u1ed1c d\u1eabn truy\u1ec1n, th\u1eddi gian, \u0111\u01b0\u1eddng \u0111i, tr\u00ecnh t\u1ef1 ho\u1eb7c c\u00e1c kh\u00eda c\u1ea1nh kh\u00e1c c\u1ee7a xung \u0111\u1ed9ng tim, v\u00e0 l\u00e0 m\u1ed9t trong nh\u1eefng b\u1ec7nh tim m\u1ea1ch th\u01b0\u1eddng g\u1eb7p trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng. Hi\u1ec7n nay, nhi\u1ec1u lo\u1ea1i thu\u1ed1c ch\u1eb9n k\u00eanh ion \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp tim, bao g\u1ed3m ch\u1eb9n k\u00eanh ion Na+, ch\u1eb9n k\u00eanh ion K+ v\u00e0 ch\u1eb9n k\u00eanh ion Ca2+. M\u1eb7c d\u00f9 nh\u1eefng thu\u1ed1c n\u00e0y mang l\u1ea1i l\u1ee3i \u00edch, ch\u00fang \u0111\u00e3 d\u1eabn \u0111\u1ebfn s\u1ef1 gia t\u0103ng d\u1ea7n c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i li\u00ean quan \u0111\u1ebfn thu\u1ed1c tr\u00ean nhi\u1ec1u h\u1ec7 c\u01a1 quan. Do \u0111\u00f3, vi\u1ec7c t\u00ecm ki\u1ebfm c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 tr\u1edf n\u00ean c\u1ea5p thi\u1ebft. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, \u0111\u00e3 c\u00f3 m\u1ed9t s\u1ed1 ti\u1ebfn b\u1ed9 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp th\u1ea5t b\u1eb1ng y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c (TCM). L\u00fd thuy\u1ebft \u201cLo\u1ea1n B\u1ec7nh\u201d (Luobing) trong TCM \u0111\u00e3 \u0111\u1ec1 xu\u1ea5t m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c can thi\u1ec7p thu\u1ed1c m\u1edbi l\u00e0 \u201c\u0111i\u1ec1u tr\u1ecb nhanh v\u00e0 ch\u1eadm, \u0111i\u1ec1u h\u00f2a t\u1ed5ng th\u1ec3\u201d, d\u1eabn \u0111\u1ebfn s\u1ef1 chuy\u1ec3n h\u01b0\u1edbng t\u01b0 duy t\u1eeb \u201cch\u1ed1ng lo\u1ea1n nh\u1ecbp\u201d sang \u201c\u0111i\u1ec1u h\u00f2a nh\u1ecbp tim\u201d. D\u01b0\u1edbi s\u1ef1 h\u01b0\u1edbng d\u1eabn c\u1ee7a l\u00fd thuy\u1ebft n\u00e0y, vi\u1ec7c ph\u00e1t tri\u1ec3n Vi\u00ean nang Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m (Shen Song Yang Xin \u2013 SSYX) \u0111\u00e3 s\u1eed d\u1ee5ng nhi\u1ec1u th\u00e0nh ph\u1ea7n thu\u1ed1c Trung y nh\u1eb1m \u0111i\u1ec1u h\u00f2a to\u00e0n di\u1ec7n c\u01a1 ch\u1ebf \u0111i\u1ec7n sinh l\u00fd c\u01a1 tim, t\u1ea1o t\u00e1c d\u1ee5ng ch\u1ed1ng lo\u1ea1n nh\u1ecbp tr\u00ean nhi\u1ec1u k\u00eanh ion v\u00e0 c\u1ea3 c\u00e1c c\u01a1 ch\u1ebf kh\u00f4ng li\u00ean quan \u0111\u1ebfn k\u00eanh ion. T\u01b0\u01a1ng t\u1ef1, trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng, b\u1eb1ng ch\u1ee9ng d\u1ef1a tr\u00ean nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c nh\u1eadn r\u1eb1ng vi\u1ec7c k\u1ebft h\u1ee3p SSYX v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp th\u00f4ng th\u01b0\u1eddng c\u00f3 th\u1ec3 gi\u1ea3m hi\u1ec7u qu\u1ea3 h\u01a1n t\u1ea7n su\u1ea5t xu\u1ea5t hi\u1ec7n r\u1ed1i lo\u1ea1n nh\u1ecbp tim. Do \u0111\u00f3, b\u00e0i vi\u1ebft n\u00e0y cung c\u1ea5p m\u1ed9t t\u1ed5ng quan to\u00e0n di\u1ec7n v\u1ec1 th\u00e0nh ph\u1ea7n v\u00e0 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng, c\u00e1c th\u00e0nh ph\u1ea7n d\u01b0\u1ee3c l\u00fd, ph\u00e2n t\u00edch d\u01b0\u1ee3c l\u00fd m\u1ea1ng l\u01b0\u1edbi (network pharmacology) v\u00e0 \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng c\u1ee7a SSYX theo l\u00fd thuy\u1ebft Luobing, nh\u1eb1m mang \u0111\u1ebfn nh\u1eefng hi\u1ec3u bi\u1ebft gi\u00e1 tr\u1ecb cho vi\u1ec7c c\u1ea3i thi\u1ec7n qu\u1ea3n l\u00fd l\u00e2m s\u00e0ng r\u1ed1i lo\u1ea1n nh\u1ecbp tim v\u00e0 nghi\u00ean c\u1ee9u li\u00ean quan<\/p>\n\n\n\n<p>https:\/\/pubmed.ncbi.nlm.nih.gov\/39224243<\/p>\n\n\n\n<p><strong>1. Gi\u1edbi thi\u1ec7u<\/strong><br>C\u00f9ng v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n kh\u00f4ng ng\u1eebng c\u1ee7a x\u00e3 h\u1ed9i Trung Qu\u1ed1c, nh\u1eadn th\u1ee9c v\u1ec1 d\u00e2n s\u1ed1 gi\u00e0 \u0111\u00e3 xu\u1ea5t hi\u1ec7n. T\u1ef7 l\u1ec7 m\u1eafc v\u00e0 t\u1ea7n su\u1ea5t c\u00e1c b\u1ec7nh tim m\u1ea1ch (CVD) ti\u1ebfp t\u1ee5c t\u0103ng t\u1ea1i Trung Qu\u1ed1c do nhi\u1ec1u y\u1ebfu t\u1ed1, bao g\u1ed3m l\u1ed1i s\u1ed1ng kh\u00f4ng l\u00e0nh m\u1ea1nh c\u1ee7a ng\u01b0\u1eddi d\u00e2n. Theo b\u00e1o c\u00e1o s\u1ee9c kh\u1ecfe v\u00e0 b\u1ec7nh tim m\u1ea1ch Trung Qu\u1ed1c 2021, hi\u1ec7n c\u00f3 kho\u1ea3ng 330 tri\u1ec7u b\u1ec7nh nh\u00e2n tim m\u1ea1ch t\u1ea1i Trung Qu\u1ed1c, v\u00e0 t\u1ef7 l\u1ec7 t\u1eed vong v\u1eabn l\u00e0 nguy\u00ean nh\u00e2n h\u00e0ng \u0111\u1ea7u g\u00e2y ch\u1ebft ng\u01b0\u1eddi, cao h\u01a1n so v\u1edbi c\u00e1c b\u1ec7nh nh\u01b0 ung th\u01b0. Th\u1ed1ng k\u00ea cho th\u1ea5y, c\u00e1c ca t\u1eed vong do b\u1ec7nh tim m\u1ea1ch \u1edf c\u1ea3 th\u00e0nh th\u1ecb v\u00e0 n\u00f4ng th\u00f4n chi\u1ebfm h\u01a1n 40% t\u1ed5ng s\u1ed1 ca t\u1eed vong v\u00e0o n\u0103m 2019, ngh\u0129a l\u00e0 c\u1ee9 5 ca t\u1eed vong th\u00ec c\u00f3 2 ca li\u00ean quan \u0111\u1ebfn b\u1ec7nh tim m\u1ea1ch. Trong s\u1ed1 n\u00e0y, r\u1ed1i lo\u1ea1n nh\u1ecbp tim l\u00e0 nguy\u00ean nh\u00e2n tr\u1ef1c ti\u1ebfp h\u00e0ng \u0111\u1ea7u g\u00e2y t\u1eed vong \u0111\u1ed9t ng\u1ed9t v\u00e0 \u0111e d\u1ecda nghi\u00eam tr\u1ecdng \u0111\u1ebfn s\u1ee9c kh\u1ecfe v\u00e0 t\u00ednh m\u1ea1ng c\u1ee7a ng\u01b0\u1eddi d\u00e2n Trung Qu\u1ed1c.<\/p>\n\n\n\n<p>R\u1ed1i lo\u1ea1n nh\u1ecbp tim l\u00e0 t\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng ph\u1ed5 bi\u1ebfn, \u0111\u1eb7c tr\u01b0ng b\u1edfi nh\u1ecbp tim v\u00e0\/ho\u1eb7c nh\u1ecbp \u0111i\u1ec7u b\u1ea5t th\u01b0\u1eddng, c\u00f3 th\u1ec3 xu\u1ea5t ph\u00e1t t\u1eeb k\u00edch th\u00edch b\u1ea5t th\u01b0\u1eddng c\u1ee7a n\u00fat xoang ho\u1eb7c k\u00edch th\u00edch ph\u00e1t sinh t\u1eeb ngo\u00e0i n\u00fat xoang, c\u0169ng nh\u01b0 d\u1eabn truy\u1ec1n k\u00edch th\u00edch ch\u1eadm, t\u1eafc ngh\u1ebdn ho\u1eb7c d\u1eabn truy\u1ec1n b\u1ea5t th\u01b0\u1eddng qua c\u00e1c \u0111\u01b0\u1eddng d\u1eabn thay th\u1ebf. Nguy\u00ean nh\u00e2n c\u00f3 th\u1ec3 do nhi\u1ec1u y\u1ebfu t\u1ed1 nh\u01b0 b\u1ec7nh tim c\u1ea5u tr\u00fac, r\u1ed1i lo\u1ea1n c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i v\u00e0 acid-baz\u01a1, ho\u1eb7c ng\u1ed9 \u0111\u1ed9c thu\u1ed1c. R\u1ed1i lo\u1ea1n nh\u1ecbp tim c\u00f3 th\u1ec3 l\u00e0 bi\u1ec3u hi\u1ec7n \u0111\u1ea7u ti\u00ean ho\u1eb7c duy nh\u1ea5t c\u1ee7a b\u1ec7nh tim, nh\u01b0ng c\u0169ng c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n k\u00e8m v\u1edbi c\u00e1c b\u1ec7nh kh\u00e1c. Theo th\u1ed1ng k\u00ea, Trung Qu\u1ed1c c\u00f3 kho\u1ea3ng 20 tri\u1ec7u b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n nh\u1ecbp tim, v\u00e0 m\u1ed7i n\u0103m x\u1ea3y ra h\u01a1n 500.000 ca t\u1eed vong \u0111\u1ed9t ng\u1ed9t do tim, trong \u0111\u00f3 h\u01a1n 80% li\u00ean quan \u0111\u1ebfn r\u1ed1i lo\u1ea1n nh\u1ecbp nguy hi\u1ec3m. \u0110i\u1ec1u tr\u1ecb ch\u1ed1ng lo\u1ea1n nh\u1ecbp \u0111\u00e3 tr\u1edf th\u00e0nh ch\u1ee7 \u0111\u1ec1 quan tr\u1ecdng trong l\u0129nh v\u1ef1c qu\u1ea3n l\u00fd b\u1ec7nh tim m\u1ea1ch. Hi\u1ec7n nay, thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp l\u00e0 can thi\u1ec7p l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn nh\u1ea5t, gi\u00fap gi\u1ea3m \u0111\u00e1ng k\u1ec3 t\u1ea7n su\u1ea5t c\u00e1c c\u01a1n lo\u1ea1n nh\u1ecbp v\u00e0 c\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng c\u0169ng nh\u01b0 ti\u00ean l\u01b0\u1ee3ng c\u1ee7a b\u1ec7nh nh\u00e2n. Tuy nhi\u00ean, g\u1ea7n \u0111\u00e2y, t\u00ednh an to\u00e0n c\u1ee7a thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp trong \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng \u0111\u00e3 b\u1ecb \u0111\u1eb7t c\u00e2u h\u1ecfi. Nhi\u1ec1u thu\u1ed1c c\u00f3 nh\u1eefng h\u1ea1n ch\u1ebf nh\u1ea5t \u0111\u1ecbnh, bao g\u1ed3m ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i v\u00e0 kh\u1ea3 n\u0103ng g\u00e2y lo\u1ea1n nh\u1ecbp. Trong giai \u0111o\u1ea1n n\u00e0y, vi\u1ec7c ph\u00e1t tri\u1ec3n v\u00e0 ph\u1ed5 bi\u1ebfn c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp m\u1edbi, t\u1ed1i \u01b0u h\u01a1n v\u1eabn c\u00f2n ch\u1eadm. Do \u0111\u00f3, vi\u1ec7c t\u00ecm ki\u1ebfm to\u00e0n c\u1ea7u c\u00e1c thu\u1ed1c an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp tim c\u00f3 \u00fd ngh\u0129a l\u1edbn trong nghi\u00ean c\u1ee9u khoa h\u1ecdc.<\/p>\n\n\n\n<p>Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c (TCM) \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n c\u00f3 vai tr\u00f2 ch\u1ed1ng lo\u1ea1n nh\u1ecbp trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng th\u00f4ng qua c\u01a1 ch\u1ebf t\u00edch h\u1ee3p \u0111a m\u1ee5c ti\u00eau, \u0111a th\u00e0nh ph\u1ea7n, ch\u1eb9n nhi\u1ec1u k\u00eanh ion v\u00e0 \u0111i\u1ec1u h\u00f2a c\u00e1c c\u01a1 ch\u1ebf kh\u00f4ng li\u00ean quan \u0111\u1ebfn k\u00eanh ion. Vi\u00ean nang <strong>Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m (Shensong Yangxin \u2013 SSYX)<\/strong> l\u00e0 m\u1ed9t thu\u1ed1c Trung y s\u00e1ng t\u1ea1o, hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb c\u00e1c lo\u1ea1i r\u1ed1i lo\u1ea1n nh\u1ecbp tim theo l\u00fd thuy\u1ebft Luobing c\u1ee7a TCM. SSYX c\u00f3 \u01b0u \u0111i\u1ec3m \u0111i\u1ec1u h\u00f2a t\u1ed5ng th\u1ec3 theo nguy\u00ean t\u1eafc \u201c\u0111i\u1ec1u tr\u1ecb nhanh v\u00e0 ch\u1eadm, \u0111i\u1ec1u h\u00f2a t\u1ed5ng th\u1ec3\u201d m\u00e0 kh\u00f4ng g\u00e2y t\u00e1c d\u1ee5ng ph\u1ee5 lo\u1ea1n nh\u1ecbp, v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn r\u1ed9ng r\u00e3i b\u1edfi c\u00e1c chuy\u00ean gia trong ng\u00e0nh d\u1ef1a tr\u00ean nghi\u00ean c\u1ee9u y h\u1ecdc d\u1ef1a tr\u00ean b\u1eb1ng ch\u1ee9ng. B\u00e0i vi\u1ebft n\u00e0y t\u1ed5ng h\u1ee3p v\u00e0 \u0111\u00e1nh gi\u00e1 c\u00f4ng th\u1ee9c, c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng v\u00e0 \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng c\u1ee7a SSYX.<\/p>\n\n\n\n<p><strong>c\u01a1 ch\u1ebf b\u1ec7nh sinh v\u00e0 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp tim<\/strong><\/p>\n\n\n\n<p>Trong Y h\u1ecdc C\u1ed5 truy\u1ec1n Trung Qu\u1ed1c (YHCT), r\u1ed1i lo\u1ea1n nh\u1ecbp tim \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o ch\u1ee9ng <strong>\u201ch\u1ed3i h\u1ed9p\u201d, ch\u00ednh xung, t\u00e2m qu\u00fd<\/strong>. Theo l\u00fd thuy\u1ebft <strong>Lo\u1ea1n B\u1ec7nh (Luobing)<\/strong> lo\u1ea1n nh\u1ecbp tim, v\u00f9ng tim g\u1ed3m <strong>kinh kh\u00ed<\/strong> v\u00e0 <strong>m\u1ea1ch l\u1ea1c<\/strong>. <strong>Kinh kh\u00ed<\/strong> bao g\u1ed3m h\u1ec7 th\u1ed1ng d\u1eabn truy\u1ec1n tim, h\u1ec7 th\u1ea7n kinh t\u1ef1 ch\u1ee7 v\u00e0 ch\u1ee9c n\u0103ng th\u1ea7n kinh trung \u01b0\u01a1ng, trong khi <strong>m\u1ea1ch l\u1ea1c<\/strong> t\u01b0\u01a1ng \u1ee9ng v\u1edbi h\u1ec7 tu\u1ea7n ho\u00e0n v\u00e0nh. S\u1ef1 t\u01b0\u01a1ng t\u00e1c h\u00e0i h\u00f2a gi\u1eefa kinh kh\u00ed v\u00e0 m\u1ea1ch l\u1ea1c l\u00e0 y\u1ebfu t\u1ed1 then ch\u1ed1t \u0111\u1ec3 duy tr\u00ec <strong>nh\u1ecbp v\u00e0 t\u1ea7n s\u1ed1 tim b\u00ecnh th\u01b0\u1eddng<\/strong>, th\u00fac \u0111\u1ea9y <strong>tu\u1ea7n ho\u00e0n m\u00e1u<\/strong>, v\u00e0 \u0111\u1ea3m b\u1ea3o tim \u0111\u01b0\u1ee3c <strong>nu\u00f4i d\u01b0\u1ee1ng \u0111\u1ea7y \u0111\u1ee7<\/strong>.<\/p>\n\n\n\n<p>Theo YHCT, r\u1ed1i lo\u1ea1n nh\u1ecbp tim ch\u1ee7 y\u1ebfu do <strong>kh\u00ed h\u01b0, \u00e2m h\u01b0<\/strong>, m\u1ea1ch l\u1ea1c kh\u00f4ng \u0111\u01b0\u1ee3c d\u01b0\u1ee1ng, ho\u1eb7c <strong>m\u1ea1ch l\u1ea1c \u1ee9 tr\u1ec7<\/strong>. Tim ch\u1ee7 qu\u1ea3n m\u1ea1ch m\u00e1u, \u0111\u00f3ng vai tr\u00f2 trung t\u00e2m trong h\u1ec7 tu\u1ea7n ho\u00e0n. <strong>Kh\u00ed v\u00e0 huy\u1ebft c\u1ee7a t\u00e2m<\/strong> l\u00e0 \u0111\u1ed9ng l\u1ef1c ch\u00ednh v\u1eadn h\u00e0nh h\u1ec7 tu\u1ea7n ho\u00e0n <strong>t\u00e2m-huy\u1ebft-m\u1ea1ch<\/strong>. Nh\u1eefng y\u1ebfu t\u1ed1 nh\u01b0 th\u1ec3 tr\u1ea1ng k\u00e9m, \u0103n u\u1ed1ng th\u1ea5t th\u01b0\u1eddng, lao l\u1ef1c qu\u00e1 \u0111\u1ed9 c\u00f3 th\u1ec3 g\u00e2y <strong>kh\u00ed t\u00e2m b\u1ea5t t\u00fac<\/strong>, l\u00e0m <strong>huy\u1ebft v\u1eadn h\u00e0nh y\u1ebfu<\/strong>, l\u00e2u ng\u00e0y d\u1eabn \u0111\u1ebfn <strong>huy\u1ebft \u1ee9, nhi\u1ec7t n\u1ed9i<\/strong>, hao t\u1ed5n <strong>\u00e2m t\u00e2m<\/strong>, xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 <strong>h\u1ed3i h\u1ed9p, kh\u00f3 th\u1edf, t\u1ee9c ng\u1ef1c<\/strong>, do <strong>t\u00e2m kh\u00f4ng \u0111\u01b0\u1ee3c nu\u00f4i d\u01b0\u1ee1ng \u0111\u1ea7y \u0111\u1ee7<\/strong>. \u0110\u1ed3ng th\u1eddi, c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea1ng m\u1ea1ch <strong>h\u01b0 ki\u1ec7t, g\u00fat c\u1ee5c, nhanh, ho\u1eb7c gi\u00e1n \u0111o\u1ea1n<\/strong>.<\/p>\n\n\n\n<p>D\u1ef1a tr\u00ean c\u01a1 s\u1edf b\u1ec7nh l\u00fd n\u00e0y, c\u00e1c nguy\u00ean l\u00fd \u0111i\u1ec1u tr\u1ecb r\u00fat ra t\u1eeb kinh nghi\u1ec7m c\u1ee7a <strong>Tr\u01b0\u01a1ng Tr\u1ecdng C\u1ea3nh<\/strong> v\u1ec1 ch\u1ee9ng h\u1ed3i h\u1ed9p \u0111\u00e3 h\u00ecnh th\u00e0nh <strong>nguy\u00ean t\u1eafc d\u00f9ng thu\u1ed1c \u201c\u00f4n, thanh, d\u01b0\u1ee1ng, h\u00e0nh\u201d<\/strong> c\u00f9ng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb <strong>\u201cb\u1ed5 kh\u00ed d\u01b0\u1ee1ng \u00e2m, h\u00e0nh huy\u1ebft th\u00f4ng m\u1ea1ch, thanh t\u00e2m an th\u1ea7n\u201d<\/strong>. Tr\u00ean c\u01a1 s\u1edf nh\u1eefng nguy\u00ean t\u1eafc n\u00e0y, c\u00f4ng th\u1ee9c <strong>Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m (Shen Song Yangxin \u2013 SSYX)<\/strong> \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n, \u0111\u00e1nh d\u1ea5u s\u1ef1 chuy\u1ec3n h\u01b0\u1edbng t\u01b0 duy t\u1eeb <strong>\u201cch\u1ed1ng lo\u1ea1n nh\u1ecbp\u201d<\/strong> sang <strong>\u201c\u0111i\u1ec1u h\u00f2a nh\u1ecbp tim\u201d<\/strong> theo YHCT.<\/p>\n\n\n\n<p>Trong c\u00e1c s\u00e1ch y h\u1ecdc c\u1ed5 , m\u1eb7c d\u00f9 kh\u00f4ng c\u00f3 danh ph\u00e1p \u201cr\u1ed1i lo\u1ea1n nh\u1ecbp tim\u201d, nh\u01b0ng d\u1ef1a tr\u00ean bi\u1ec3u hi\u1ec7n tri\u1ec7u ch\u1ee9ng, b\u1ec7nh c\u00f3 th\u1ec3 x\u1ebfp v\u00e0o ph\u1ea1m tr\u00f9 \u201ch\u1ed3i h\u1ed9p, tim lo\u1ea1n nh\u1ecbp\u201d (\u5fc3\u60b8). Y h\u1ecdc c\u1ed5 truy\u1ec1n c\u00f3 l\u1ecbch s\u1eed l\u00e2u \u0111\u1eddi trong ch\u1ea9n tr\u1ecb ch\u1ee9ng h\u1ed3i h\u1ed9p: t\u1eeb Ho\u00e0ng \u0110\u1ebf N\u1ed9i Kinh \u0111\u00e3 ghi nh\u1eadn c\u00e1c tri\u1ec7u ch\u1ee9ng \u201ctim trong \u0111\u1eadp m\u1ea1nh, r\u1ed9n r\u00e0ng\u201d \u0111\u1ebfn Th\u01b0\u01a1ng H\u00e0n Lu\u1eadn \u0111\u01b0a ra c\u00e1c ph\u01b0\u01a1ng thu\u1ed1c c\u1ee5 th\u1ec3: \u201cTh\u01b0\u01a1ng h\u00e0n, m\u1ea1ch k\u1ebft thay, tim h\u1ed3i h\u1ed9p, ch\u1ee7 tr\u1ecb b\u1eb1ng <strong>Ch\u00edch Cam Th\u1ea3o Thang<\/strong>\u201d. Trong su\u1ed1t th\u1eddi k\u1ef3 \u0110\u01b0\u1eddng \u2013 T\u1ed1ng \u0111\u1ebfn Minh \u2013 Thanh, ki\u1ebfn th\u1ee9c v\u00e0 ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n tr\u1ecb ch\u1ee9ng h\u1ed3i h\u1ed9p kh\u00f4ng ng\u1eebng \u0111\u01b0\u1ee3c n\u00e2ng cao v\u00e0 ho\u00e0n thi\u1ec7n.<\/p>\n\n\n\n<p>X\u00e9t v\u1ec1 th\u00e0nh ph\u1ea7n, b\u00e0i thu\u1ed1c g\u1ed3m 10 v\u1ecb: Ch\u00edch cam th\u1ea3o 4 l\u01b0\u1ee3ng, Sinh kh\u01b0\u01a1ng 3 l\u01b0\u1ee3ng, \u0110\u1ea1i t\u00e1o 30 qu\u1ea3, Qu\u1ebf chi 3 l\u01b0\u1ee3ng, Nh\u00e2n s\u00e2m 2 l\u01b0\u1ee3ng, M\u1ea1ch m\u00f4n 0.5 th\u0103ng, Sinh \u0111\u1ecba 1 c\u00e2n, A giao 2 l\u01b0\u1ee3ng, H\u1ecfa ma nh\u00e2n 0.5 th\u0103ng, Ho\u00e0ng t\u1eedu 7 th\u0103ng.<\/p>\n\n\n\n<p>Trong \u0111\u00f3, Ch\u00edch cam th\u1ea3o gi\u1eef vai tr\u00f2 qu\u00e2n d\u01b0\u1ee3c v\u00ec: th\u1ee9 nh\u1ea5t, trong \u201cTh\u01b0\u01a1ng h\u00e0n lu\u1eadn\u201d, Ch\u00edch cam th\u1ea3o thang l\u00e0 ph\u01b0\u01a1ng thu\u1ed1c m\u00e0 Tr\u01b0\u01a1ng Tr\u1ecdng C\u1ea3nh d\u00f9ng Ch\u00edch cam th\u1ea3o v\u1edbi li\u1ec1u l\u01b0\u1ee3ng l\u1edbn nh\u1ea5t (4 l\u01b0\u1ee3ng), \u0111i\u1ec1u n\u00e0y nh\u1ea5n m\u1ea1nh c\u00f4ng d\u1ee5ng ho\u00e3n c\u1ea5p c\u1ee7a cam th\u1ea3o, gi\u00fap l\u00e0m gi\u1ea3m h\u1ed3i h\u1ed9p nh\u1ecbp tim nhanh; \u0111\u1ed3ng th\u1eddi ph\u1ed1i h\u1ee3p v\u1edbi Qu\u1ebf chi cay, ng\u1ecdt \u0111\u1ec3 h\u00f3a d\u01b0\u01a1ng, c\u0169ng nh\u01b0 t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng b\u1ed5 kh\u00ed c\u1ee7a Nh\u00e2n s\u00e2m; th\u1ee9 hai, b\u00e0i thu\u1ed1c n\u00e0y c\u00f3 t\u00ednh ch\u1ea5t h\u00e0n nhi\u1ec7t xen l\u1eabn, v\u00ec v\u1eady c\u1ea7n d\u00f9ng Ch\u00edch cam th\u1ea3o \u0111\u1ec3 \u0111i\u1ec1u h\u00f2a \u00e2m d\u01b0\u01a1ng.<\/p>\n\n\n\n<p>Ch\u00edch cam th\u1ea3o thang c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c xem nh\u01b0 m\u1ed9t d\u1ea1ng c\u1ee7a Qu\u1ebf chi thang b\u1ecf B\u1ea1ch th\u01b0\u1ee3c, r\u1ed3i gia th\u00eam m\u1ed9t nh\u00f3m thu\u1ed1c d\u01b0\u1ee1ng \u00e2m b\u1ed5 huy\u1ebft, thi\u00ean v\u1ec1 ch\u00fa tr\u1ecdng b\u1ed5 ph\u1ea7n \u00e2m h\u1eefu h\u00ecnh. Vi\u1ec7c b\u1ecf B\u1ea1ch th\u01b0\u1ee3c l\u00e0 th\u00f3i quen d\u00f9ng thu\u1ed1c \u0111\u1eb7c th\u00f9 c\u1ee7a Tr\u01b0\u01a1ng Tr\u1ecdng C\u1ea3nh, ch\u1ec9 c\u1ea7n g\u1eb7p tri\u1ec7u ch\u1ee9ng t\u1ee9c ng\u1ef1c, h\u1ed3i h\u1ed9p tim nhanh, \u00f4ng s\u1ebd kh\u00f4ng d\u00f9ng B\u1ea1ch th\u01b0\u1ee3c, b\u1edfi v\u00ec B\u1ea1ch th\u01b0\u1ee3c chua c\u00f3 t\u00ednh thu li\u1ec5m \u00e2m, kh\u00f4ng th\u00edch h\u1ee3p \u0111\u1ec3 s\u01a1 th\u00f4ng v\u00e0 ph\u00e1t d\u01b0\u01a1ng kh\u00ed.<\/p>\n\n\n\n<p>Ch\u00edch cam th\u1ea3o: 12\u201320g<\/p>\n\n\n\n<p>\u0110\u1ea1i t\u00e1o: 10 qu\u1ea3<\/p>\n\n\n\n<p>Nh\u00e2n s\u00e2m (ho\u1eb7c \u0110\u1ea3ng s\u00e2m): 8\u201312g<\/p>\n\n\n\n<p>Sinh \u0111\u1ecba ho\u00e0ng: 16\u201320g<\/p>\n\n\n\n<p>M\u1ea1ch m\u00f4n: 8\u201312g<\/p>\n\n\n\n<p>A giao: 8\u201312g<\/p>\n\n\n\n<p>Ma nh\u00e2n: 8\u201316g<\/p>\n\n\n\n<p>Qu\u1ebf chi: 8\u201312g<\/p>\n\n\n\n<p>G\u1eebng s\u1ed1ng: 3\u20135 l\u00e1t<\/p>\n\n\n\n<p><strong>Nguy\u00ean t\u1eafc ph\u1ed1i ch\u1ebf v\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n d\u01b0\u1ee3c ch\u1ea5t ch\u00ednh c\u1ee7a vi\u00ean nang Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m (Shensong Yangxin \u2013 SSYX)<\/strong><\/p>\n\n\n\n<p>C\u00f4ng th\u1ee9c <strong>SSYX<\/strong> d\u1ef1a tr\u00ean b\u00e0i thu\u1ed1c c\u1ed5 \u0111i\u1ec3n <strong>Th\u0103ng M\u1ea1ch Tam Thang (Shengmai SAN)<\/strong>, g\u1ed3m 12 v\u1ecb thu\u1ed1c (xem H\u00ecnh 1). Trong \u0111\u00f3:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Nh\u00e2n s\u00e2m ho\u1eb7c \u0111\u1ea3ng s\u00e2m (Ren-Shen, Panax ginseng C.A.Mey.)<\/strong> b\u1ed5 kh\u00ed T\u00e2m, d\u01b0\u1ee1ng m\u1ea1ch tim;<\/li>\n\n\n\n<li><strong>M\u1ea1ch m\u00f4n \u0111\u00f4ng (Mai-Dong, Tuber of dwarf lilyturf)<\/strong> d\u01b0\u1ee1ng \u00e2m huy\u1ebft, an th\u1ea7n, gi\u1ea3i phi\u1ec1n.<\/li>\n<\/ul>\n\n\n\n<p>C\u1eb7p thu\u1ed1c n\u00e0y t\u1ea1o th\u00e0nh <strong>\u201cqu\u00e2n d\u01b0\u1ee3c\u201d<\/strong> trong c\u00f4ng th\u1ee9c.<\/p>\n\n\n\n<p><strong>\u201cTh\u1ea7n d\u01b0\u1ee3c\u201d<\/strong> g\u1ed3m:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Tang k\u00fd sinh (Sang-Ji-Sheng, Taxillus chinensis Danse)<\/strong> v\u00e0 <strong>S\u01a1n th\u00f9 du (Shan-Zhu-Yu, Cornus officinalis Sieb. et Zucc)<\/strong> b\u1ed5 th\u1eadn, nu\u00f4i d\u01b0\u1ee1ng nguy\u00ean kh\u00ed th\u1eadn;<\/li>\n\n\n\n<li><strong>Ho\u00e0ng li\u00ean (Huang-Lian, Coptis chinensis Franch.)<\/strong> v\u00e0 <strong>\u0110an s\u00e2m (Dan-Shen, Salvia miltiorrhiza Sieb Bge.)<\/strong> thanh T\u00e2m, ho\u1ea1t huy\u1ebft.<\/li>\n<\/ul>\n\n\n\n<p>B\u1ed1n v\u1ecb n\u00e0y l\u00e0 <strong>\u201cth\u1ea7n d\u01b0\u1ee3c\u201d<\/strong> h\u1ed7 tr\u1ee3 c\u00f4ng n\u0103ng c\u1ee7a qu\u00e2n d\u01b0\u1ee3c.<\/p>\n\n\n\n<p><strong>\u201cT\u00e1 d\u01b0\u1ee3c\u201d<\/strong> g\u1ed3m:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Toan t\u00e1o nh\u00e2n (Suan-Zao-Ren, Semen ziziphi spinosae)<\/strong> v\u00e0 <strong>Ng\u0169 v\u1ecb t\u1eed (Wu-Wei-Zi, Fructus Schisandrate Chinensis)<\/strong> d\u01b0\u1ee1ng T\u00e2m, b\u1ed5 huy\u1ebft, c\u1ed1 \u00e2m T\u00e2m;<\/li>\n\n\n\n<li><strong>X\u00edch th\u01b0\u1ee3c (Chi-Shao, Radix Paeoniae Rubra)<\/strong> v\u00e0 <strong>Con gi\u00e1n \u0111\u1ea5t (Tu-Bie-Chong, Eupolyphaga sinensis Walker)<\/strong> h\u00e0nh huy\u1ebft, th\u00f4ng l\u1ea1c, gi\u1ea3m \u0111au;<\/li>\n\n\n\n<li><strong>Long c\u1ed1t (Long-Gu, x\u01b0\u01a1ng chim ho\u1eb7c x\u01b0\u01a1ng \u1ee9c)<\/strong> an th\u1ea7n, \u0111\u1ecbnh th\u1ea7n.<\/li>\n<\/ul>\n\n\n\n<p><strong>\u201cTi\u1ec1n d\u01b0\u1ee3c\u201d<\/strong> l\u00e0 <strong>Cam t\u00f9ng (Gan-Song, Radix et Rhizoma Nardostachyos)<\/strong>, nh\u1eadp kinh T\u00e2m v\u00e0 T\u1ef3, v\u1eeba b\u1ed5 kh\u00ed huy\u1ebft \u1edf kinh l\u1ea1c, v\u1eeba h\u00e0nh \u1ee9, gi\u00fap kinh m\u1ea1ch th\u00f4ng su\u1ed1t, kh\u00ed huy\u1ebft T\u00e2m \u0111\u1ea7y \u0111\u1ee7, tinh th\u1ea7n T\u00e2m y\u00ean \u0111\u1ecbnh, t\u1eeb \u0111\u00f3 ph\u1ee5c h\u1ed3i nh\u1ecbp tim b\u00ecnh th\u01b0\u1eddng. Ph\u00e2n bi\u1ec7t <strong>Radix et Rhizoma<\/strong> l\u00e0 cam th\u1ea3o kh\u00e1c nha<\/p>\n\n\n\n<p>C\u01a1 ch\u1ebf b\u1ec7nh sinh c\u01a1 b\u1ea3n c\u1ee7a r\u1ed1i lo\u1ea1n nh\u1ecbp tim trong YHCT \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng <strong>k\u1ebft h\u1ee3p \u00f4n v\u00e0 thanh, v\u1eeba th\u00f4ng su\u1ed1t v\u1eeba b\u1ed5 \u00edch<\/strong>. C\u00f4ng th\u1ee9c kh\u00f4ng ch\u1ec9 <strong>b\u1ed5 kh\u00ed \u00e2m kinh l\u1ea1c<\/strong>, m\u00e0 c\u00f2n <strong>th\u00f4ng \u1ee9 m\u1ea1ch, thanh th\u00f4ng kinh T\u00e2m<\/strong>, gi\u00fap <strong>kh\u00ed \u00e2m T\u00e2m v\u00e0 kinh l\u1ea1c \u0111\u1ea7y \u0111\u1ee7, m\u1ea1ch th\u00f4ng su\u1ed1t, tinh th\u1ea7n an \u0111\u1ecbnh<\/strong>, th\u1ec3 hi\u1ec7n <strong>\u0111i\u1ec1u h\u00f2a t\u1ed5ng h\u1ee3p c\u01a1 ch\u1ebf b\u1ec7nh sinh<\/strong>.<\/p>\n\n\n\n<p>https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/cdn.ncbi.nlm.nih.gov\/pmc\/blobs\/ee89\/11367280\/55f45b5347d3\/gr1.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<p>Trong YHCT, saponin nh\u00e2n s\u00e2m c\u00f3 t\u00e1c d\u1ee5ng b\u1ed5 T\u00e2m, c\u1ed1 b\u1ea3o c\u01a1 tim v\u00e0 c\u1ea3i thi\u1ec7n l\u01b0u th\u00f4ng huy\u1ebft d\u1ecbch. Quercetin c\u00f3 trong tang k\u00fd sinh mang t\u00ednh ch\u1ed1ng oxy h\u00f3a v\u00e0 \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p acid b\u00e9o. C\u00e1c th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a s\u01a1n tr\u00fac th\u1ee5 (Cornus officinalis) l\u00e0 strychnine, c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u v\u00e0 c\u01a1 tim, \u0111\u1ed3ng th\u1eddi ch\u1ed1ng r\u1ed1i lo\u1ea1n nh\u1ecbp tim, c\u01a1 ch\u1ebf c\u00f3 th\u1ec3 bao g\u1ed3m k\u00e9o d\u00e0i \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u01a1 tim, t\u0103ng \u0111i\u1ec7n th\u1ebf ngh\u1ec9 tuy\u1ec7t \u0111\u1ed1i, gi\u1ea3m t\u00ednh t\u1ef1 \u0111\u1ed9ng c\u1ee7a n\u00fat xoang.<\/p>\n\n\n\n<p>C\u00e1c th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc t\u1eeb ho\u00e0ng li\u00ean (Coptis chinensis) g\u1ed3m alkaloid, flavonoid, acid h\u1eefu c\u01a1 nh\u01b0 ferulic acid, trong \u0111\u00f3 berberine l\u00e0 th\u00e0nh ph\u1ea7n n\u1ed5i b\u1eadt. N\u00f3 c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf cholinesterase, t\u0103ng acetylcholine, \u0111\u1ed1i kh\u00e1ng adrenaline, gi\u00e3n m\u1ea1ch v\u00e0nh. \u0110an s\u00e2m (Salvia miltiorrhiza) ch\u1ee9a th\u00e0nh ph\u1ea7n h\u00f2a tan trong n\u01b0\u1edbc nh\u01b0 salvianolic acid A v\u00e0 B v\u00e0 tanin h\u00f2a tan trong m\u1ee1 nh\u01b0 tanshinone I v\u00e0 IIA; c\u00e1c nghi\u00ean c\u1ee9u d\u01b0\u1ee3c l\u00fd hi\u1ec7n \u0111\u1ea1i cho th\u1ea5y ch\u00fang b\u1ea3o v\u1ec7 c\u01a1 quan, gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng thi\u1ebfu m\u00e1u-t\u00e1i t\u01b0\u1edbi, ch\u1ed1ng x\u01a1 h\u00f3a v\u00e0 \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch.<\/p>\n\n\n\n<p>Saponin A c\u1ee7a t\u00e1o t\u00e0u c\u00f3 t\u00e1c d\u1ee5ng ch\u1eb9n k\u00eanh canxi, \u1ea3nh h\u01b0\u1edfng l\u00ean k\u00eanh Ca\u00b2\u207a lo\u1ea1i L c\u1ee7a t\u1ebf b\u00e0o c\u01a1 th\u1ea5t, gi\u00fap \u1ee9c ch\u1ebf nh\u1ecbp tim nhanh. Schisandrin trong ng\u0169 v\u1ecb t\u1eed l\u00e0 h\u1ee3p ch\u1ea5t xylan c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc cao, ch\u1ed1ng peroxid h\u00f3a lipid, b\u1ea3o v\u1ec7 c\u01a1 tim kh\u1ecfi t\u1ed5n th\u01b0\u01a1ng thi\u1ebfu m\u00e1u-t\u00e1i t\u01b0\u1edbi. Paeoniflorin, c\u00f9ng c\u00e1c d\u1eabn ch\u1ea5t monomer v\u00e0 acid gallic, l\u00e0 th\u00e0nh ph\u1ea7n ch\u00ednh mang nhi\u1ec1u t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd, \u0111i\u1ec1u tr\u1ecb x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch, b\u1ea3o v\u1ec7 c\u01a1 tim, ch\u1ed1ng vi\u00eam v\u00e0 gi\u1ea3m h\u00ecnh th\u00e0nh m\u1ea3ng x\u01a1 v\u1eefa. C\u00e1c th\u00e0nh ph\u1ea7n t\u1eeb \u0110\u1ecba t\u00ea c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng huy\u1ebft kh\u1ed1i, ch\u1ed1ng thi\u1ebfu m\u00e1u, \u0111i\u1ec1u h\u00f2a lipid m\u00e1u, t\u0103ng c\u01b0\u1eddng mi\u1ec5n d\u1ecbch. H\u1ee3p ch\u1ea5t terpenoid trong th\u00f4ng c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a v\u00e0 ch\u1ed1ng r\u1ed1i lo\u1ea1n nh\u1ecbp tim b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o c\u01a1 tim, \u1ed5n \u0111\u1ecbnh nh\u1ecbp tim.<\/p>\n\n\n\n<p>\u0110\u1ec3 chi\u1ebft xu\u1ea5t c\u00e1c ho\u1ea1t ch\u1ea5t trong SSYX, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p s\u1eafc k\u00fd l\u1ecfng hi\u1ec7u n\u0103ng si\u00eau cao k\u1ebft h\u1ee3p kh\u1ed1i ph\u1ed5 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao (UHPLC-Q-Orbitrap HRMS), ph\u00e2n t\u00edch \u0111\u1ecbnh t\u00ednh v\u00e0 nhanh ch\u00f3ng nh\u1eadn di\u1ec7n 54 th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc bao g\u1ed3m acid phenolic, flavonoid, terpenoid, quinone, alkaloid, d\u1ef1a tr\u00ean kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed, c\u00e1c \u0111\u1ec9nh m\u1ea3nh ion \u0111a t\u1ea7ng, th\u1eddi gian l\u01b0u, s\u1ea3n ph\u1ea9m chu\u1ea9n v\u00e0 th\u00f4ng tin tham chi\u1ebfu.<\/p>\n\n\n\n<p>Acid phenolic l\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a th\u1ee9 c\u1ea5p quan tr\u1ecdng trong d\u01b0\u1ee3c li\u1ec7u, nh\u01b0 salvianolic acid A v\u00e0 B, c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam, kh\u00e1ng khu\u1ea9n, ch\u1ed1ng oxy h\u00f3a v\u00e0 ch\u1ed1ng u.<br>Flavonoid l\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a tr\u1ecdng l\u01b0\u1ee3ng th\u1ea5p trong th\u1ef1c v\u1eadt, n\u1ed5i b\u1eadt v\u1edbi t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a, ch\u1ed1ng vi\u00eam v\u00e0 \u1ee9c ch\u1ebf h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u. Ch\u00fang c\u00f3 vai tr\u00f2 ch\u1ed1ng x\u01a1 v\u1eefa, ng\u0103n ng\u1eeba huy\u1ebft kh\u1ed1i, c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng n\u1ed9i m\u00f4, \u0111i\u1ec1u h\u00f2a lipid v\u00e0 glucose. Ngo\u00e0i ra, flavonoid c\u00f2n c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng u, ch\u1ed1ng vi\u00eam, ch\u1ed1ng oxy h\u00f3a, \u0111\u01b0\u1ee3c \u1ee9ng d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh tim m\u1ea1ch.<br>Monoterpenoid c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng u, ch\u1ed1ng oxy h\u00f3a v\u00e0 b\u1ea3o v\u1ec7 th\u1ea7n kinh.<br>Alkaloid n\u1ed5i b\u1eadt v\u1edbi c\u00e1c t\u00e1c d\u1ee5ng ch\u1ed1ng u, ch\u1ed1ng vi\u00eam, kh\u00e1ng virus, kh\u00e1ng khu\u1ea9n, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch v\u00e0 h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tim m\u1ea1ch.<\/p>\n\n\n\n<p>C\u00e1c lo\u1ea1i ho\u1ea1t ch\u1ea5t n\u00e0y ph\u1ed1i h\u1ee3p v\u1edbi nhau c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng \u0111a con \u0111\u01b0\u1eddng, \u0111a m\u1ee5c ti\u00eau, t\u1ea1o hi\u1ec7u qu\u1ea3 hi\u1ec7p \u0111\u1ed3ng v\u00e0 b\u1ed5 sung, ph\u00f9 h\u1ee3p v\u1edbi nguy\u00ean l\u00fd \u0111i\u1ec1u h\u00f2a t\u1ed5ng h\u1ee3p trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp tim theo YHCT.<\/p>\n\n\n\n<p><strong>C\u01a1 ch\u1ebf \u0111i\u1ec7n sinh l\u00fd c\u1ee7a r\u1ed1i lo\u1ea1n nh\u1ecbp tim<\/strong><\/p>\n\n\n\n<p>Tim \u0111i\u1ec1u h\u00f2a nh\u1ecbp, t\u1ea7n s\u1ed1, tr\u00ecnh t\u1ef1 v\u00e0 v\u1eadn t\u1ed1c d\u1eabn truy\u1ec1n xung, nh\u1eefng y\u1ebfu t\u1ed1 n\u00e0y r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng (AP) c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim. S\u1ef1 h\u00ecnh th\u00e0nh v\u00e0 ph\u00e2n h\u00f3a AP tim ph\u1ee5 thu\u1ed9c v\u00e0o t\u00ednh th\u1ea5m ch\u1ecdn l\u1ecdc c\u1ee7a c\u00e1c k\u00eanh ion kh\u00e1c nhau ph\u00e2n b\u1ed1 tr\u00ean m\u00e0ng c\u01a1 tim. K\u00eanh ion l\u00e0 c\u00e1c protein c\u00f3 l\u1ed7 th\u1ee7y \u01b0a tr\u00ean m\u00e0ng t\u1ebf b\u00e0o, \u0111\u00f3ng vai tr\u00f2 then ch\u1ed1t trong \u0111i\u1ec7n sinh l\u00fd c\u01a1 tim. Nh\u1eefng k\u00eanh n\u00e0y xuy\u00ean qua l\u1edbp m\u00e0ng phospholipid k\u00e9p v\u00e0 cho ph\u00e9p c\u00e1c ion nh\u1ea5t \u0111\u1ecbnh \u0111i qua m\u00e0ng t\u1ebf b\u00e0o theo c\u01a1 ch\u1ebf ch\u1ecdn l\u1ecdc. Ho\u1ea1t \u0111\u1ed9ng tu\u1ea7n t\u1ef1 c\u1ee7a c\u00e1c k\u00eanh ion tim t\u1ea1o ra AP, v\u00e0 khi t\u00ednh ch\u1ea5t \u0111i\u1ec7n sinh l\u00fd ho\u1eb7c bi\u1ec3u hi\u1ec7n ch\u1ee9c n\u0103ng c\u1ee7a c\u00e1c k\u00eanh ion n\u00e0y thay \u0111\u1ed5i, AP c\u0169ng s\u1ebd thay \u0111\u1ed5i. Do \u0111\u00f3, nh\u1eefng thay \u0111\u1ed5i \u0111i\u1ec7n sinh l\u00fd c\u01a1 tim, \u0111\u01b0\u1ee3c g\u00e2y ra b\u1edfi s\u1ef1 k\u00edch th\u00edch ho\u1eb7c \u1ee9c ch\u1ebf c\u00e1c k\u00eanh ion tim kh\u00e1c nhau, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn r\u1ed1i lo\u1ea1n nh\u1ecbp tim. \u0110i\u1ec1u n\u00e0y nh\u1ea5n m\u1ea1nh r\u1eb1ng \u0111i\u1ec1u h\u00f2a ho\u1ea1t t\u00ednh c\u1ee7a k\u00eanh ion tim l\u00e0 c\u01a1 ch\u1ebf quan tr\u1ecdng c\u1ee7a h\u1ea7u h\u1ebft c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>C\u00e1c k\u00eanh ion ch\u00ednh c\u1ee7a tim \u0111i\u1ec1u h\u00f2a d\u00f2ng ion n\u1ed9i b\u00e0o v\u00e0 d\u00f2ng \u0111i\u1ec7n ra ngo\u00e0i. D\u00f2ng \u0111i\u1ec7n v\u00e0o theo ion \u0111\u1eb7c hi\u1ec7u li\u00ean quan \u0111\u1ebfn k\u00eanh Na\u207a (INa) v\u00e0 k\u00eanh Ca\u00b2\u207a trong qu\u00e1 tr\u00ecnh kh\u1eed c\u1ef1c, trong khi d\u00f2ng ion v\u00e0o kh\u00f4ng \u0111\u1eb7c hi\u1ec7u (If) \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi si\u00eau ph\u00e2n c\u1ef1c, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t \u0111\u1ed9ng t\u1ef1 nh\u1ecbp c\u1ee7a tim. D\u00f2ng \u0111i\u1ec7n ra ngo\u00e0i bao g\u1ed3m c\u00e1c d\u00f2ng K\u207a v\u00e0 Cl\u207b ra ngo\u00e0i trong giai \u0111o\u1ea1n t\u00e1i c\u1ef1c, trong \u0111\u00f3 d\u00f2ng K\u207a ra ngo\u00e0i \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng nh\u1ea5t trong qu\u00e1 tr\u00ecnh t\u00e1i c\u1ef1c AP.<\/p>\n\n\n\n<p>C\u00e1c k\u00eanh K\u207a c\u1ee7a tim r\u1ea5t ph\u1ee9c t\u1ea1p v\u00e0 ph\u00e2n b\u1ed1 r\u1ed9ng kh\u1eafp; c\u00e2n b\u1eb1ng \u0111\u1ed9ng gi\u1eefa ch\u00eanh l\u1ec7ch n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111i\u1ec7n th\u1ebf c\u1ee7a ion K\u207a qua m\u00e0ng, k\u1ebft h\u1ee3p v\u1edbi d\u00f2ng \u0111i\u1ec7n v\u00e0o, l\u00e0 y\u1ebfu t\u1ed1 then ch\u1ed1t \u0111\u1ec3 duy tr\u00ec \u0111i\u1ec7n th\u1ebf ngh\u1ec9 c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim.<\/p>\n\n\n\n<p>5. Vai tr\u00f2 \u201c\u0111i\u1ec1u tr\u1ecb nhanh \u2013 ch\u1eadm v\u00e0 \u0111i\u1ec1u h\u00f2a t\u1ed5ng h\u1ee3p\u201d c\u1ee7a Th\u1ea7n T\u1ed1ng D\u01b0\u1ee1ng T\u00e2m ho\u00e0n (SSYX)<\/p>\n\n\n\n<p>5.1. T\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf \u0111a k\u00eanh ion c\u1ee7a SSYX<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y s\u1ef1 h\u00ecnh th\u00e0nh \u0111i\u1ec7n sinh h\u1ecdc trong t\u1ebf b\u00e0o sinh v\u1eadt c\u1ea7n s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a nhi\u1ec1u lo\u1ea1i ion v\u00e0 c\u00e1c k\u00eanh ion t\u01b0\u01a1ng \u1ee9ng \u0111\u1ec3 duy tr\u00ec kh\u1ea3 n\u0103ng k\u00edch th\u00edch c\u1ee7a t\u1ebf b\u00e0o. Qu\u00e1 tr\u00ecnh truy\u1ec1n tin gi\u1eefa c\u00e1c t\u1ebf b\u00e0o v\u00e0 trong t\u1ebf b\u00e0o di\u1ec5n ra th\u00f4ng qua c\u00e1c k\u00eanh ion tr\u00ean m\u00e0ng t\u1ebf b\u00e0o. C\u00e1c k\u00eanh ch\u1ee7 y\u1ebfu tr\u00ean m\u00e0ng t\u1ebf b\u00e0o c\u01a1 tim l\u00e0 k\u00eanh canxi, kali v\u00e0 natri. S\u1ef1 c\u00e2n b\u1eb1ng \u0111\u1ed9ng gi\u1eefa c\u00e1c ion n\u00e0y t\u1ea1o n\u00ean m\u1ed9t h\u1ec7 th\u1ed1ng m\u1ea1ng l\u01b0\u1edbi ph\u1ee9c t\u1ea1p v\u00e0 ph\u1ed1i h\u1ee3p cao, gi\u1eef vai tr\u00f2 n\u1ec1n t\u1ea3ng trong duy tr\u00ec nh\u1ecbp tim b\u00ecnh th\u01b0\u1eddng.<\/p>\n\n\n\n<p>H\u1ec7 th\u1ed1ng n\u00e0y v\u1ed1n l\u00e0 m\u1ed9t h\u1ec7 th\u1ed1ng ph\u1ee9c h\u1ee3p, c\u00f3 t\u00ednh \u1ed5n \u0111\u1ecbnh n\u1ed9i t\u1ea1i, t\u1ee9c l\u00e0 c\u00f3 kh\u1ea3 n\u0103ng duy tr\u00ec ch\u1ee9c n\u0103ng ngay c\u1ea3 khi m\u1ed9t s\u1ed1 n\u00fat trong m\u1ea1ng l\u01b0\u1edbi b\u1ecb t\u1ed5n th\u01b0\u01a1ng ho\u1eb7c b\u1ecb t\u00e1c \u0111\u1ed9ng b\u00ean ngo\u00e0i. Tuy nhi\u00ean, c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp truy\u1ec1n th\u1ed1ng th\u01b0\u1eddng t\u1eadp trung v\u00e0o m\u1ed9t m\u1ee5c ti\u00eau \u0111\u01a1n l\u1ebb v\u1edbi \u0111\u1ed9 ch\u1ecdn l\u1ecdc cao, m\u00e0 b\u1ecf qua s\u1ef1 \u0111i\u1ec1u h\u00f2a t\u1ed5ng th\u1ec3 c\u1ee7a c\u00e1c qu\u00e1 tr\u00ecnh \u0111i\u1ec7n sinh l\u00fd h\u00ecnh th\u00e0nh r\u1ed1i lo\u1ea1n nh\u1ecbp. Thu\u1ed1c truy\u1ec1n th\u1ed1ng c\u00f3 xu h\u01b0\u1edbng x\u00e1o tr\u1ed9n c\u00e2n b\u1eb1ng sinh l\u00fd trong t\u1ebf b\u00e0o c\u01a1 tim \u1edf m\u1ed9t ho\u1eb7c nhi\u1ec1u m\u1ee5c ti\u00eau, v\u01b0\u1ee3t qu\u00e1 ng\u01b0\u1ee1ng \u1ed5n \u0111\u1ecbnh n\u1ed9i t\u1ea1i, d\u1eabn \u0111\u1ebfn r\u1ed1i lo\u1ea1n \u0111i\u1ec7n sinh l\u00fd, g\u00e2y lo\u1ea1n nh\u1ecbp v\u00e0 tr\u1edf th\u00e0nh n\u00fat th\u1eaft trong \u0111i\u1ec1u tr\u1ecb l\u00e2m s\u00e0ng.<\/p>\n\n\n\n<p>Ng\u01b0\u1ee3c l\u1ea1i, YHCT n\u1ed5i b\u1eadt v\u1edbi vai tr\u00f2 l\u00e0 \u0111i\u1ec1u h\u00f2a nh\u1ecbp tim m\u1ed9t c\u00e1ch t\u1ed5ng th\u1ec3. C\u00e1c th\u00e0nh ph\u1ea7n d\u01b0\u1ee3c li\u1ec7u ph\u1ed1i h\u1ee3p trong SSYX c\u00f3 kh\u1ea3 n\u0103ng t\u00e1c \u0111\u1ed9ng hi\u1ec7p \u0111\u1ed3ng l\u00ean nhi\u1ec1u m\u1ee5c ti\u00eau k\u00eanh ion, nh\u1edd \u0111\u00f3 \u1ee9c ch\u1ebf \u0111\u1ed3ng th\u1eddi nhi\u1ec1u k\u00eanh ion, mang l\u1ea1i \u01b0u \u0111i\u1ec3m \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 \u0111\u1ed9c t\u00ednh th\u1ea5p khi s\u1eed d\u1ee5ng l\u00e2m s\u00e0ng.<\/p>\n\n\n\n<p>L\u00e0 thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn t\u1ea1i Trung Qu\u1ed1c, SSYX \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh qua nghi\u00ean c\u1ee9u y h\u1ecdc ch\u1ee9ng c\u1ee9 c\u00f3 kh\u1ea3 n\u0103ng \u0111i\u1ec1u h\u00f2a an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 nhi\u1ec1u lo\u1ea1i lo\u1ea1n nh\u1ecbp tim kh\u00e1c nhau. H\u1ea7u h\u1ebft c\u00e1c th\u00e0nh ph\u1ea7n d\u01b0\u1ee3c l\u00fd trong SSYX c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng lo\u1ea1n nh\u1ecbp \u0111\u00e1ng k\u1ec3. Nghi\u00ean c\u1ee9u cho th\u1ea5y SSYX c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf m\u1ee9c \u0111\u1ed9 kh\u00e1c nhau tr\u00ean d\u00f2ng k\u00eanh Na\u207a, d\u00f2ng k\u00eanh Ca\u00b2\u207a lo\u1ea1i L, d\u00f2ng K\u207a t\u00e1i c\u1ef1c ch\u1eadm v\u00e0 d\u00f2ng K\u207a v\u00e0o trong \u1edf k\u00eanh ion c\u01a1 th\u1ea5t tim, \u0111\u00f3ng vai tr\u00f2 ch\u1ed1ng lo\u1ea1n nh\u1ecbp ph\u1ed5 r\u1ed9ng m\u00e0 kh\u00f4ng g\u00e2y t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i li\u00ean quan \u0111\u1ebfn r\u1ed1i lo\u1ea1n nh\u1ecbp. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a SSYX tr\u00ean t\u1eebng k\u00eanh ion \u0111\u00e3 \u0111\u01b0\u1ee3c l\u00e0m r\u00f5 trong c\u00e1c nghi\u00ean c\u1ee9u.<\/p>\n\n\n\n<p><strong>5.1.1. K\u00eanh Na\u207a trong t\u1ebf b\u00e0o c\u01a1 th\u1ea5t tim<\/strong><\/p>\n\n\n\n<p><strong>K\u00eanh natri c\u00f3 \u0111i\u1ec7n \u00e1p ph\u1ee5 thu\u1ed9c (INa)<\/strong> l\u00e0 k\u00eanh ion ch\u00ednh tr\u00ean <strong>m\u00e0ng t\u1ebf b\u00e0o c\u01a1 tim<\/strong> v\u00e0 \u0111\u00f3ng vai tr\u00f2 <strong>kh\u00f4ng th\u1ec3 thi\u1ebfu trong k\u00edch th\u00edch v\u00e0 d\u1eabn truy\u1ec1n c\u1ee7a t\u1ebf b\u00e0o c\u01a1 th\u1ea5t<\/strong>. \u0110\u00e2y l\u00e0 <strong>k\u00eanh \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi k\u00edch th\u00edch<\/strong>, v\u00e0 <strong>d\u00f2ng ion Na\u207a (INa)<\/strong> l\u00e0 d\u00f2ng ch\u00ednh tham gia v\u00e0o <strong>giai \u0111o\u1ea1n kh\u1eed c\u1ef1c pha 0 (AP pha 0) \u1edf c\u00e1c t\u1ebf b\u00e0o ph\u1ea3n \u1ee9ng nhanh<\/strong>. Qu\u00e1 tr\u00ecnh <strong>kh\u1eed c\u1ef1c n\u00e0y quy\u1ebft \u0111\u1ecbnh bi\u00ean \u0111\u1ed9 AP (overshoot) v\u00e0 t\u1ed1c \u0111\u1ed9 t\u0103ng trong pha 0 c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim<\/strong>.<\/p>\n\n\n\n<p><strong>\u1ee8c ch\u1ebf INa<\/strong> s\u1ebd l\u00e0m <strong>gi\u1ea3m c\u1ea3 bi\u00ean \u0111\u1ed9 \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng (APA) v\u00e0 v\u1eadn t\u1ed1c t\u1ed1i \u0111a (Vmax)<\/strong>, t\u1eeb \u0111\u00f3 <strong>t\u0103ng ng\u01b0\u1ee1ng \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng (AP threshold)<\/strong>. \u0110\u1ed3ng th\u1eddi, c\u01a1 ch\u1ebf n\u00e0y c\u00f2n <strong>ch\u1ed1ng lo\u1ea1n nh\u1ecbp<\/strong> b\u1eb1ng c\u00e1ch <strong>tr\u00ec ho\u00e3n xung t\u00e1i v\u00e0o ho\u1eb7c v\u00f2ng h\u1ed3i l\u01b0u<\/strong>. Ngo\u00e0i ra, t\u00ecnh tr\u1ea1ng <strong>t\u00edch sodium qu\u00e1 m\u1ee9c trong t\u1ebf b\u00e0o<\/strong> c\u00f3 th\u1ec3 k\u00edch th\u00edch <strong>c\u01a1 ch\u1ebf trao \u0111\u1ed5i Na\u207a \u2013 Ca\u00b2\u207a<\/strong>, l\u00e0m <strong>t\u0103ng n\u1ed3ng \u0111\u1ed9 Ca\u00b2\u207a n\u1ed9i b\u00e0o<\/strong>, d\u1eabn \u0111\u1ebfn <strong>t\u0103ng Ca\u00b2\u207a qu\u00e1 m\u1ee9c (calcium overload)<\/strong>. Do \u0111\u00f3, <strong>\u1ee9c ch\u1ebf d\u00f2ng Na\u207a v\u00e0o v\u00e0 h\u1ea1n ch\u1ebf t\u00ecnh tr\u1ea1ng qu\u00e1 t\u1ea3i Na\u207a<\/strong> g\u00f3p ph\u1ea7n <strong>\u1ee9c ch\u1ebf lo\u1ea1n nh\u1ecbp v\u00e0 b\u1ea3o v\u1ec7 c\u01a1 tim<\/strong> \u1edf m\u1ed9t m\u1ee9c \u0111\u1ed9 nh\u1ea5t \u0111\u1ecbnh.<\/p>\n\n\n\n<p>Trong nghi\u00ean c\u1ee9u c\u1ee7a Li v\u00e0 c\u1ed9ng s\u1ef1, <strong>k\u1ef9 thu\u1eadt v\u00e1 nguy\u00ean t\u1ebf b\u00e0o (whole-cell patch clamp)<\/strong> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 kh\u1ea3o s\u00e1t t\u00e1c d\u1ee5ng c\u1ee7a SSYX tr\u00ean <strong>d\u00f2ng k\u00eanh Na\u207a v\u00e0 k\u00eanh Ca\u00b2\u207a lo\u1ea1i L (ICa-L)<\/strong> \u1edf <strong>t\u1ebf b\u00e0o c\u01a1 th\u1ea5t \u0111\u01a1n l\u1ebb c\u1ee7a chu\u1ed9t lang<\/strong>. K\u1ebft qu\u1ea3 cho th\u1ea5y <strong>SSYX l\u00e0m gi\u1ea3m m\u1eadt \u0111\u1ed9 d\u00f2ng Na\u207a c\u1ee7a t\u1ebf b\u00e0o c\u01a1 th\u1ea5t theo li\u1ec1u<\/strong>, d\u1eabn \u0111\u1ebfn <strong>d\u1ecbch \u0111\u01b0\u1eddng cong m\u1eadt \u0111\u1ed9 d\u00f2ng \u2013 \u0111i\u1ec7n th\u1ebf l\u00ean tr\u00ean<\/strong>. Tuy nhi\u00ean, SSYX <strong>kh\u00f4ng l\u00e0m thay \u0111\u1ed5i \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng, \u0111i\u1ec7n th\u1ebf c\u1ef1c \u0111\u1ea1i, \u0111i\u1ec7n th\u1ebf \u0111\u1ea3o chi\u1ec1u, hay h\u00ecnh d\u1ea1ng \u0111\u01b0\u1eddng cong<\/strong>, cho th\u1ea5y SSYX <strong>\u1ee9c ch\u1ebf INa tr\u00ean nhi\u1ec1u m\u1ee9c \u0111i\u1ec7n th\u1ebf m\u00e0ng kh\u00e1c nhau<\/strong>.<\/p>\n\n\n\n<p><strong>K\u1ebft lu\u1eadn<\/strong>, SSYX \u0111\u00f3ng vai tr\u00f2 <strong>ch\u1ed1ng lo\u1ea1n nh\u1ecbp nh\u00f3m I (Class I) b\u1eb1ng c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf k\u00eanh Na\u207a<\/strong>.<\/p>\n\n\n\n<p>5.1.2. K\u00eanh Ca\u00b2\u207a trong t\u1ebf b\u00e0o c\u01a1 tim<\/p>\n\n\n\n<p>K\u00eanh Ca\u00b2\u207a lo\u1ea1i T v\u00e0 L l\u00e0 c\u00e1c k\u00eanh ion Ca\u00b2\u207a ch\u00ednh trong tim. C\u1ea3 hai \u0111\u1ec1u l\u00e0 k\u00eanh \u0111i\u1ec7n \u00e1p ph\u1ee5 thu\u1ed9c, \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong \u0111i\u1ec1u h\u00f2a n\u1ed3ng \u0111\u1ed9 Ca\u00b2\u207a n\u1ed9i b\u00e0o, \u0111\u1ed3ng th\u1eddi g\u00f3p ph\u1ea7n h\u00ecnh th\u00e0nh giai \u0111o\u1ea1n b\u00ecnh nguy\u00ean (plateau) trong \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng (AP).<\/p>\n\n\n\n<p>K\u00eanh Ca\u00b2\u207a lo\u1ea1i L quy\u1ebft \u0111\u1ecbnh th\u1eddi gian v\u00e0 \u0111\u1ed9 b\u00ecnh nguy\u00ean c\u1ee7a AP, \u0111\u1ed3ng th\u1eddi t\u01b0\u01a1ng t\u00e1c v\u1edbi d\u00f2ng K\u207a \u0111i ra ngo\u00e0i \u0111\u1ec3 thi\u1ebft l\u1eadp c\u00e2n b\u1eb1ng d\u00f2ng ion, \u0111i\u1ec1u n\u00e0y r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec giai \u0111o\u1ea1n b\u00ecnh nguy\u00ean c\u1ee7a AP trong t\u1ebf b\u00e0o c\u01a1 tim. Khi \u0111\u1ed9 nh\u1ea1y c\u1ee7a k\u00eanh Ca\u00b2\u207a lo\u1ea1i L t\u0103ng, th\u1eddi gian AP c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim k\u00e9o d\u00e0i, d\u1eabn \u0111\u1ebfn s\u1edbm kh\u1eed c\u1ef1c sau (EAD \u2013 Early After Depolarization) v\u00e0 g\u00e2y ra lo\u1ea1n nh\u1ecbp. \u0110\u1ed3ng th\u1eddi, d\u00f2ng Ca\u00b2\u207a \u0111i v\u00e0o \u1ea3nh h\u01b0\u1edfng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn k\u00edch th\u00edch v\u00e0 co b\u00f3p t\u1ebf b\u00e0o c\u01a1 tim, c\u00f3 li\u00ean quan m\u1eadt thi\u1ebft \u0111\u1ebfn s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>Trong \u0111i\u1ec1u ki\u1ec7n b\u00ecnh th\u01b0\u1eddng, d\u00f2ng Ca\u00b2\u207a v\u00e0o v\u00e0 ra c\u00e2n b\u1eb1ng. Khi d\u00f2ng ra gi\u1ea3m ho\u1eb7c d\u00f2ng v\u00e0o t\u0103ng, t\u00ecnh tr\u1ea1ng qu\u00e1 t\u1ea3i Ca\u00b2\u207a (Ca\u00b2\u207a overload) x\u1ea3y ra, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Ca\u00b2\u207a trong l\u01b0\u1edbi n\u1ed9i c\u01a1 t\u01b0\u01a1ng, v\u00e0 khi v\u01b0\u1ee3t qu\u00e1 m\u1ee9c s\u1ebd d\u1eabn \u0111\u1ebfn gi\u1ea3i ph\u00f3ng Ca\u00b2\u207a t\u1ef1 ph\u00e1t, g\u00e2y ra kh\u1eed c\u1ef1c ch\u1eadm (delayed afterdepolarization) \u2013 nguy\u00ean nh\u00e2n trung t\u00e2m c\u1ee7a t\u1ed5n th\u01b0\u01a1ng c\u01a1 tim do thi\u1ebfu m\u00e1u \u2013 t\u00e1i t\u01b0\u1edbi m\u00e1u v\u00e0 lo\u1ea1n nh\u1ecbp. Do \u0111\u00f3, \u1ee9c ch\u1ebf k\u00eanh Ca\u00b2\u207a lo\u1ea1i L (ICa-L) kh\u00f4ng ch\u1ec9 gi\u00fap \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp m\u00e0 c\u00f2n b\u1ea3o v\u1ec7 c\u01a1 tim.<\/p>\n\n\n\n<p>Trong nghi\u00ean c\u1ee9u c\u1ee7a Zhao v\u00e0 c\u1ed9ng s\u1ef1, m\u00f4 h\u00ecnh nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p (AMI) \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch th\u1eaft nh\u00e1nh li\u00ean th\u1ea5t tr\u01b0\u1edbc c\u1ee7a \u0111\u1ed9ng m\u1ea1ch v\u00e0nh. K\u1ef9 thu\u1eadt v\u00e1 m\u00e0ng t\u1ebf b\u00e0o (patch clamp) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111o \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u01a1 tim chu\u1ed9t, trong khi k\u00ednh hi\u1ec3n vi qu\u00e9t laser (laser scanning confocal microscopy) \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111o n\u1ed3ng \u0111\u1ed9 Ca\u00b2\u207a n\u1ed9i b\u00e0o. K\u1ebft qu\u1ea3 cho th\u1ea5y SSYX k\u00e9o d\u00e0i \u0111\u00e1ng k\u1ec3 th\u1eddi gian AP c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim chu\u1ed9t v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 t\u0103ng Ca\u00b2\u207a do KCl g\u00e2y ra. Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y g\u1ee3i \u00fd r\u1eb1ng SSYX c\u00f3 th\u1ec3 ng\u0103n ng\u1eeba lo\u1ea1n nh\u1ecbp do thi\u1ebfu m\u00e1u c\u01a1 tim. C\u01a1 ch\u1ebf ti\u1ec1m n\u0103ng c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn k\u00e9o d\u00e0i AP v\u00e0 gi\u1ea3m qu\u00e1 t\u1ea3i Ca\u00b2\u207a.<\/p>\n\n\n\n<p>C\u00e1c th\u00ed nghi\u1ec7m t\u1ebf b\u00e0o c\u0169ng ch\u1ec9 ra r\u1eb1ng SSYX c\u00f3 th\u1ec3 gi\u1ea3m gi\u1ea3i ph\u00f3ng Ca\u00b2\u207a t\u1ef1 ph\u00e1t qua nhi\u1ec1u c\u01a1 ch\u1ebf, t\u1eeb \u0111\u00f3 \u0111\u1ea1t \u0111\u01b0\u1ee3c t\u00e1c d\u1ee5ng ch\u1ed1ng lo\u1ea1n nh\u1ecbp. C\u00e1c nghi\u00ean c\u1ee9u kh\u00e1c cho th\u1ea5y SSYX \u1ee9c ch\u1ebf d\u00f2ng ICa-L v\u00e0 K\u207a \u1edf t\u1ebf b\u00e0o c\u01a1 th\u1ea5t chu\u1ed9t, l\u00e0m d\u1ecbch \u0111\u01b0\u1eddng cong d\u00f2ng \u2013 \u0111i\u1ec7n th\u1ebf ICa-L l\u00ean tr\u00ean, gi\u1ea3m V1\/2 c\u1ee7a \u0111\u01b0\u1eddng cong b\u1ea5t ho\u1ea1t v\u00e0 k\u00e9o d\u00e0i th\u1eddi gian ph\u1ee5c h\u1ed3i sau b\u1ea5t ho\u1ea1t, th\u00f4ng qua c\u01a1 ch\u1ebf \u0111i\u1ec1u ch\u1ec9nh c\u1eeda k\u00eanh ph\u1ee5 thu\u1ed9c \u0111i\u1ec7n \u00e1p v\u00e0 th\u1eddi gian c\u1ee7a k\u00eanh L-type.<\/p>\n\n\n\n<p>Ngo\u00e0i ra, c\u00e1c nghi\u00ean c\u1ee9u c\u1ee7a Lian, Zhou v\u00e0 Liang cho th\u1ea5y SSYX \u1ee9c ch\u1ebf ICa-L, gi\u1ea3m t\u1ea7n su\u1ea5t c\u01a1n lo\u1ea1n nh\u1ecbp v\u00e0 b\u1ea3o v\u1ec7 c\u01a1 tim th\u00f4ng qua c\u00e1c th\u00ed nghi\u1ec7m in vivo v\u00e0 in vitro tr\u00ean nhi\u1ec1u m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt kh\u00e1c nhau. C\u01a1 ch\u1ebf n\u00e0y t\u01b0\u01a1ng t\u1ef1 v\u1edbi thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp nh\u00f3m IV.<\/p>\n\n\n\n<p>5.1.3. K\u00eanh K\u207a trong t\u1ebf b\u00e0o c\u01a1 tim<\/p>\n\n\n\n<p>Trong t\u1ebf b\u00e0o c\u01a1 tim, ion K\u207a \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c duy tr\u00ec \u0111i\u1ec7n th\u1ebf ngh\u1ec9 c\u0169ng nh\u01b0 kh\u1eed c\u1ef1c tr\u1edf l\u1ea1i (repolarization) c\u1ee7a \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng (AP). Do \u0111\u00f3, \u1ee9c ch\u1ebf c\u00e1c k\u00eanh K\u207a c\u00f3 vai tr\u00f2 c\u1ef1c k\u1ef3 quan tr\u1ecdng trong vi\u1ec7c ng\u0103n ng\u1eeba lo\u1ea1n nh\u1ecbp tim.<\/p>\n\n\n\n<p>K\u00eanh K\u207a \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i th\u00e0nh nhi\u1ec1u lo\u1ea1i, bao g\u1ed3m:<\/p>\n\n\n\n<p>K\u00eanh K\u207a \u0111i\u1ec7n \u00e1p ph\u1ee5 thu\u1ed9c (Kv)<br>K\u00eanh K\u207a ph\u1ee5 thu\u1ed9c Ca\u00b2\u207a (KCa)<br>K\u00eanh K\u207a nh\u1ea1y acetylcholine (IK(ACh))<br>K\u00eanh K\u207a nh\u1ea1y ATP (IK(ATP))<\/p>\n\n\n\n<p>Trong nh\u00f3m k\u00eanh K\u207a \u0111i\u1ec7n \u00e1p ph\u1ee5 thu\u1ed9c (Kv), c\u00e1c k\u00eanh quan tr\u1ecdng trong kh\u1eed c\u1ef1c tr\u1edf l\u1ea1i tim bao g\u1ed3m:<\/p>\n\n\n\n<p>K\u00eanh K\u207a tho\u00e1ng qua ra ngo\u00e0i (Ito)<br>K\u00eanh K\u207a ch\u1ec9nh l\u01b0u ch\u1eadm (IK)<br>K\u00eanh K\u207a ch\u1ec9nh l\u01b0u v\u00e0o trong (IK1)<\/p>\n\n\n\n<p>K\u00eanh K\u207a tho\u00e1ng qua ra ngo\u00e0i (Ito) l\u00e0 d\u00f2ng ion ch\u1ee7 y\u1ebfu ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho giai \u0111o\u1ea1n kh\u1eed c\u1ef1c s\u1edbm trong t\u1ebf b\u00e0o c\u01a1 tim, bao g\u1ed3m b\u1eaft \u0111\u1ea7u giai \u0111o\u1ea1n kh\u1eed c\u1ef1c nhanh pha-1 v\u00e0 giai \u0111o\u1ea1n b\u00ecnh nguy\u00ean pha-2 c\u1ee7a AP. Ho\u1ea1t h\u00f3a v\u00e0 b\u1ea5t ho\u1ea1t c\u1ee7a Ito tr\u1ef1c ti\u1ebfp \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00ecnh th\u00e1i v\u00e0 th\u1eddi gian AP, \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong kh\u1eed c\u1ef1c s\u1edbm v\u00e0 duy tr\u00ec \u0111i\u1ec7n th\u1ebf b\u00ecnh nguy\u00ean.<\/p>\n\n\n\n<p>Trong nghi\u00ean c\u1ee9u c\u1ee7a Zhang v\u00e0 c\u1ed9ng s\u1ef1, k\u1ef9 thu\u1eadt patch-clamp \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 quan s\u00e1t m\u1eadt \u0111\u1ed9 Ito v\u00e0 \u0111\u01b0\u1eddng cong b\u1ea5t ho\u1ea1t Ito trong c\u00e1c t\u1ebf b\u00e0o c\u01a1 tim th\u1ea5t thu\u1ed9c v\u00f9ng ngo\u1ea1i t\u00e2m m\u1ea1c (Epi), n\u1ed9i t\u00e2m m\u1ea1c (Endo) v\u00e0 trung gian (M) \u1edf v\u00f9ng r\u00eca nh\u1ed3i m\u00e1u th\u1ea5t tr\u00e1i, sau khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng SSYX. K\u1ebft qu\u1ea3 cho th\u1ea5y SSYX \u1ee9c ch\u1ebf r\u00f5 r\u1ec7t d\u00f2ng kh\u1eed c\u1ef1c do Ito \u1edf v\u00f9ng ngo\u1ea1i t\u00e2m m\u1ea1c c\u1ee7a r\u00eca nh\u1ed3i m\u00e1u, k\u00e9o d\u00e0i th\u1eddi gian APD c\u1ee7a t\u1ebf b\u00e0o c\u01a1 th\u1ea5t v\u00e0 gi\u1ea3m s\u1ef1 kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t kh\u1eed c\u1ef1c, t\u1eeb \u0111\u00f3 gi\u1ea3m nguy c\u01a1 t\u00e1i v\u00e0o pha-2 (phase-2 reentry) \u2013 m\u1ed9t hi\u1ec7n t\u01b0\u1ee3ng lo\u1ea1n nh\u1ecbp c\u1ee5c b\u1ed9.<\/p>\n\n\n\n<p>D\u00f2ng K\u207a ch\u1ec9nh l\u01b0u ch\u1eadm (IK) g\u00f3p ph\u1ea7n v\u00e0o k\u00edch ho\u1ea1t pha-2 c\u1ee7a AP v\u00e0 l\u00e0 d\u00f2ng ra ch\u1ee7 y\u1ebfu trong giai \u0111o\u1ea1n b\u00ecnh nguy\u00ean. C\u00e1c k\u00eanh n\u00e0y g\u1ed3m IKr, IKs v\u00e0 IKur:<\/p>\n\n\n\n<p>IKr \u0111\u00f3ng vai tr\u00f2 ch\u1ee7 y\u1ebfu trong duy tr\u00ec \u1ed5n \u0111\u1ecbnh th\u1eddi gian AP \u1edf t\u1ebf b\u00e0o c\u01a1 th\u1ea5t \u0111\u1ed9ng v\u1eadt l\u1edbn v\u00e0 ng\u01b0\u1eddi, v\u1edbi \u0111\u1eb7c t\u00ednh ch\u1ec9nh l\u01b0u ra ngo\u00e0i khi \u0111i\u1ec7n th\u1ebf \u00e2m v\u00e0 ch\u1ec9nh l\u01b0u v\u00e0o trong khi \u0111i\u1ec7n th\u1ebf d\u01b0\u01a1ng, b\u1ea5t ho\u1ea1t nhanh h\u01a1n k\u00edch ho\u1ea1t, r\u1ea5t quan tr\u1ecdng trong kh\u1eed c\u1ef1c tr\u1edf l\u1ea1i.<br>IKs \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong pha kh\u1eed c\u1ef1c mu\u1ed9n (pha-3) c\u1ee7a AP, l\u00e0 m\u1ee5c ti\u00eau \u0111i\u1ec1u h\u00f2a c\u1ee7a h\u1ec7 th\u1ea7n kinh giao c\u1ea3m (SNS), gi\u00fap \u1ed5n \u0111\u1ecbnh \u0111i\u1ec7n sinh l\u00fd tim. SSYX c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ph\u1ee5 thu\u1ed9c \u0111i\u1ec7n \u00e1p l\u00ean IKs, mang l\u1ea1i hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp trong nh\u1ecbp nhanh, t\u01b0\u01a1ng t\u1ef1 thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp nh\u00f3m III. Th\u00ed nghi\u1ec7m c\u0169ng cho th\u1ea5y SSYX t\u0103ng t\u1ed1c \u0111\u1ed9 b\u1ea5t ho\u1ea1t c\u1ee7a k\u00eanh v\u00e0 gi\u1ea3m nh\u1eb9 d\u00f2ng \u0111\u1ec9nh v\u00e0 d\u00f2ng \u0111u\u00f4i c\u1ee7a IKr, tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 t\u0103ng QT ph\u1ee5 thu\u1ed9c t\u1ea7n s\u1ed1 nh\u01b0 thu\u1ed1c nh\u00f3m III kh\u00e1c.<\/p>\n\n\n\n<p>K\u00eanh K\u207a ch\u1ec9nh l\u01b0u v\u00e0o trong (IK1) c\u00f3 vai tr\u00f2 \u1ed5n \u0111\u1ecbnh \u0111i\u1ec7n th\u1ebf ngh\u1ec9, h\u1ed7 tr\u1ee3 kh\u1edfi \u0111\u1ea7u kh\u1eed c\u1ef1c v\u00e0 k\u1ebft th\u00fac kh\u1eed c\u1ef1c c\u1ee7a AP. Khi \u0111i\u1ec7n th\u1ebf kh\u1eed c\u1ef1c t\u0103ng, \u0111\u1ed9 th\u1ea5m K\u207a gi\u1ea3m. T\u0103ng bi\u1ec3u hi\u1ec7n IK1 d\u1eabn \u0111\u1ebfn QT ng\u1eafn, trong khi \u1ee9c ch\u1ebf IK1 d\u1eabn \u0111\u1ebfn QT k\u00e9o d\u00e0i, do \u0111\u00f3 \u0111i\u1ec1u h\u00f2a IK1 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn k\u00edch th\u00edch tim v\u00e0 lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>Li v\u00e0 c\u1ed9ng s\u1ef1 d\u00f9ng patch-clamp to\u00e0n t\u1ebf b\u00e0o \u0111\u1ec3 quan s\u00e1t t\u00e1c d\u1ee5ng c\u1ee7a dung d\u1ecbch chi\u1ebft SSYX t\u1eeb b\u1ed9t kh\u00f4 l\u00ean d\u00f2ng K\u207a ch\u1ec9nh l\u01b0u v\u00e0o trong (IK1) \u1edf t\u1ebf b\u00e0o c\u01a1 th\u1ea5t chu\u1ed9t v\u00e0 d\u00f2ng K\u207a ch\u1ec9nh l\u01b0u ch\u1eadm (IK) \u1edf t\u1ebf b\u00e0o c\u01a1 tim chu\u1ed9t lang. Nghi\u00ean c\u1ee9u cho th\u1ea5y SSYX \u1ee9c ch\u1ebf d\u00f2ng v\u00e0o c\u1ee7a IK1, gi\u00fap duy tr\u00ec pha-4 kh\u1eed c\u1ef1c v\u00e0 gi\u1ea3m kh\u1eed c\u1ef1c ch\u1eadm sau, \u0111\u1ed3ng th\u1eddi \u1ed5n \u0111\u1ecbnh m\u00e0ng t\u1ebf b\u00e0o, lo\u1ea1i b\u1ecf s\u1edbm kh\u1eed c\u1ef1c v\u00e0 lo\u1ea1n nh\u1ecbp k\u00edch ho\u1ea1t.<\/p>\n\n\n\n<p>T\u00f3m l\u1ea1i, s\u1ef1 ph\u00e2n b\u1ed1 c\u00e1c k\u00eanh K\u207a r\u1ea5t ph\u1ee9c t\u1ea1p, m\u1ed7i k\u00eanh \u1ea3nh h\u01b0\u1edfng kh\u00e1c nhau \u0111\u1ebfn qu\u00e1 tr\u00ecnh kh\u1eed c\u1ef1c tr\u1edf l\u1ea1i c\u1ee7a AP. Do \u0111\u00f3, t\u00e1c \u0111\u1ed9ng \u0111i\u1ec7n sinh l\u00fd khi \u1ee9c ch\u1ebf t\u1eebng k\u00eanh c\u0169ng kh\u00e1c nhau. Vi\u1ec7c SSYX \u0111i\u1ec1u h\u00f2a \u0111a h\u01b0\u1edbng v\u00e0 \u1ee9c ch\u1ebf c\u00e1c k\u00eanh K\u207a c\u00f3 th\u1ec3 l\u00e0 c\u01a1 ch\u1ebf quan tr\u1ecdng gi\u00fap thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>5.1.4. K\u00eanh ion hHCN4 \u1edf c\u01a1 th\u1ea5t<\/p>\n\n\n\n<p>K\u00eanh cation k\u00edch ho\u1ea1t b\u1edfi si\u00eau c\u1ef1c h\u00f3a theo nucleotide v\u00f2ng (HCN) l\u00e0 c\u01a1 s\u1edf ph\u00e2n t\u1eed cho d\u00f2ng t\u1ea1o nh\u1ecbp If, v\u1ed1n ch\u1ee7 y\u1ebfu tham gia v\u00e0o qu\u00e1 tr\u00ecnh kh\u1eed c\u1ef1c t\u1ef1 \u0111\u1ed9ng pha-4. Trong giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a kh\u1eed c\u1ef1c t\u1ef1 \u0111\u1ed9ng, v\u1ec1 l\u00fd thuy\u1ebft, d\u00f2ng If c\u00f3 th\u1ec3 gi\u1ea3m nguy c\u01a1 lo\u1ea1n nh\u1ecbp d\u01b0\u1edbi \u0111i\u1ec1u ki\u1ec7n \u0111i\u1ec7n sinh l\u00fd b\u00ecnh th\u01b0\u1eddng m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn th\u1eddi gian kh\u1eed c\u1ef1c tr\u1edf l\u1ea1i (repolarization) c\u1ee7a AP.<\/p>\n\n\n\n<p>Ng\u01b0\u1ee3c l\u1ea1i, trong tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh l\u00fd, tim c\u00f3 hi\u1ec7n t\u01b0\u1ee3ng t\u0103ng bi\u1ec3u hi\u1ec7n mRNA v\u00e0 protein hHCN4, d\u1eabn \u0111\u1ebfn t\u0103ng d\u00f2ng t\u1ea1o nh\u1ecbp, \u0111\u1eb7c bi\u1ec7t r\u00f5 \u1edf b\u1ec7nh nh\u00e2n thi\u1ebfu m\u00e1u c\u01a1 tim. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n giai \u0111o\u1ea1n cu\u1ed1i c\u1ee7a b\u1ec7nh thi\u1ebfu m\u00e1u c\u01a1 tim, s\u1ef1 t\u0103ng bi\u1ec3u hi\u1ec7n hHCN4 l\u00e0m d\u00f2ng t\u1ea1o nh\u1ecbp trong t\u1ebf b\u00e0o c\u01a1 th\u1ea5t t\u0103ng h\u01a1n hai l\u1ea7n, \u0111\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n quan tr\u1ecdng g\u00e2y lo\u1ea1n nh\u1ecbp \u00e1c t\u00ednh. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng \u0111i\u1ec1u ch\u1ec9nh bi\u1ec3u hi\u1ec7n HCN4 th\u00f4ng qua k\u1ef9 thu\u1eadt t\u00e1i c\u1ea5u tr\u00fac \u0111i\u1ec7n sinh l\u00fd c\u00f3 th\u1ec3 l\u00e0 c\u01a1 ch\u1ebf quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb ch\u1ed1ng lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>Sun v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 s\u1eed d\u1ee5ng b\u1ed9t kh\u00f4 SSYX \u0111\u1ec3 pha dung d\u1ecbch n\u1ed3ng \u0111\u1ed9 0,5 %, d\u00f9ng d\u1ecbch ngo\u1ea1i b\u00e0o l\u00e0m dung m\u00f4i. Dung d\u1ecbch n\u00e0y \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 chuy\u1ec3n gen hHCN4 cDNA (m\u1ed9t k\u00eanh cation k\u00edch ho\u1ea1t b\u1edfi si\u00eau c\u1ef1c h\u00f3a \u1edf ng\u01b0\u1eddi, gene If) v\u00e0o t\u1ebf b\u00e0o th\u1eadn ph\u00f4i ng\u01b0\u1eddi HEK293, sau \u0111\u00f3 ghi nh\u1eadn d\u00f2ng ion k\u00edch ho\u1ea1t b\u1edfi si\u00eau c\u1ef1c h\u00f3a b\u1eb1ng k\u1ef9 thu\u1eadt patch-clamp to\u00e0n t\u1ebf b\u00e0o. K\u1ebft qu\u1ea3 cho th\u1ea5y SSYX \u1ee9c ch\u1ebf m\u1eadt \u0111\u1ed9 d\u00f2ng \u0111\u1ec9nh trong t\u1ebf b\u00e0o HEK293. Ngo\u00e0i ra, s\u1ef1 \u1ee9c ch\u1ebf n\u00e0y c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c, d\u00f2ng ion c\u00f3 th\u1ec3 kh\u00f4i ph\u1ee5c m\u1ed9t ph\u1ea7n so v\u1edbi d\u00f2ng ban \u0111\u1ea7u sau khi r\u1eeda, th\u1ec3 hi\u1ec7n \u0111i\u1ec1u h\u00f2a hai chi\u1ec1u.<\/p>\n\n\n\n<p>Nh\u01b0 v\u1eady, d\u00f2ng t\u1ea1o nh\u1ecbp xu\u1ea5t ph\u00e1t t\u1eeb hHCN4 c\u00f3 th\u1ec3 b\u1ecb \u1ee9c ch\u1ebf \u0111\u1ea3o ng\u01b0\u1ee3c b\u1edfi dung d\u1ecbch b\u1ed9t kh\u00f4 SSYX, cung c\u1ea5p m\u1ed9t gi\u1ea3 thuy\u1ebft m\u1edbi v\u1ec1 c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp c\u1ee7a SSYX.<\/p>\n\n\n\n<p>5.2. T\u00e1c d\u1ee5ng \u0111i\u1ec1u h\u00f2a c\u1ee7a vi\u00ean nang Shensong Yangxin tr\u00ean c\u00e1c y\u1ebfu t\u1ed1 ngo\u00e0i k\u00eanh ion<\/p>\n\n\n\n<p>5.2.1. C\u1ea3i thi\u1ec7n c\u1ea5u tr\u00fac \u0111i\u1ec7n sinh l\u00fd c\u1ee7a c\u01a1 tim<\/p>\n\n\n\n<p>Qu\u1ea7n th\u1ec3 t\u1ebf b\u00e0o tim g\u1ed3m c\u01a1 tim b\u1ea3n th\u1ec3 (intrinsic myocardium) v\u00e0 c\u01a1 tim chuy\u00ean bi\u1ec7t (specialized myocardium). C\u00e1c t\u1ebf b\u00e0o d\u1eabn truy\u1ec1n nh\u01b0 n\u00fat xoang, n\u00fat nh\u0129-th\u1ea5t, v\u00e0 s\u1ee3i Purkinje ch\u1ecbu tr\u00e1ch nhi\u1ec7m truy\u1ec1n xung \u0111i\u1ec7n \u0111\u1ebfn c\u00e1c t\u1ebf b\u00e0o c\u01a1 l\u00e0m vi\u1ec7c (working myocytes). Khi nh\u1eadn xung \u0111i\u1ec7n n\u00e0y, c\u00e1c t\u1ebf b\u00e0o c\u01a1 l\u00e0m vi\u1ec7c t\u1ea1o ra co b\u00f3p k\u00edch th\u00edch. N\u1ebfu li\u00ean k\u1ebft gi\u1eefa t\u1ebf b\u00e0o d\u1eabn truy\u1ec1n v\u00e0 t\u1ebf b\u00e0o c\u01a1 b\u1ecb gi\u00e1n \u0111o\u1ea1n, kh\u1ea3 n\u0103ng k\u00edch th\u00edch v\u00e0 d\u1eabn truy\u1ec1n s\u1ebd b\u1ecb \u1ea3nh h\u01b0\u1edfng, d\u1eabn \u0111\u1ebfn lo\u1ea1n nh\u1ecbp tim. Trong s\u1ed1 c\u00e1c t\u1ebf b\u00e0o d\u1eabn truy\u1ec1n, n\u00fat xoang \u0111\u00f3ng vai tr\u00f2 m\u00e1y t\u1ea1o nh\u1ecbp, sinh nh\u1ecbp xoang b\u00ecnh th\u01b0\u1eddng. R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u00fat xoang c\u00f3 th\u1ec3 g\u00e2y ra b\u1ea5t th\u01b0\u1eddng v\u1ec1 d\u1eabn truy\u1ec1n v\u00e0 t\u1ea1o nh\u1ecbp, t\u1eeb \u0111\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ea7n s\u1ed1 v\u00e0 nh\u1ecbp tim.<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng SSYX c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n nh\u1ecbp tim xoang, r\u00fat ng\u1eafn th\u1eddi gian d\u1eabn truy\u1ec1n n\u00fat xoang, th\u1eddi gian h\u1ed3i ph\u1ee5c v\u00e0 th\u1eddi gian d\u1eabn truy\u1ec1n nh\u0129-th\u1ea5t \u1edf l\u1ee3n mini Trung Qu\u1ed1c tr\u01b0\u1edfng th\u00e0nh, t\u1eeb \u0111\u00f3 t\u0103ng c\u01b0\u1eddng ch\u1ee9c n\u0103ng n\u00fat xoang v\u00e0 d\u1eabn truy\u1ec1n tim, \u0111\u00f3ng vai tr\u00f2 \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp m\u1ea1n t\u00ednh.<\/p>\n\n\n\n<p>\u0110\u01b0\u1ee3c bi\u1ebft, th\u1eddi gian \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng (APD) c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1edfi s\u1ef1 di chuy\u1ec3n ion xuy\u00ean m\u00e0ng. APD \u0111\u01b0\u1ee3c quy\u1ebft \u0111\u1ecbnh b\u1edfi s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa d\u00f2ng v\u00e0o v\u00e0 d\u00f2ng ra trong giai \u0111o\u1ea1n t\u00e1i c\u1ef1c (repolarization). T\u0103ng d\u00f2ng v\u00e0o ho\u1eb7c gi\u1ea3m d\u00f2ng ra s\u1ebd d\u1eabn \u0111\u1ebfn k\u00e9o d\u00e0i APD, v\u00e0 ng\u01b0\u1ee3c l\u1ea1i. Nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng k\u00e9o d\u00e0i APD qu\u00e1 m\u1ee9c v\u00e0 r\u00fat ng\u1eafn th\u1eddi gian tr\u01a1 hi\u1ec7u qu\u1ea3 (ERP) l\u00e0 nh\u1eefng ch\u1ec9 d\u1ea5u quan tr\u1ecdng c\u1ee7a t\u00e1i c\u1ea5u tr\u00fac \u0111i\u1ec7n sinh l\u00fd do b\u1ea5t th\u01b0\u1eddng \u0111i\u1ec7n sinh l\u00fd, c\u00f3 th\u1ec3 g\u00e2y ra b\u1ea5t th\u01b0\u1eddng d\u1eabn truy\u1ec1n v\u00e0 t\u00e1i nh\u1eadp, v\u1ed1n l\u00e0 c\u01a1 ch\u1ebf ch\u00ednh c\u1ee7a lo\u1ea1n nh\u1ecbp th\u1ea5t.<\/p>\n\n\n\n<p>Trong nghi\u00ean c\u1ee9u v\u1ec1 t\u00e1i c\u1ea5u tr\u00fac \u0111i\u1ec7n \u1edf chu\u1ed9t Wistar b\u1ecb h\u1ed9i ch\u1ee9ng chuy\u1ec3n h\u00f3a (MetS), Yang v\u00e0 c\u1ed9ng s\u1ef1 ph\u00e1t hi\u1ec7n r\u1eb1ng chu\u1ed9t \u0103n ch\u1ebf \u0111\u1ed9 nhi\u1ec1u carbohydrate v\u00e0 nhi\u1ec1u ch\u1ea5t b\u00e9o d\u1ec5 b\u1ecb lo\u1ea1n nh\u1ecbp th\u1ea5t, li\u00ean quan \u0111\u1ebfn ERP r\u00fat ng\u1eafn v\u00e0 APD k\u00e9o d\u00e0i. C\u00e1c thay \u0111\u1ed5i \u0111i\u1ec7n sinh l\u00fd do MetS g\u00e2y ra \u0111\u01b0\u1ee3c \u0111\u1ea3o ng\u01b0\u1ee3c sau khi can thi\u1ec7p b\u1eb1ng SSYX.<\/p>\n\n\n\n<p>M\u1ed9t nghi\u00ean c\u1ee9u \u0111i\u1ec7n sinh l\u00fd kh\u00e1c tr\u00ean m\u00f4 h\u00ecnh th\u1ecf suy tim, \u0111\u01b0\u1ee3c Wang v\u00e0 c\u1ed9ng s\u1ef1 x\u00e1c nh\u1eadn, cho th\u1ea5y SSYX c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh c\u00e1c thay \u0111\u1ed5i \u0111i\u1ec7n sinh l\u00fd tim do t\u0103ng t\u1ea3i tr\u01b0\u1edbc v\u00e0 sau tim, c\u1ee5 th\u1ec3 r\u00fat ng\u1eafn APD c\u1ee7a c\u01a1 nh\u0129 v\u00e0 \u0111\u01b0a \u0111\u1eb7c t\u00ednh \u0111i\u1ec7n sinh l\u00fd nh\u0129 v\u1ec1 g\u1ea7n tr\u1ea1ng th\u00e1i sinh l\u00fd b\u00ecnh th\u01b0\u1eddng. Trong th\u00ed nghi\u1ec7m n\u00e0y, SSYX c\u00f2n gi\u1ea3m s\u1ef1 ph\u00e2n t\u00e1n xuy\u00ean th\u00e0nh c\u1ee7a t\u00e1i c\u1ef1c (TDR) v\u00e0 n\u00e2ng ng\u01b0\u1ee1ng rung th\u1ea5t (VFT), g\u00f3p ph\u1ea7n ch\u1ed1ng lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u kh\u00e1c c\u0169ng x\u00e1c nh\u1eadn r\u1eb1ng SSYX c\u00f3 th\u1ec3 k\u00e9o d\u00e0i ERP v\u00e0 VFT, \u0111\u1ed3ng th\u1eddi r\u00fat ng\u1eafn RDR trong m\u00f4 h\u00ecnh t\u00e1i c\u1ea5u tr\u00fac th\u1ea5t do th\u1eaft \u0111\u1ed9ng m\u1ea1ch v\u00e0nh tr\u00e1i. Nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y nh\u1ea5t qu\u00e1n v\u1edbi c\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc, cho th\u1ea5y SSYX t\u00e1c \u0111\u1ed9ng ch\u1ed1ng lo\u1ea1n nh\u1ecbp th\u00f4ng qua \u1ea3nh h\u01b0\u1edfng l\u00ean c\u00e1c \u0111\u1eb7c t\u00ednh \u0111i\u1ec7n sinh l\u00fd tim b\u1eb1ng nhi\u1ec1u con \u0111\u01b0\u1eddng kh\u00e1c nhau.<\/p>\n\n\n\n<p>5.2.2. \u1ee8c ch\u1ebf x\u01a1 h\u00f3a c\u01a1 tim<\/p>\n\n\n\n<p>V\u1ec1 m\u1eb7t sinh l\u00fd, t\u1ebf b\u00e0o nguy\u00ean b\u00e0o s\u1ee3i (fibroblast) th\u01b0\u1eddng \u1edf tr\u1ea1ng th\u00e1i ng\u1ee7 ngh\u1ec9, trong khi s\u1ef1 h\u00ecnh th\u00e0nh v\u00e0 ph\u00e2n gi\u1ea3i collagen trong ma tr\u1eadn ngo\u1ea1i b\u00e0o (ECM) duy tr\u00ec m\u1ed9t c\u00e2n b\u1eb1ng \u0111\u1ed9ng. Tuy nhi\u00ean, d\u01b0\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n b\u1ec7nh l\u00fd, m\u1ed9t lo\u1ea1t cytokine nh\u01b0 angiotensin II v\u00e0 TGF-\u03b2 c\u00f9ng c\u00e1c y\u1ebfu t\u1ed1 ngo\u1ea1i sinh nh\u01b0 c\u0103ng c\u01a1 h\u1ecdc k\u00edch th\u00edch t\u1ebf b\u00e0o nguy\u00ean b\u00e0o s\u1ee3i t\u0103ng sinh v\u00e0 bi\u1ec7t h\u00f3a th\u00e0nh myofibroblast, v\u1edbi kh\u1ea3 n\u0103ng t\u0103ng t\u1ed5ng h\u1ee3p v\u00e0 ti\u1ebft c\u00e1c th\u00e0nh ph\u1ea7n ECM v\u00e0 l\u00e0m m\u1ea5t c\u00e2n b\u1eb1ng gi\u1eefa metalloproteinase ma tr\u1eadn (MMPs) v\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf c\u1ee7a ch\u00fang (TIMPs).<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng c\u00e2n b\u1eb1ng MMP\/TIMP l\u00e0 y\u1ebfu t\u1ed1 then ch\u1ed1t \u0111\u1ec3 duy tr\u00ec s\u1ef1 c\u00e2n b\u1eb1ng gi\u1eefa t\u1ed5ng h\u1ee3p collagen v\u00e0 ph\u00e2n gi\u1ea3i chuy\u1ec3n h\u00f3a trong t\u1ebf b\u00e0o nguy\u00ean b\u00e0o s\u1ee3i c\u01a1 tim. S\u1ef1 t\u0103ng ho\u1ea1t t\u00ednh MMP ho\u1eb7c m\u1ea5t c\u00e2n b\u1eb1ng nghi\u00eam tr\u1ecdng trong t\u1ef7 l\u1ec7 MMP\/TIMP s\u1ebd d\u1eabn \u0111\u1ebfn t\u00e1i c\u1ea5u tr\u00fac th\u1ea5t v\u00e0 x\u01a1 h\u00f3a c\u01a1 tim. Tuy nhi\u00ean, ho\u1ea1t t\u00ednh MMP qu\u00e1 cao c\u00f3 th\u1ec3 ph\u00e2n gi\u1ea3i collagen b\u00ecnh th\u01b0\u1eddng, \u0111\u01b0\u1ee3c thay th\u1ebf b\u1eb1ng m\u00f4 li\u00ean k\u1ebft x\u01a1, g\u00e2y t\u1ed5n th\u01b0\u01a1ng nghi\u00eam tr\u1ecdng m\u1ea1ng l\u01b0\u1edbi collagen tim, l\u00e0 m\u1ed9t trong nh\u1eefng y\u1ebfu t\u1ed1 ch\u00ednh g\u00e2y bi\u1ebfn \u0111\u1ed9ng nh\u1ecbp tim.<\/p>\n\n\n\n<p>Trong m\u00f4 h\u00ecnh chu\u1ed9t t\u00e1i c\u1ea5u tr\u00fac th\u1ea5t do th\u1eaft \u0111\u1ed9ng m\u1ea1ch ch\u1ee7, ng\u01b0\u1eddi ta quan s\u00e1t th\u1ea5y SSYX thay \u0111\u1ed5i h\u00ecnh th\u00e1i b\u1ec7nh l\u00fd, gi\u1ea3m x\u01a1 h\u00f3a c\u01a1 tim \u1edf chu\u1ed9t t\u00e1i c\u1ea5u tr\u00fac \u0111\u1ed3ng t\u00e2m, n\u00e2ng cao \u0111\u00e1ng k\u1ec3 ng\u01b0\u1ee1ng rung th\u1ea5t v\u00e0 r\u00fat ng\u1eafn th\u1eddi gian rung th\u1ea5t.<\/p>\n\n\n\n<p>TGF-\u03b21 c\u00f3 th\u1ec3 k\u00edch th\u00edch t\u1ed5ng h\u1ee3p collagen v\u00e0 t\u0103ng bi\u1ec3u hi\u1ec7n MMP, g\u00f3p ph\u1ea7n v\u00e0o x\u01a1 h\u00f3a c\u01a1 tim. Ma v\u00e0 c\u1ed9ng s\u1ef1 ph\u00e1t hi\u1ec7n r\u1eb1ng SSYX gi\u1ea3m x\u01a1 h\u00f3a nh\u0129 tr\u00e1i, h\u1ea1 th\u1ea5p bi\u1ec3u hi\u1ec7n TGF-\u03b21, MMP-9, TIMP-1, collagen lo\u1ea1i I v\u00e0 III, \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o nguy\u00ean b\u00e0o s\u1ee3i th\u00e0nh myofibroblast, c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng d\u1eabn truy\u1ec1n nh\u0129 tr\u00e1i, v\u00e0 gi\u1ea3m nguy c\u01a1 rung nh\u0129 sau nh\u1ed3i m\u00e1u c\u01a1 tim.<\/p>\n\n\n\n<p>M\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c ch\u1ec9 ra \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u TGF-\u03b21\/Smad tham gia v\u00e0o qu\u00e1 tr\u00ecnh x\u01a1 h\u00f3a c\u01a1 tim \u1edf b\u1ec7nh c\u01a1 tim do ti\u1ec3u \u0111\u01b0\u1eddng. SSYX c\u00f3 th\u1ec3 gi\u1ea3m x\u01a1 h\u00f3a c\u01a1 tim v\u00e0 l\u1eafng \u0111\u1ecdng collagen \u1edf chu\u1ed9t ti\u1ec3u \u0111\u01b0\u1eddng type 2, t\u1eeb \u0111\u00f3 tr\u00ec ho\u00e3n s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a lo\u1ea1n nh\u1ecbp nguy hi\u1ec3m th\u00f4ng qua \u1ee9c ch\u1ebf \u0111\u01b0\u1eddng t\u00edn hi\u1ec7u TGF-\u03b21\/Smad.<\/p>\n\n\n\n<p>X\u01a1 h\u00f3a c\u01a1 tim th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn t\u00e1i c\u1ea5u tr\u00fac c\u00e1c khe li\u00ean k\u1ebft (gap junction) c\u1ee7a tim, l\u00e0 y\u1ebfu t\u1ed1 quan tr\u1ecdng trong ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh tim m\u1ea1ch (CVD), bao g\u1ed3m lo\u1ea1n nh\u1ecbp v\u00e0 suy tim. C\u00e1c khe li\u00ean k\u1ebft l\u00e0 ph\u01b0\u01a1ng th\u1ee9c k\u1ebft n\u1ed1i ch\u00ednh c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim, duy tr\u00ec k\u1ebft n\u1ed1i \u0111i\u1ec7n b\u00ecnh th\u01b0\u1eddng, \u0111\u01b0\u1ee3c c\u1ea5u t\u1ea1o t\u1eeb connexin (Cx) 43 v\u00e0 Cx40. Trong \u0111\u00f3, Cx40 bi\u1ec3u hi\u1ec7n \u1edf t\u1ebf b\u00e0o c\u01a1 nh\u0129, c\u00f2n Cx43 xu\u1ea5t hi\u1ec7n \u1edf c\u1ea3 t\u1ebf b\u00e0o c\u01a1 nh\u0129 v\u00e0 th\u1ea5t.<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng s\u1ef1 gi\u1ea3i ph\u00f3ng TNF-\u03b1 b\u1edfi myoblasts sau nh\u1ed3i m\u00e1u c\u01a1 tim c\u00f3 th\u1ec3 g\u00e2y ra x\u01a1 h\u00f3a nh\u0129 b\u1ec7nh l\u00fd \u1edf chu\u1ed9t th\u00f4ng qua \u0111\u01b0\u1eddng t\u00edn hi\u1ec7u TGF-\u03b2 v\u00e0 c\u00e1c con \u0111\u01b0\u1eddng kh\u00e1c. Trong qu\u00e1 tr\u00ecnh n\u00e0y, bi\u1ec3u hi\u1ec7n Cx40 v\u00e0 Cx43 thay \u0111\u1ed5i, v\u00e0 nh\u1eefng thay \u0111\u1ed5i n\u00e0y c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 xu\u1ea5t hi\u1ec7n v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 c\u01a1 ch\u1ebf lo\u1ea1n nh\u1ecbp sau nh\u1ed3i m\u00e1u c\u01a1 tim cho th\u1ea5y SSYX t\u0103ng bi\u1ec3u hi\u1ec7n Cx43 trong m\u00f4 c\u01a1 tim, gi\u1ea3m l\u1eafng \u0111\u1ecdng s\u1ee3i collagen v\u00e0 th\u1ec3 t\u00edch collagen, l\u00e0m ch\u1eadm ti\u1ebfn tri\u1ec3n x\u01a1 h\u00f3a c\u01a1 tim, v\u00e0 gi\u1ea3m t\u1ef7 l\u1ec7 lo\u1ea1n nh\u1ecbp nguy hi\u1ec3m. T\u01b0\u01a1ng t\u1ef1, SSYX k\u00edch th\u00edch bi\u1ec3u hi\u1ec7n Cx40 \u1edf c\u01a1 nh\u0129 c\u1ee7a chu\u1ed9t ti\u1ec3u \u0111\u01b0\u1eddng, nh\u01b0ng \u00edt \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ph\u00e2n b\u1ed1 kh\u00f4ng gian c\u1ee7a n\u00f3; nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y v\u1eabn c\u1ea7n nghi\u00ean c\u1ee9u th\u00eam.<\/p>\n\n\n\n<p>5.2.3. \u0110i\u1ec1u h\u00f2a ch\u1ee9c n\u0103ng th\u1ea7n kinh t\u1ef1 ch\u1ee7 tim<\/p>\n\n\n\n<p>Trong \u0111i\u1ec1u ki\u1ec7n b\u00ecnh th\u01b0\u1eddng, h\u1ec7 th\u1ea7n kinh t\u1ef1 ch\u1ee7 (ANS) \u0111i\u1ec1u h\u00f2a tim b\u1eb1ng c\u00e1ch duy tr\u00ec c\u00e2n b\u1eb1ng gi\u1eefa ho\u1ea1t \u0111\u1ed9ng c\u1ee7a d\u00e2y th\u1ea7n kinh ph\u1ebf v\u1ecb (vagus) v\u00e0 th\u1ea7n kinh giao c\u1ea3m, trong khi ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh \u0111i\u1ec1u ch\u1ec9nh c\u00e1c \u0111\u1eb7c t\u00ednh sinh l\u00fd c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim. K\u00edch th\u00edch th\u1ea7n kinh giao c\u1ea3m d\u1eabn \u0111\u1ebfn k\u00edch th\u00edch t\u1ebf b\u00e0o c\u01a1 tim, trong khi t\u00edn hi\u1ec7u t\u1eeb t\u1ebf b\u00e0o c\u01a1 tim c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t d\u00e2y th\u1ea7n kinh ph\u1ebf v\u1ecb. M\u1ea5t c\u00e2n b\u1eb1ng trong \u0111i\u1ec1u h\u00f2a c\u1ee7a hai h\u1ec7 th\u1ed1ng n\u00e0y c\u00f3 th\u1ec3 g\u00e2y ra r\u1ed1i lo\u1ea1n \u0111i\u1ec7n sinh l\u00fd b\u1ea5t th\u01b0\u1eddng, d\u1eabn \u0111\u1ebfn lo\u1ea1n nh\u1ecbp tim.<\/p>\n\n\n\n<p>Bi\u1ebfn thi\u00ean nh\u1ecbp tim (HRV) l\u00e0 m\u1ed9t ch\u1ec9 s\u1ed1 ph\u1ed5 bi\u1ebfn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a c\u00e2n b\u1eb1ng th\u1ea7n kinh giao c\u1ea3m v\u00e0 ph\u1ebf v\u1ecb l\u00ean h\u1ec7 tim m\u1ea1ch, th\u01b0\u1eddng d\u00f9ng \u0111\u1ec3 ph\u1ea3n \u00e1nh ch\u1ee9c n\u0103ng \u0111i\u1ec1u h\u00f2a c\u1ee7a h\u1ec7 th\u1ea7n kinh t\u1ef1 ch\u1ee7. HRV t\u0103ng khi ho\u1ea1t \u0111\u1ed9ng c\u1ee7a d\u00e2y ph\u1ebf v\u1ecb t\u0103ng v\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a th\u1ea7n kinh giao c\u1ea3m gi\u1ea3m. Trong HRV, th\u00e0nh ph\u1ea7n t\u1ea7n s\u1ed1 th\u1ea5p (LF) \u0111\u1ea1i di\u1ec7n cho ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh giao c\u1ea3m, trong khi th\u00e0nh ph\u1ea7n t\u1ea7n s\u1ed1 cao (HF) ph\u1ea3n \u00e1nh ho\u1ea1t \u0111\u1ed9ng c\u1ee7a d\u00e2y ph\u1ebf v\u1ecb. Do \u0111\u00f3, t\u1ef7 l\u1ec7 LF\/HF l\u00e0 ch\u1ec9 s\u1ed1 d\u00f9ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 c\u00e2n b\u1eb1ng gi\u1eefa ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh giao c\u1ea3m v\u00e0 ph\u1ebf v\u1ecb.<\/p>\n\n\n\n<p>B\u1eb1ng c\u00e1ch quan s\u00e1t t\u00e1c \u0111\u1ed9ng \u0111i\u1ec7n sinh l\u00fd c\u1ee7a SSYX tr\u00ean tim l\u1ee3n mini Trung Qu\u1ed1c v\u00e0 t\u1ebf b\u00e0o c\u01a1 th\u1ea5t th\u1ecf Guinea c\u00f4 l\u1eadp, Feng v\u00e0 c\u1ed9ng s\u1ef1 cho th\u1ea5y SSYX c\u00f3 th\u1ec3 t\u0103ng nh\u1ecbp tim v\u00e0 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng d\u1eabn truy\u1ec1n c\u1ee7a tim. Khi h\u1ec7 th\u1ea7n kinh t\u1ef1 ch\u1ee7 b\u1ecb \u1ee9c ch\u1ebf th\u00ed nghi\u1ec7m, SSYX kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nh\u1ecbp tim n\u1ed9i t\u1ea1i.<\/p>\n\n\n\n<p>M\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c v\u1ec1 t\u00e1i c\u1ea5u tr\u00fac \u0111i\u1ec7n nh\u0129 v\u00e0 rung nh\u0129 c\u01a1n cho th\u1ea5y SSYX \u1ee9c ch\u1ebf t\u00e1i c\u1ea5u tr\u00fac \u0111i\u1ec7n nh\u0129 v\u00e0 kh\u1ea3 n\u0103ng m\u1eafc rung nh\u0129 sau 8 tu\u1ea7n gh\u00e9p nh\u1ecbp nh\u0129 gi\u00e1n \u0111o\u1ea1n k\u00e9o d\u00e0i \u1edf \u0111\u1ed9ng v\u1eadt th\u00ed nghi\u1ec7m, gi\u1ea3m LF v\u00e0 t\u1ef7 l\u1ec7 LF\/HF. T\u1ef7 l\u1ec7 LF\/HF, l\u00e0 ch\u1ec9 s\u1ed1 ph\u1ea3n \u00e1nh t\u01b0\u01a1ng t\u00e1c gi\u1eefa ho\u1ea1t \u0111\u1ed9ng giao c\u1ea3m v\u00e0 ph\u1ebf v\u1ecb, t\u0103ng sau khi gh\u00e9p nh\u1ecbp nh\u0129 gi\u00e1n \u0111o\u1ea1n l\u00e2u d\u00e0i, d\u1eabn \u0111\u1ebfn t\u0103ng ho\u1ea1t \u0111\u1ed9ng giao c\u1ea3m v\u00e0 gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng ph\u1ebf v\u1ecb. Do \u0111\u00f3, SSYX c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf t\u00e1i c\u1ea5u tr\u00fac giao c\u1ea3m trong qu\u00e1 tr\u00ecnh gh\u00e9p nh\u1ecbp nh\u0129 gi\u00e1n \u0111o\u1ea1n l\u00e2u d\u00e0i b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh t\u1ef1 ch\u1ee7.<\/p>\n\n\n\n<p>Ngo\u00e0i ra, nghi\u00ean c\u1ee9u tr\u00ean c\u0169ng ch\u1ec9 ra r\u1eb1ng kh\u00f4ng ch\u1ec9 TNF-\u03b1, m\u00e0 c\u00e1c cytokine vi\u00eam kh\u00e1c c\u0169ng b\u1ecb \u1ee9c ch\u1ebf khi k\u00edch th\u00edch d\u00e2y ph\u1ebf v\u1ecb ho\u1eb7c d\u00f9ng kh\u00e1ng th\u1ec3 \u03b17nAChR. \u0110\u01b0\u1eddng d\u1eabn ch\u1ed1ng vi\u00eam cholinergic \u1ee9c ch\u1ebf vi\u00eam th\u00f4ng qua k\u00edch ho\u1ea1t d\u00e2y ph\u1ebf v\u1ecb. \u0110\u1ed3ng th\u1eddi, SSYX \u1ee9c ch\u1ebf gi\u1ea3m Ach v\u00e0 bi\u1ec3u hi\u1ec7n protein \u03b17nAChR \u1edf nh\u0129, cho th\u1ea5y SSYX ch\u1ed1ng lo\u1ea1n nh\u1ecbp b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a m\u1ea5t c\u00e2n b\u1eb1ng ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh t\u1ef1 ch\u1ee7, t\u0103ng ho\u1ea1t \u0111\u1ed9ng d\u00e2y ph\u1ebf v\u1ecb, t\u1eeb \u0111\u00f3 t\u0103ng c\u01b0\u1eddng \u0111\u01b0\u1eddng d\u1eabn ch\u1ed1ng vi\u00eam cholinergic, gi\u1ea3m m\u1ee9c cytokine vi\u00eam v\u00e0 b\u1ea3o v\u1ec7 ch\u1ed1ng rung nh\u0129.<\/p>\n\n\n\n<p>Trong m\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c, khi SSYX \u0111\u01b0\u1ee3c d\u00f9ng sau th\u1eaft \u0111\u1ed9ng m\u1ea1ch v\u00e0nh \u1edf th\u1ecf New Zealand, c\u00f3 m\u1ed1i t\u01b0\u01a1ng quan \u0111\u00e1ng k\u1ec3 gi\u1eefa t\u00e1i c\u1ea5u tr\u00fac th\u1ea7n kinh t\u1ef1 ch\u1ee7 sau nh\u1ed3i m\u00e1u c\u01a1 tim v\u00e0 t\u1ef7 l\u1ec7 lo\u1ea1n nh\u1ecbp. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf c\u00e1c y\u1ebfu t\u1ed1 vi\u00eam v\u00e0 \u0111\u01b0\u1eddng t\u00edn hi\u1ec7u NGF, SSYX c\u00f3 th\u1ec3 gi\u1ea3m m\u1eadt \u0111\u1ed9 th\u1ea7n kinh \u1edf \u0111\u1ed9ng v\u1eadt th\u00ed nghi\u1ec7m sau nh\u1ed3i m\u00e1u c\u01a1 tim, g\u1ee3i \u00fd r\u1eb1ng can thi\u1ec7p v\u00e0o t\u00e1i c\u1ea5u tr\u00fac th\u1ea7n kinh t\u1ef1 ch\u1ee7 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t c\u00e1ch quan tr\u1ecdng \u0111\u1ec3 ph\u00f2ng ng\u1eeba lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>5.2.4. \u1ee8c ch\u1ebf vi\u00eam<\/p>\n\n\n\n<p>Trong t\u1ebf b\u00e0o c\u01a1 tim, ph\u1ea3n \u1ee9ng vi\u00eam do s\u1ef1 gi\u1ea3i ph\u00f3ng c\u00e1c y\u1ebfu t\u1ed1 vi\u00eam c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o c\u01a1 tim, th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn lo\u1ea1n nh\u1ecbp tim sau t\u1ed5n th\u01b0\u01a1ng nh\u1ed3i m\u00e1u \u2013 t\u00e1i t\u01b0\u1edbi m\u00e1u. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng vi\u00eam li\u00ean quan tr\u1ef1c ti\u1ebfp \u0111\u1ebfn s\u1ef1 kh\u1edfi ph\u00e1t rung nh\u0129, v\u00e0 c\u00e1c cytokine vi\u00eam nh\u01b0 TNF-\u03b1 v\u00e0 IL-6 c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn x\u01a1 h\u00f3a v\u00e0 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c ti\u1ec3u \u0111\u01a1n v\u1ecb k\u00eanh ion, trong \u0111\u00f3 bi\u1ec3u hi\u1ec7n b\u1ea5t th\u01b0\u1eddng c\u1ee7a c\u00e1c ti\u1ec3u \u0111\u01a1n v\u1ecb n\u00e0y \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn t\u00e1i c\u1ea5u tr\u00fac \u0111i\u1ec7n c\u1ee7a rung nh\u0129.<\/p>\n\n\n\n<p>Zhao v\u00e0 c\u1ed9ng s\u1ef1 ch\u1ee9ng minh r\u1eb1ng SSYX c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 t\u0103ng m\u1ee9c TNF-\u03b1 v\u00e0 IL-6 sau gh\u00e9p nh\u1ecbp nh\u0129 gi\u00e1n \u0111o\u1ea1n k\u00e9o d\u00e0i \u1edf ch\u00f3, \u0111\u1ed3ng th\u1eddi ng\u0103n gi\u1ea3m m\u1ee9c acetylcholine. Do \u0111\u00f3, h\u1ecd gi\u1ea3 thuy\u1ebft r\u1eb1ng t\u00e1c \u0111\u1ed9ng c\u1ee7a SSYX l\u00ean c\u00e1c cytokine vi\u00eam c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn t\u0103ng ho\u1ea1t \u0111\u1ed9ng d\u00e2y ph\u1ebf v\u1ecb.<\/p>\n\n\n\n<p>R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u1ed9i m\u00f4 l\u00e0 y\u1ebfu t\u1ed1 then ch\u1ed1t trong vi\u00eam m\u1ea1ch, \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng m\u1ed9t ph\u1ea7n b\u1edfi t\u0103ng bi\u1ec3u hi\u1ec7n c\u00e1c ph\u00e2n t\u1eed b\u00e1m d\u00ednh tr\u00ean b\u1ec1 m\u1eb7t n\u1ed9i m\u00f4. \u0110\u1ea1i th\u1ef1c b\u00e0o s\u1ea3n xu\u1ea5t c\u00e1c cytokine ti\u1ec1n vi\u00eam nh\u01b0 iNOS, TNF-\u03b1, MCP-1 v\u00e0 IL-1\u03b2, v\u00e0 s\u1ef1 k\u00edch ho\u1ea1t \u0111\u1ea1i th\u1ef1c b\u00e0o g\u00f3p ph\u1ea7n \u0111\u00e1ng k\u1ec3 v\u00e0o vi\u00eam do t\u1ed5n th\u01b0\u01a1ng n\u1ed9i m\u00f4. \u0110\u1ea1i th\u1ef1c b\u00e0o c\u01b0 tr\u00fa trong m\u00f4 tim c\u00f3 th\u1ec3 t\u0103ng d\u1eabn truy\u1ec1n \u0111i\u1ec7n b\u1eb1ng c\u00e1ch h\u00ecnh th\u00e0nh khe n\u1ed1i (gap junction) v\u1edbi t\u1ebf b\u00e0o c\u01a1 tim. Ph\u00e2n c\u1ef1c \u0111\u1ea1i th\u1ef1c b\u00e0o c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u1ea5u tr\u00fac khe n\u1ed1i c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim, d\u1eabn \u0111\u1ebfn lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>Zhang v\u00e0 c\u1ed9ng s\u1ef1 ph\u00e1t hi\u1ec7n r\u1eb1ng SSYX kh\u00f4ng ch\u1ec9 t\u0103ng bi\u1ec3u hi\u1ec7n protein v\u00e0 m\u1ee9c NO c\u1ee7a eNOS trong m\u00f4 tim c\u1ee7a chu\u1ed9t db\/db, m\u00e0 c\u00f2n gi\u1ea3m bi\u1ec3u hi\u1ec7n mRNA c\u1ee7a ET-1 v\u00e0 c\u1ea3i thi\u1ec7n tr\u1ef1c ti\u1ebfp ch\u1ee9c n\u0103ng n\u1ed9i m\u00f4 trong nghi\u00ean c\u1ee9u v\u1ec1 kh\u1ea3 n\u0103ng lo\u1ea1n nh\u1ecbp \u1edf chu\u1ed9t db\/db. T\u01b0\u01a1ng t\u1ef1, SSYX gi\u1ea3m x\u00e2m nh\u1eadp t\u1ebf b\u00e0o vi\u00eam trong m\u00f4 tim chu\u1ed9t, \u1ee9c ch\u1ebf bi\u1ec3u hi\u1ec7n mRNA c\u1ee7a c\u00e1c cytokine vi\u00eam TNF-\u03b1, IL-1\u03b2, IL-6, MCP-1 v\u00e0 CCR-2, c\u0169ng nh\u01b0 ph\u00e2n c\u1ef1c \u0111\u1ea1i th\u1ef1c b\u00e0o, t\u1eeb \u0111\u00f3 gi\u1ea3m kh\u1ea3 n\u0103ng lo\u1ea1n nh\u1ecbp \u1edf chu\u1ed9t db\/db. Do \u0111\u00f3, nghi\u00ean c\u1ee9u x\u00e1c nh\u1eadn t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 n\u1ed9i m\u00f4 c\u1ee7a SSYX \u1edf chu\u1ed9t db\/db.<\/p>\n\n\n\n<p>Ngo\u00e0i ra, c\u00e1c th\u00ed nghi\u1ec7m in vitro v\u00e0 nghi\u00ean c\u1ee9u \u0111i\u1ec7n sinh l\u00fd d\u01b0\u1edbi \u0111i\u1ec1u ki\u1ec7n t\u01b0\u1edbi m\u00e1u tim to\u00e0n ph\u1ea7n Langendorff cho th\u1ea5y r\u1eb1ng, tr\u00ean c\u01a1 s\u1edf c\u1ea3i thi\u1ec7n t\u00e1i c\u1ea5u tr\u00fac \u0111i\u1ec7n nh\u0129, SSYX gi\u1ea3m m\u1ee9c c\u00e1c ch\u1ec9 d\u1ea5u huy\u1ebft thanh c\u1ee7a t\u1ed5n th\u01b0\u01a1ng oxy h\u00f3a v\u00e0 t\u0103ng m\u1ee9c enzym ch\u1ed1ng oxy h\u00f3a SOD v\u00e0 GSH-Px trong huy\u1ebft thanh c\u1ee7a chu\u1ed9t ti\u1ec3u \u0111\u01b0\u1eddng. \u0110\u1ed3ng th\u1eddi, SSYX gi\u1ea3m m\u1ee9c c\u00e1c ch\u1ec9 d\u1ea5u vi\u00eam huy\u1ebft thanh TNF-\u03b1 v\u00e0 IL-6, t\u1eeb \u0111\u00f3 gi\u1ea3m x\u01a1 nh\u0129 do ti\u1ec3u \u0111\u01b0\u1eddng th\u00f4ng qua t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam v\u00e0 ch\u1ed1ng oxy h\u00f3a.<\/p>\n\n\n\n<p>H\u01a1n n\u1eefa, protein ph\u1ea3n \u1ee9ng C (CRP\/hs-CRP), TNF-\u03b1, IL-6 v\u00e0 IL-1\u03b2 l\u00e0 c\u00e1c y\u1ebfu t\u1ed1 \u0111\u1eb7c tr\u01b0ng c\u1ee7a ph\u1ea3n \u1ee9ng vi\u00eam to\u00e0n th\u00e2n, c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t t\u1ebf b\u00e0o vi\u00eam g\u00e2y thi\u1ebfu oxy v\u00e0 co m\u1ea1ch, \u0111\u1ed3ng th\u1eddi \u0111i\u1ec1u h\u00f2a ch\u1ee9c n\u0103ng tim m\u1ed9t c\u00e1ch \u0111\u1ed9c l\u1eadp. Ch\u00fang l\u00e0 ch\u1ec9 s\u1ed1 l\u00e2m s\u00e0ng quan tr\u1ecdng ph\u1ea3n \u00e1nh thay \u0111\u1ed5i vi\u00eam trong c\u00e1c b\u1ec7nh tim m\u1ea1ch nh\u01b0 b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch v\u00e0nh v\u00e0 lo\u1ea1n nh\u1ecbp.<\/p>\n\n\n\n<p>Nhi\u1ec1u nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng SSYX, \u0111\u1ed9c l\u1eadp ho\u1eb7c k\u1ebft h\u1ee3p v\u1edbi metoprolol v\u00e0 amiodarone, c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf hi\u1ec7u qu\u1ea3 bi\u1ec3u hi\u1ec7n c\u00e1c ch\u1ec9 d\u1ea5u vi\u00eam bao g\u1ed3m CRP (hs-CRP), TNF-\u03b1, IL-6 v\u00e0 IL-1\u03b2 \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch v\u00e0nh v\u00e0 lo\u1ea1n nh\u1ecbp, d\u1eabn \u0111\u1ebfn gi\u1ea3m vi\u00eam to\u00e0n th\u00e2n, ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng lo\u1ea1n nh\u1ecbp t\u1ed1t h\u01a1n v\u00e0 c\u1ea3i thi\u1ec7n k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng t\u1ed5ng th\u1ec3.<\/p>\n\n\n\n<p>5.2.5. C\u1ea3i thi\u1ec7n chuy\u1ec3n h\u00f3a n\u0103ng l\u01b0\u1ee3ng ty th\u1ec3<\/p>\n\n\n\n<p>Ty th\u1ec3 l\u00e0 n\u01a1i ch\u00ednh \u0111\u1ec3 s\u1ea3n xu\u1ea5t ATP th\u00f4ng qua chu tr\u00ecnh axit tricarboxylic. Ty th\u1ec3 c\u1ea7n li\u00ean t\u1ee5c t\u1ed5ng h\u1ee3p ATP \u0111\u1ec3 \u0111\u00e1p \u1ee9ng nhu c\u1ea7u n\u0103ng l\u01b0\u1ee3ng c\u1ee7a t\u1ebf b\u00e0o c\u01a1 tim, \u0111\u1ea3m b\u1ea3o ch\u1ee9c n\u0103ng co b\u00f3p tim th\u00edch h\u1ee3p v\u00e0 \u1ed5n \u0111\u1ecbnh ho\u1ea1t \u0111\u1ed9ng \u0111i\u1ec7n c\u1ee7a c\u01a1 tim. Khi ch\u1ee9c n\u0103ng ty th\u1ec3 b\u1ecb suy gi\u1ea3m, s\u1ea3n xu\u1ea5t ATP trong t\u1ebf b\u00e0o c\u01a1 tim kh\u00f4ng \u0111\u1ee7, l\u00e0m r\u1ed1i lo\u1ea1n c\u00e2n b\u1eb1ng ion v\u00e0 cu\u1ed1i c\u00f9ng d\u1eabn \u0111\u1ebfn lo\u1ea1n nh\u1ecbp tim.<\/p>\n\n\n\n<p>Qu\u00e1 tr\u00ecnh sinh t\u1ed5ng h\u1ee3p ATP c\u1ee7a ty th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a b\u1edfi m\u1ed9t h\u1ec7 th\u1ed1ng ph\u1ee9c t\u1ea1p bao g\u1ed3m nhi\u1ec1u b\u01b0\u1edbc, nh\u01b0 s\u1eed d\u1ee5ng c\u01a1 ch\u1ea5t glucose v\u00e0 acid b\u00e9o, phosphoryl h\u00f3a oxy h\u00f3a, v\u00e0 h\u00ecnh th\u00e0nh c\u0169ng nh\u01b0 v\u1eadn chuy\u1ec3n ATP ty th\u1ec3. Trong \u0111\u00f3, peroxisome proliferator-activated receptor gamma coactivator 1\u03b1 (PGC-1\u03b1) l\u00e0 y\u1ebfu t\u1ed1 \u0111i\u1ec1u h\u00f2a ch\u1ee7 ch\u1ed1t tham gia v\u00e0o sinh t\u1ed5ng h\u1ee3p ATP c\u1ee7a ty th\u1ec3 v\u00e0 chuy\u1ec3n h\u00f3a oxy h\u00f3a \u1edf tim. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u g\u1ee3i \u00fd r\u1eb1ng t\u0103ng m\u1ee9c PGC-1\u03b1 c\u00f3 th\u1ec3 t\u0103ng n\u1ed3ng \u0111\u1ed9 ATP v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng ty th\u1ec3.<\/p>\n\n\n\n<p>AMP-activated protein kinase (AMPK) \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a chuy\u1ec3n h\u00f3a lipid v\u00e0 c\u00e2n b\u1eb1ng n\u0103ng l\u01b0\u1ee3ng. Khi m\u1ee9c ATP gi\u1ea3m, AMPK \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t nhanh ch\u00f3ng \u0111\u1ec3 duy tr\u00ec c\u00e2n b\u1eb1ng n\u0103ng l\u01b0\u1ee3ng.<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng SSYX c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t AMPK v\u00e0 \u0111\u00e1ng k\u1ec3 t\u0103ng bi\u1ec3u hi\u1ec7n PGC-1\u03b1. \u0110\u1ed3ng th\u1eddi, SSYX c\u00f2n th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh oxy h\u00f3a acid b\u00e9o v\u00e0 glucose b\u1eb1ng c\u00e1ch t\u0103ng bi\u1ec3u hi\u1ec7n c\u00e1c y\u1ebfu t\u1ed1 quan tr\u1ecdng trong chuy\u1ec3n h\u00f3a c\u1ee7a ch\u00fang, c\u1ee5 th\u1ec3 l\u00e0 carnitine palmitoyltransferase-1 (CPT-1) v\u00e0 glucose transporter-4 (GLUT-4). K\u1ebft qu\u1ea3 l\u00e0 t\u0103ng c\u01b0\u1eddng phosphoryl h\u00f3a oxy h\u00f3a v\u00e0 c\u1ea3i thi\u1ec7n chuy\u1ec3n h\u00f3a n\u0103ng l\u01b0\u1ee3ng.<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u n\u00e0y cung c\u1ea5p m\u1ed9t h\u01b0\u1edbng ti\u1ebfp c\u1eadn m\u1edbi cho \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh chuy\u1ec3n h\u00f3a c\u01a1 tim trong t\u01b0\u01a1ng lai, ng\u1ee5 \u00fd r\u1eb1ng SSYX t\u0103ng kh\u1ea3 n\u0103ng phosphoryl h\u00f3a oxy h\u00f3a c\u1ee7a t\u1ebf b\u00e0o trong ph\u00ec \u0111\u1ea1i c\u01a1 tim, c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng tim, v\u00e0 l\u00e0m ch\u1eadm ho\u1eb7c th\u1eadm ch\u00ed \u0111\u1ea3o ng\u01b0\u1ee3c ti\u1ebfn tri\u1ec3n c\u1ee7a ph\u00ec \u0111\u1ea1i c\u01a1 tim d\u1eabn t\u1edbi suy tim. Nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y h\u1ed7 tr\u1ee3 ph\u00e1t tri\u1ec3n c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi cho ph\u00ec \u0111\u1ea1i c\u01a1 tim v\u00e0 suy tim.<\/p>\n\n\n\n<p>5.2.6. C\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng n\u1ed9i m\u1ea1c vi m\u1ea1ch v\u00e0 th\u00fac \u0111\u1ea9y h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u<\/p>\n\n\n\n<p>R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng vi m\u1ea1ch \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong t\u00e1i c\u1ea5u tr\u00fac th\u1ea5t tr\u00e1i sau nh\u1ed3i m\u00e1u c\u01a1 tim c\u1ea5p (AMI). T\u1eafc c\u1ea5p t\u00ednh \u0111\u1ed9ng m\u1ea1ch v\u00e0nh d\u1eabn \u0111\u1ebfn thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 t\u1ebf b\u00e0o c\u01a1 tim, g\u00e2y t\u1ed5n th\u01b0\u01a1ng vi m\u1ea1ch, ch\u1eb3ng h\u1ea1n nh\u01b0 t\u1ed5n th\u01b0\u01a1ng mao m\u1ea1ch v\u00e0 t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u c\u01a1 tim. \u0110i\u1ec1u n\u00e0y cu\u1ed1i c\u00f9ng c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ph\u00f9 n\u1ec1 v\u00e0 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u1ed9i m\u1ea1c vi m\u1ea1ch.<\/p>\n\n\n\n<p>N\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u l\u00e0 m\u1ed9t c\u01a1 quan n\u1ed9i ti\u1ebft v\u00e0 c\u1eadn ti\u1ebft quan tr\u1ecdng, tham gia v\u00e0o \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch v\u00e0 x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch. Nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng t\u1ed5n th\u01b0\u01a1ng n\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u l\u00e0 y\u1ebfu t\u1ed1 quan tr\u1ecdng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1eb9p l\u1ea1i m\u1ea1ch sau can thi\u1ec7p \u0111\u1ed9ng m\u1ea1ch v\u00e0nh qua da. C\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u \u0111i\u1ec1u h\u00f2a l\u01b0u l\u01b0\u1ee3ng m\u00e1u \u0111\u1ed9ng m\u1ea1ch v\u00e0nh th\u00f4ng qua vi\u1ec7c gi\u1ea3i ph\u00f3ng c\u00e1c y\u1ebfu t\u1ed1 t\u00e1c \u0111\u1ed9ng l\u00ean m\u1ea1ch m\u00e1u.<\/p>\n\n\n\n<p>Nitric oxide (NO) l\u00e0 ch\u1ea5t gi\u00e3n m\u1ea1ch ch\u00ednh do n\u1ed9i m\u1ea1c s\u1ea3n xu\u1ea5t.<br>Endothelin-1 (ET-1) l\u00e0 peptide n\u1ed9i sinh v\u1edbi t\u00e1c d\u1ee5ng co m\u1ea1ch m\u1ea1nh v\u00e0 k\u00e9o d\u00e0i tr\u00ean \u0111\u1ed9ng m\u1ea1ch v\u00e0nh.<\/p>\n\n\n\n<p>NO v\u00e0 ET-1 c\u00f3 m\u1ed1i li\u00ean h\u1ec7 ch\u1eb7t ch\u1ebd v\u1edbi ch\u1ee9c n\u0103ng n\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u. Khi ch\u1ee9c n\u0103ng n\u1ed9i m\u1ea1c b\u1ecb suy gi\u1ea3m, m\u1ee9c NO gi\u1ea3m \u0111\u00e1ng k\u1ec3, trong khi m\u1ee9c ET-1 t\u0103ng \u0111\u00e1ng k\u1ec3.<\/p>\n\n\n\n<p>Trong \u0111i\u1ec1u ki\u1ec7n sinh l\u00fd, t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c t\u1ed5ng h\u1ee3p von Willebrand factor (vWF), trung gian cho s\u1ef1 k\u1ebft d\u00ednh ti\u1ec3u c\u1ea7u v\u00e0o n\u1ed9i m\u1ea1c m\u1ea1ch b\u1ecb t\u1ed5n th\u01b0\u01a1ng. Tuy nhi\u00ean, trong \u0111i\u1ec1u ki\u1ec7n b\u1ec7nh l\u00fd, ti\u1ec3u c\u1ea7u \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t gi\u1ea3i ph\u00f3ng vWF, th\u00fac \u0111\u1ea9y k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u t\u1ea1i v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng m\u1ea1ch m\u00e1u, t\u1eeb \u0111\u00f3 khuy\u1ebfn kh\u00edch h\u00ecnh th\u00e0nh huy\u1ebft kh\u1ed1i.<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng SSYX c\u00f3 th\u1ec3 t\u0103ng m\u1eadt \u0111\u1ed9 vi m\u1ea1ch trong v\u00f9ng quanh nh\u1ed3i m\u00e1u \u1edf tim th\u1ecf, \u0111\u1ed3ng th\u1eddi gi\u1ea3m m\u1ee9c ET-1 v\u00e0 vWF v\u00e0 t\u0103ng m\u1ee9c NO trong huy\u1ebft t\u01b0\u01a1ng. R\u00f5 r\u00e0ng, SSYX c\u00f3 kh\u1ea3 n\u0103ng c\u1ea3i thi\u1ec7n vi tu\u1ea7n ho\u00e0n tim sau nh\u1ed3i m\u00e1u c\u01a1 tim, c\u01a1 ch\u1ebf c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn kh\u1ea3 n\u0103ng th\u00fac \u0111\u1ea9y h\u00ecnh th\u00e0nh mao m\u1ea1ch \u1edf v\u00f9ng ngo\u1ea1i vi nh\u1ed3i m\u00e1u v\u00e0 c\u00e2n b\u1eb1ng c\u00e1c y\u1ebfu t\u1ed1 gi\u00e3n m\u1ea1ch v\u00e0 co m\u1ea1ch do n\u1ed9i m\u1ea1c s\u1ea3n xu\u1ea5t.<\/p>\n\n\n\n<p>Ngo\u00e0i ra, Zhang v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng SSYX c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam sau \u0111\u00f3 th\u00f4ng qua \u0111\u01b0\u1eddng d\u1eabn eNOS, t\u1eeb \u0111\u00f3 gi\u1ea3m nguy c\u01a1 lo\u1ea1n nh\u1ecbp tim.<\/p>\n\n\n\n<p>C\u00e1c th\u00ed nghi\u1ec7m in vitro cho th\u1ea5y SSYX c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 kh\u1ea3 n\u0103ng s\u1ed1ng c\u00f2n c\u1ee7a t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c b\u1ecb t\u1ed5n th\u01b0\u01a1ng b\u1edfi m\u1ee9c glucose v\u00e0 lipid cao, \u0111\u1ed3ng th\u1eddi:<\/p>\n\n\n\n<p>Ng\u0103n gi\u1ea3m th\u1ebf m\u00e0ng ty th\u1ec3,<br>\u0110i\u1ec1u h\u00f2a ch\u1ee9c n\u0103ng h\u1ee3p nh\u1ea5t v\u00e0 ph\u00e2n t\u00e1ch ty th\u1ec3,<br>Gi\u1ea3m c\u0103ng th\u1eb3ng l\u01b0\u1edbi n\u1ed9i ch\u1ea5t,<br>Gi\u1ea3m ph\u1ea3n \u1ee9ng vi\u00eam,<br>\u1ee8c ch\u1ebf bi\u1ec3u hi\u1ec7n c\u00e1c ph\u00e2n t\u1eed k\u1ebft d\u00ednh.<\/p>\n\n\n\n<p>K\u1ebft qu\u1ea3 n\u00e0y x\u00e1c nh\u1eadn r\u1eb1ng SSYX c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c tr\u01b0\u1edbc t\u1ed5n th\u01b0\u01a1ng do glucose v\u00e0 lipid cao. \u0110i\u1ec1u n\u00e0y g\u1ee3i \u00fd r\u1eb1ng t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c vi m\u1ea1ch v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam \u0111i k\u00e8m l\u00e0m t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp tim. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf t\u1ed5n th\u01b0\u01a1ng n\u1ed9i m\u1ea1c v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam li\u00ean quan, SSYX c\u00f3 th\u1ec3 gi\u1ea3m t\u00ednh nh\u1ea1y c\u1ea3m v\u1edbi lo\u1ea1n nh\u1ecbp tim.<\/p>\n\n\n\n<p>Qu\u00e1 tr\u00ecnh t\u0103ng c\u01b0\u1eddng cung c\u1ea5p m\u00e1u cho c\u01a1 tim thi\u1ebfu m\u00e1u th\u00f4ng qua vi\u1ec7c th\u00fac \u0111\u1ea9y tu\u1ea7n ho\u00e0n b\u00e0ng h\u1ec7 b\u1eb1ng thu\u1ed1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 t\u1ea1o m\u1ea1ch tr\u1ecb li\u1ec7u (therapeutic angiogenesis). Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, li\u1ec7u ph\u00e1p n\u00e0y \u0111\u00e3 tr\u1edf n\u00ean ph\u1ed5 bi\u1ebfn trong \u0111i\u1ec1u tr\u1ecb l\u00e2m s\u00e0ng c\u00e1c b\u1ec7nh m\u1ea1ch m\u00e1u. T\u1ea1o m\u1ea1ch tr\u1ecb li\u1ec7u cho ph\u00e9p c\u01a1 tim thi\u1ebfu m\u00e1u gi\u1ea3i ph\u00f3ng m\u1ed9t lo\u1ea1t c\u00e1c y\u1ebfu t\u1ed1 th\u00fac \u0111\u1ea9y h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u, t\u1eeb \u0111\u00f3 k\u00edch th\u00edch s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c m\u1ea1ch m\u00e1u vi m\u00f4 m\u1edbi, thi\u1ebft l\u1eadp tu\u1ea7n ho\u00e0n b\u00e0ng h\u1ec7 c\u00f3 th\u1ec3 kh\u00f4i ph\u1ee5c l\u01b0u l\u01b0\u1ee3ng m\u00e1u t\u1edbi c\u01a1 tim thi\u1ebfu m\u00e1u v\u00e0 c\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng c\u0169ng nh\u01b0 ti\u00ean l\u01b0\u1ee3ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n<p>Y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng n\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u (VEGF), m\u1ed9t th\u00e0nh vi\u00ean c\u1ee7a h\u1ecd y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng ti\u1ec3u c\u1ea7u (platelet-derived growth factor), l\u00e0 m\u1ed9t ch\u1ea5t k\u00edch th\u00edch t\u0103ng sinh m\u1ea1nh m\u1ebd c\u1ee7a t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c, th\u00fac \u0111\u1ea9y h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u \u0111\u00e1ng k\u1ec3. Nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng SSYX th\u00fac \u0111\u1ea9y s\u1ef1 ph\u00e1t tri\u1ec3n m\u1ea1ch m\u00e1u tr\u00ean m\u00e0ng \u0111\u1ec7m chorioallantoic c\u1ee7a ph\u00f4i g\u00e0, d\u1eabn \u0111\u1ebfn t\u0103ng \u0111\u00e1ng k\u1ec3 t\u1ed5ng s\u1ed1 m\u1ea1ch m\u00e1u. Hi\u1ec7u qu\u1ea3 c\u1ee7a SSYX trong c\u01a1 ch\u1ebf n\u00e0y t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi VEGF. C\u00e1c nghi\u00ean c\u1ee9u in vitro c\u0169ng ch\u1ec9 ra r\u1eb1ng SSYX t\u0103ng c\u01b0\u1eddng s\u1ef1 sinh tr\u01b0\u1edfng c\u1ee7a t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c t\u0129nh m\u1ea1ch r\u1ed1n ng\u01b0\u1eddi, d\u1eabn \u0111\u1ebfn t\u0103ng s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o n\u1ed9i m\u1ea1c.<\/p>\n\n\n\n<p>Ngo\u00e0i c\u00e1c c\u01a1 ch\u1ebf \u0111\u00e3 n\u00eau, SSYX c\u00f2n \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong c\u00e1c h\u1ec7 th\u1ed1ng kh\u00e1c. Nghi\u00ean c\u1ee9u cho th\u1ea5y r\u1eb1ng s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa SSYX v\u00e0 simvastatin c\u00f3 th\u1ec3 gi\u1ea3m \u0111\u00e1ng k\u1ec3 cholesterol huy\u1ebft thanh v\u00e0 m\u1ee9c lipoprotein m\u1eadt \u0111\u1ed9 th\u1ea5p (LDL), t\u1eeb \u0111\u00f3 ng\u0103n ng\u1eeba c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch.<\/p>\n\n\n\n<p>V\u1ec1 ch\u1ee9c n\u0103ng mi\u1ec5n d\u1ecbch, c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng m\u1ee9c kh\u00e1ng th\u1ec3 t\u1ef1 \u0111\u1ed9ng ch\u1ed1ng th\u1ee5 th\u1ec3 \u03b21 (\u03b21-AAB) trong huy\u1ebft thanh t\u0103ng \u1edf b\u1ec7nh nh\u00e2n lo\u1ea1n nh\u1ecbp th\u1ea5t, c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn r\u1ed1i lo\u1ea1n mi\u1ec5n d\u1ecbch v\u00e0 s\u1ef1 t\u0103ng sinh t\u1ebf b\u00e0o T. Trong c\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a SSYX, t\u00f9ng, nh\u1ee5y hoa S\u01a1n Tra (Cornus officinalis), h\u1ea1t t\u00e1o ta v\u00e0 ng\u0169 v\u1ecb t\u1eed (Schisandra chinensis) c\u00f3 kh\u1ea3 n\u0103ng c\u1ea3i thi\u1ec7n m\u1ed9t ph\u1ea7n r\u1ed1i lo\u1ea1n mi\u1ec5n d\u1ecbch c\u1ee7a c\u01a1 th\u1ec3. Ngo\u00e0i ra, SSYX c\u00f2n c\u00f3 th\u1ec3 gi\u1ea3m m\u1ee9c \u03b21-AAB huy\u1ebft thanh \u1edf b\u1ec7nh nh\u00e2n lo\u1ea1n nh\u1ecbp th\u1ea5t v\u00e0 c\u1ea3i thi\u1ec7n ph\u00e2n b\u1ed1 c\u00e1c nh\u00f3m t\u1ebf b\u00e0o T, \u0111\u00e2y c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t trong nh\u1eefng c\u01a1 ch\u1ebf ch\u1ed1ng lo\u1ea1n nh\u1ecbp c\u1ee7a SSYX.<\/p>\n\n\n\n<p>B\u00ean c\u1ea1nh \u0111\u00f3, bi\u1ec3u hi\u1ec7n b\u1ea5t th\u01b0\u1eddng c\u1ee7a NR1 c\u00f3 th\u1ec3 l\u00e0 c\u01a1 ch\u1ebf ph\u00e2n t\u1eed quan tr\u1ecdng g\u00e2y tr\u1ea7m c\u1ea3m sau nh\u1ed3i m\u00e1u c\u01a1 tim, v\u00e0 SSYX c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n h\u00e0nh vi gi\u1ed1ng tr\u1ea7m c\u1ea3m \u1edf chu\u1ed9t sau nh\u1ed3i m\u00e1u th\u00f4ng qua \u0111i\u1ec1u h\u00f2a bi\u1ec3u hi\u1ec7n ti\u1ec3u \u0111\u01a1n v\u1ecb NR1.<\/p>\n\n\n\n<p>T\u00f3m l\u1ea1i, SSYX \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i v\u1ec1 c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp d\u1ef1a tr\u00ean l\u00fd lu\u1eadn c\u1ee7a Luobing. SSYX th\u1ec3 hi\u1ec7n \u01b0u th\u1ebf \u0111\u1eb7c bi\u1ec7t nh\u1edd kh\u1ea3 n\u0103ng ch\u1eb7n \u0111a k\u00eanh ion v\u00e0 \u0111i\u1ec1u h\u00f2a c\u00e1c k\u00eanh phi ion (H\u00ecnh 2 v\u00e0 B\u1ea3ng 2). Nh\u1eefng c\u01a1 ch\u1ebf n\u00e0y cung c\u1ea5p c\u01a1 s\u1edf \u0111i\u1ec7n sinh l\u00fd tim cho t\u00e1c d\u1ee5ng \u0111i\u1ec1u h\u00f2a hai chi\u1ec1u l\u00e2m s\u00e0ng, v\u1eeba \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp nhanh v\u1eeba \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp ch\u1eadm, l\u00e0m n\u1ed5i b\u1eadt \u01b0u \u0111i\u1ec3m c\u1ee7a \u201c\u0111i\u1ec1u h\u00f2a t\u1ed5ng h\u1ee3p\u201d trong can thi\u1ec7p khai th\u00f4ng tu\u1ea7n ho\u00e0n b\u00e0ng h\u1ec7. Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y \u0111\u1eb7t n\u1ec1n t\u1ea3ng cho hi\u1ec3u bi\u1ebft khoa h\u1ecdc v\u1ec1 chuy\u1ec3n \u0111\u1ed5i t\u1eeb ph\u01b0\u01a1ng ph\u00e1p \u201cch\u1ed1ng lo\u1ea1n nh\u1ecbp\u201d sang \u201c\u0111i\u1ec1u h\u00f2a lo\u1ea1n nh\u1ecbp\u201d, \u0111\u1ed3ng th\u1eddi cung c\u1ea5p c\u01a1 s\u1edf quan tr\u1ecdng cho nghi\u00ean c\u1ee9u ti\u1ebfp theo v\u1ec1 c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp nh\u1eb1m n\u00e2ng cao hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/cdn.ncbi.nlm.nih.gov\/pmc\/blobs\/ee89\/11367280\/1259014e23b9\/gr2.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<p>L\u00fd thuy\u1ebft d\u01b0\u1ee3c l\u00fd m\u1ea1ng<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Reference<\/th><th>Compound<\/th><th>Count<\/th><\/tr><\/thead><tbody><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib15\">15<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Dan-Shen<\/strong>: Tanshinone \u2161 A<br><strong>Huang-Lian<\/strong>: Berberine Hydrochloride<br><strong>Nan-Wu-Wei-Zi<\/strong>: Schisandrin A<br><strong>Shan-Zhu-Yu<\/strong>: Strychnine<\/td><td class=\"has-text-align-left\" data-align=\"left\">4<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib7\">7<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Ren-Shen<\/strong>: Ginsenoside Re; Ginsenoside Rg1<\/td><td class=\"has-text-align-left\" data-align=\"left\">2<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib8\">8<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Ren-Shen<\/strong>: Ginsenoside<\/td><td class=\"has-text-align-left\" data-align=\"left\">1<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib22\">22<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Nan-Wu-Wei-Zi<\/strong>: Schisandrin A; Schisantherin A<\/td><td class=\"has-text-align-left\" data-align=\"left\">2<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib16\">16<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Paeoniflorin<br><strong>Dan-Shen<\/strong>: Salvianolic acid B<br><strong>Huang-Lian<\/strong>: Berberine<br><strong>Shan-Zhu-Yu<\/strong>: Strychnine<\/td><td class=\"has-text-align-left\" data-align=\"left\">4<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib18\">18<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Dan-Shen<\/strong>: Cryptotanshinone; Dihydrotanshinone I; Tanshinone I; Tanshinone \u2161 A<\/td><td class=\"has-text-align-left\" data-align=\"left\">4<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib31\">31<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Dan-Shen<\/strong>: Protocatechualdehyde<\/td><td class=\"has-text-align-left\" data-align=\"left\">1<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib32\">32<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Ren-Shen<\/strong>: Ginsenoside Rb1<\/td><td class=\"has-text-align-left\" data-align=\"left\">1<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib13\">13<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Apigenin; Baicalin; Calyx isoflavone; Catechin; Ellagic acid; Kaempferol; Paeoniflorin; Paeoniflorin; Baicalin; Protocatechuic acid; Gallic acid<br><strong>Dan-Shen<\/strong>: Baicalin; Protocatechuic acid; Cryptotanshinone; Danshensu; Dihydrotanshinone \u2160; Hydroxyttanshinone \u2161 A; Rosemary acid; Salvia miltiorrhiza cryptospironolactone; Salvianolic acid A; Salvianolic acid B; Salvianolic acid C; Salvianolic acid D; Salvianolic acid F; Salviol A; Sodium danshensu; Tanshinone \u2160; Tanshinone \u2164; Rutin; Caffeic acid; Tanshinone \u2161 A; Protocatechualdehyde; Quercetin<br><strong>Gan-Song<\/strong>: Geranium lignin; Luteolin; Luteolin; Robinin; Caffeic acid; Tanshinone \u2161 A; Chlorogenic acid; Protocatechuic acid; Gallic acid<br><strong>Huang-Lian<\/strong>: Chlorogenic acid; Berberine; Coptisine; Corydine; Emodin; Ferulic acid; Jatrorrhizine\/Tetrandrine; Jatrorrhizine\/Tetrandrine; Magnolia alkaloid; Palmatine; Protocatechualdehyde; Betaine<br><strong>Nan-Wu-Wei-Zi<\/strong>: Hyperoside; Schisantherin A; Schisandrin A; Schisandrin B; Rutin<br><strong>Ren-Shen<\/strong>: Ginsenoside Re; Ginsenoside Rg1<br>Sang-Ji-Sheng: Quercetin<br><strong>Shan-Zhu-Yu<\/strong>: Betaine; Strychnine; Gallic acid<br><strong>Tu-Bie-Chong<\/strong>: 5,4 \u2032- dihydroxy-7-methoxyflavone<\/td><td class=\"has-text-align-left\" data-align=\"left\">54<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib19\">19<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Paeoniflorin*<br><strong>Nan-Wu-Wei-Zi<\/strong>: Schisandrin A*<br>Suan-Zao-Ren: Spinozol*<\/td><td class=\"has-text-align-left\" data-align=\"left\">3<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[33]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Paeoniflorin<br><strong>Dan-Shen<\/strong>: Salvianolic acid A; Salvianolic acid B<br><strong>Huang-Lian<\/strong>: Berberine hydrochloride; Palmatine chloride<br><strong>Nan-Wu-Wei-Zi<\/strong>: Schisandrin A<br><strong>Shan-Zhu-Yu<\/strong>: Strychnine<br>Suan-Zao-Ren: Spinozol<\/td><td class=\"has-text-align-left\" data-align=\"left\">8<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[34]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Ren-Shen<\/strong>: Ginsenoside Rb1<\/td><td class=\"has-text-align-left\" data-align=\"left\">1<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[35]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Shan-Zhu-Yu<\/strong>: Strychnine<\/td><td class=\"has-text-align-left\" data-align=\"left\">1<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[36]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Nan-Wu-Wei-Zi<\/strong>: Schisantherin A<\/td><td class=\"has-text-align-left\" data-align=\"left\">1<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[37]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Ren-Shen<\/strong>: Ginsenoside Rb1<\/td><td class=\"has-text-align-left\" data-align=\"left\">1<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[38]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Apigenin; Baicalin; Calycosin; Catechin; Ellagic acid; Kaempferol; Paeoniflorin; Paeoniflorin; Baicalin; Protocatechuic acid; Gallic acid<br><strong>Dan-Shen<\/strong>: Baicalin; Protocatechuic acid; Cryptotanshinone; Danshensu; Dihydrotanshinone I; Hydroxyttanshinone \u2161 A; Rosemary acid; Salvianolic acid A; Salvianolic acid C; Salvianolic acid D; Rutin; Caffeic acid; Tanshinone \u2161 A; Protocatechualdehyde; Quercetin<br><strong>Gan-Song<\/strong>: Protocatechuic acid; Gallic acid; Diosmetin; Luteolin; Robinin; Caffeic acid; Tanshinone \u2161 A; chlorogenic acid<br><strong>Huang-Lian<\/strong>: Chlorogenic acid; Berberine; Emodin; Magnolia alkaloid; Palmatine; Violadine; Protocatechualdehyde; Betaine<br><strong>Nan-Wu-Wei-Zi<\/strong>: Hyperoside; Schisandrin A; Schisandrin B<br><strong>Sang-Ji-Sheng<\/strong>: Ferulic acid; Quercetin<br><strong>Shan-Zhu-Yu<\/strong>: Betaine; Gallic acid; Strychnine<\/td><td class=\"has-text-align-left\" data-align=\"left\">39<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[10]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Calycosin; Paeoniflorin<br><strong>Dan-Shen<\/strong>: Quercetin<br><strong>Gan-Song<\/strong>: Chlorogenic acid<br><strong>Sang-Ji-Sheng<\/strong>: Ferulic acid<\/td><td class=\"has-text-align-left\" data-align=\"left\">5<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[39]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Nan-Wu-Wei-Zi<\/strong>: Schisantherin A<br><strong>Shan-Zhu-Yu<\/strong>: Strychnine<\/td><td class=\"has-text-align-left\" data-align=\"left\">2<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[12]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Paeoniflorin<br><strong>Dan-Shen<\/strong>: Salvianolic acid B; Tanshinone \u2160; Tanshinone \u2161 A<br><strong>Nan-Wu-Wei-Zi<\/strong>: Schisandrin A; Schisantherin A<br><strong>Shan-Zhu-Yu<\/strong>: Strychnine; Morroniside<\/td><td class=\"has-text-align-left\" data-align=\"left\">8<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[40]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Paeoniflorin#; Huang-Lian: Berberine#; Coptisine#; Epiberberine#; Palmatine#;&nbsp;<strong>Nan-Wu-Wei-Zi<\/strong>: Deoxyschizandrin#; Schisantherin#; Shan-<strong>Zhu-Yu<\/strong>: Loganin#; Morroniside#;&nbsp;<strong>Suan-Zao-Ren<\/strong>: Spinosin#<\/td><td class=\"has-text-align-left\" data-align=\"left\">10<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[41]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Benzoylpaeoniflorin; Galloylpaeoniflorin; Paeoniflorin<br><strong>Dan-Shen<\/strong>: Cryptotanshinone; Danshensu; Dihydroisotanshine; Ginsenoside Re; Lithospermic acid; Protocatechualdehyde; Protocatechuic acid; Rosmarinic acid; Salvianolic acid A; Salvianolic acid B; Salvianolic acid C; Salvianolic acid D; Salvianolic acid E; Salvianolic acid H\/I; Salvianolic acid H\/I; Tanshinone I; Tanshinone IIA; Tanshinone IIB<br><strong>Gan-Song<\/strong>: 7-Deoxyloganic acid; Kanshone F; Linarin; M14; M16; Nardoaristolone B; Nardosinone<br><strong>Huang-Lian<\/strong>: 13-Hydroberberine; 13-Hydroxyberberastine; 13-Hydroxypalmatine; 13-Methylberberine; 13-Methylepiberberine; Berberastine; Berberine; Berberrubine; Columbamine; Coptisine; Dehydrocorydaline; Demethyleneberberine; Demethyleneepiberberine; Epiberberine; Jatrorrhizine; M15; M27; M32; M9; Palmatine; Worenine<br><strong>Mai-Dong<\/strong>: M89; Ophiopogonin B; Ophiopogonin D<br><strong>Nan-Wu-Wei-Zi<\/strong>: (?)-Anwulignan; Deoxyschizandrin; Epigomisin O; Gomisin G; Gomisin J; Pregomisin; Schisandrol A; Schisandrol B; Schisanhenol; Schisantherin A; Schisantherin B\/C; Schisantherin B\/C; Schisantherin D; Schizandrin B<br><strong>Ren-Shen<\/strong>: 20(R)-ginsenoside Rh1; 20(S)-ginsenoside Rh1; 20R-ginsenoside Rg2; 20R-ginsenoside Rg3; 20S-ginsenoside Rg2; 20S-ginsenoside Rg3; Ginsenoside F1; Ginsenoside F5; Ginsenoside Rb1; Ginsenoside Rb2; Ginsenoside Rc; Ginsenoside Rd; Ginsenoside Rf; Ginsenoside Rg1; Ginsenoside Rh4; Ginsenoside Ro; Notoginsenoside R1<br><strong>Sang-Ji-Sheng<\/strong>: Avicularin; Ferulic acid; Quercetin<br><strong>Shan-Zhu-Yu<\/strong>: Cornuside I; Loganin; Morroniside; Oleanic acid; Sweroside; Ursolic acid<br><strong>Suan-Zao-Ren<\/strong>: Jujuboside A; Jujuboside B; Spinosin<br><strong>TBD<\/strong>: Chlorogenic acid; Gallic acid; Loganic acid; Neochlorogenic acid<\/td><td class=\"has-text-align-left\" data-align=\"left\">99<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">[<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11367280\/#bib42\">42<\/a>]<\/td><td class=\"has-text-align-left\" data-align=\"left\"><strong>Chi-Shao<\/strong>: Paeoniflorin<sup>\u25b3<\/sup><br><strong>Dan-Shen<\/strong>: 3-Hydroxytanshinone IIB<sup>\u25b3<\/sup>; Cryptotanshinone<sup>\u25b3<\/sup>; Dihydrotanshinone I<sup>\u25b3<\/sup>; Methyl tanshinonate<sup>\u25b3<\/sup>; Neocryptotanshinone<sup>\u25b3<\/sup>; Protocatechuic aldehyde<sup>\u25b3<\/sup>; Tanshinol B<sup>\u25b3<\/sup>; Tanshinone I<sup>\u25b3<\/sup>; Tanshinone V<sup>\u25b3<\/sup>; Tashinone IIA<sup>\u25b3<\/sup><br><strong>Gan-Song<\/strong>: 7-deoxonarchinol A<sup>\u25b3<\/sup>; Aristolone<sup>\u25b3<\/sup>; Kanshone H<sup>\u25b3<\/sup>; Nardosinonedio<sup>\u25b3<\/sup>l; Nardostachone<sup>\u25b3<\/sup><br><strong>Huang-Lian<\/strong>: Berberine<sup>\u25b3<\/sup>; Palmatine<sup>\u25b3<\/sup><br><strong>Nan-Wu-Wei-Zi<\/strong>: Angeloylgomisin O<sup>\u25b3<\/sup>; Angeloylgomisin P<sup>\u25b3<\/sup>; Benzoylgomisin O<sup>\u25b3<\/sup>; Deoxyschisandrin<sup>\u25b3<\/sup>; Kadsuric acid<sup>\u25b3<\/sup>; Nigranoic acid<sup>\u25b3<\/sup>; Schisandrin<sup>\u25b3<\/sup>; Schisandrol B<sup>\u25b3<\/sup>; Schisandronic acid<sup>\u25b3<\/sup>; Schisanhenol<sup>\u25b3<\/sup>; Schisantherin A<sup>\u25b3<\/sup>; Schisantherin B<sup>\u25b3<\/sup>; Schisantherin C<sup>\u25b3<\/sup>; Schisantherin D<sup>\u25b3<\/sup>; Tigloylgomisin O<sup>\u25b3<\/sup>; Tigloylgomisin P<sup>\u25b3<\/sup><br><strong>Ren-Shen<\/strong>: Ginsenoside Rb1<sup>\u25b3<\/sup>; Ginsenoside Rb2<sup>\u25b3<\/sup>; Ginsenoside Rc<sup>\u25b3<\/sup><br><strong>Sang-Ji-Sheng<\/strong>: Quercitrin<sup>\u25b3<\/sup><br><strong>Shan-Zhu-Yu<\/strong>: 7-O-ethylmorroniside<sup>\u25b3<\/sup>; Loganin<sup>\u25b3<\/sup>; Morroniside; Sweroside<sup>\u25b3<\/sup><br><strong>Suan-Zao-Ren<\/strong>: Ceanothic acid<sup>\u25b3<\/sup>; Epiceanothic acid<sup>\u25b3<\/sup>; Magnoflorine<sup>\u25b3<\/sup><br><strong>TBD<\/strong>: 19-Hydroxyschisantherin B<sup>\u25b2<\/sup>; 19-Hydroxyschisantherin C<sup>\u25b2<\/sup>; 21-Hydroxyschisantherin B<sup>\u25b2<\/sup>; 21-Hydroxyschisantherin C<sup>\u25b2<\/sup>; 25, 26-Dihydroschisandronic acid\u2013O-gluA<sup>\u25b2<\/sup>; 3-Hydroxyschisandronic acid-O-gluA<sup>\u25b2<\/sup>; Cryptotanshinone catechol glucuronide<sup>\u25b2<\/sup>; Cryptotanshinone catechol glucuronide isomer<sup>\u25b2<\/sup>; Dehydrocryptotanshinone<sup>\u25b2<\/sup>; Dehydroneocryptotanshinone<sup>\u25b2<\/sup>; Dehydrotanshinone V<sup>\u25b2<\/sup>; Demethylated dihydroangeloylgomisin O<sup>\u25b2<\/sup>; Demethylated dihydroangeloylgomisin P<sup>\u25b2<\/sup>; Demethylated dihydroschisantherin A<sup>\u25b2<\/sup>; Demethylated dihydroschisantherin B<sup>\u25b2<\/sup>; Demethylated dihydroschisantherin C<sup>\u25b2<\/sup>; Demethylated dihydrotigloylgomisin O<sup>\u25b2<\/sup>; Demethylated dihydrotigloylgomisin P<sup>\u25b2<\/sup>; Demethylated hydroxytanshinone V<sup>\u25b2<\/sup>; Demethylated schisandrin-O-glucuronide<sup>\u25b2<\/sup>; Demethyleneberberine-2-O-glucuronide<sup>\u25b2<\/sup>; Demethylpalmatine-O-glucuronide<sup>\u25b2<\/sup>; Demethylpalmatine-O-glucuronide isomer<sup>\u25b2<\/sup>; Demethylschisandrin-O-glucuronide isomer I<sup>\u25b2<\/sup>; Demethylschisandrin-O-glucuronide isomer II<sup>\u25b2<\/sup>; Demethylthalifendine-10-O-glucuronide<sup>\u25b2<\/sup>; Didehydrotanshinone V<sup>\u25b2<\/sup>; Dihydrotanshinone I catechol glucuronide<sup>\u25b2<\/sup>; Hydrated and Decarbonylated of Dihydrotanshinone I<sup>\u25b2<\/sup>; Hydrated demethylneocryptotanshinone<sup>\u25b2<\/sup>; Hydroxyschisanhenol<sup>\u25b2<\/sup>; Hydroxyschisanhenol isomer I<sup>\u25b2<\/sup>; Hydroxyschisanhenol isomer II<sup>\u25b2<\/sup>; Kadsuric acid O-glucuronide<sup>\u25b2<\/sup>; Methyltanshinone V<sup>\u25b2<\/sup>; Neocryptotanshinone-O-glucuronide<sup>\u25b2<\/sup>; Nigranoic acid-O-glucuronide<sup>\u25b2<\/sup>; Schisandronic acid-27-O-glucuronide<sup>\u25b2<\/sup>; Schisanhenol-O-glucuronide<sup>\u25b2<\/sup>; Schisanhenol-O-glucuronide isomer<sup>\u25b2<\/sup>; Tanshinone I catechol glucuronide<sup>\u25b2<\/sup>; Tanshinone I catechol glucuronide isomer<sup>\u25b2<\/sup>; Tanshinone IIA catechol glucuronide<sup>\u25b2<\/sup>; Tanshinone IIA catechol glucuronide isomer<sup>\u25b2<\/sup>; Tanshinone V\u2013O-glucuronide<sup>\u25b2<\/sup>; Thalifendine<sup>\u25b2<\/sup>; Thalifendine-10-O-glucuronide<sup>\u25b2<\/sup><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">7. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng c\u1ee7a vi\u00ean nang Shensong Yangxin<\/h3>\n\n\n\n<p>Ch\u00fang t\u00f4i \u0111\u00e3 ti\u1ebfn h\u00e0nh t\u00ecm ki\u1ebfm tr\u00ean c\u00e1c c\u01a1 s\u1edf d\u1eef li\u1ec7u bao g\u1ed3m PubMed, C\u01a1 s\u1edf d\u1eef li\u1ec7u to\u00e0n v\u0103n t\u1ea1p ch\u00ed Trung Qu\u1ed1c (CNKI), C\u01a1 s\u1edf d\u1eef li\u1ec7u Wanfang, C\u01a1 s\u1edf d\u1eef li\u1ec7u t\u1ea1p ch\u00ed khoa h\u1ecdc v\u00e0 c\u00f4ng ngh\u1ec7 Trung Qu\u1ed1c VIP (ng\u00e0y t\u00ecm ki\u1ebfm: th\u00e1ng 5 n\u0103m 2023), c\u0169ng nh\u01b0 c\u00e1c c\u01a1 s\u1edf d\u1eef li\u1ec7u ti\u1ebfng Trung v\u00e0 ti\u1ebfng Anh kh\u00e1c. Trong c\u00e1c t\u00ecm ki\u1ebfm b\u1eb1ng ti\u1ebfng Trung, ch\u00fang t\u00f4i s\u1eed d\u1ee5ng c\u00e1c t\u1eeb kh\u00f3a nh\u01b0 \u201cShensong Yangxin capsule\u201d, \u201cr\u1ed1i lo\u1ea1n nh\u1ecbp tim\u201d, \u201cc\u01a1 ch\u1ebf\u201d, \u201chi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng\u201d, v.v. Trong ti\u1ebfng Anh, ch\u00fang t\u00f4i s\u1eed d\u1ee5ng c\u00e1c t\u1eeb kh\u00f3a nh\u01b0 \u201cShensong Yangxin capsule\u201d, \u201cSSYX\u201d, \u201ccurative effect\u201d, \u201cmechanism\u201d. Ch\u00fang t\u00f4i k\u1ebft h\u1ee3p c\u00e1c t\u1eeb ch\u1ee7 \u0111\u1ec1 v\u1edbi t\u1eeb t\u1ef1 do trong c\u00e1c t\u00ecm ki\u1ebfm n\u00e0y.<\/p>\n\n\n\n<p>T\u1ed5ng c\u1ed9ng, ch\u00fang t\u00f4i \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c 1.646 b\u00e0i b\u00e1o nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng, trong \u0111\u00f3 1.591 b\u00e0i li\u00ean quan \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp tim, bao g\u1ed3m c\u00e1c r\u1ed1i lo\u1ea1n nh\u1ecbp nhanh nh\u01b0 ngo\u1ea1i t\u00e2m thu th\u1ea5t, rung nh\u0129, nh\u1ecbp nhanh tr\u00ean th\u1ea5t, nh\u1ecbp ch\u1eadm xoang, h\u1ed9i ch\u1ee9ng n\u00fat xoang, block nh\u0129 th\u1ea5t, v\u00e0 c\u00e1c lo\u1ea1i kh\u00e1c. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u thu th\u1eadp c\u0169ng xem x\u00e9t r\u1ed1i lo\u1ea1n nh\u1ecbp tim \u0111i k\u00e8m v\u1edbi c\u00e1c t\u00ecnh tr\u1ea1ng nh\u01b0 b\u1ec7nh m\u1ea1ch v\u00e0nh, suy tim, vi\u00eam c\u01a1 tim v\u00e0 b\u1ec7nh van tim.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">7.1. Hi\u1ec7u qu\u1ea3 \u201ct\u1ed1c \u2013 tr\u1ea7m\u201d c\u1ee7a vi\u00ean nang Shensong Yangxin trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp tim<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">7.1.1. Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng c\u1ee7a vi\u00ean nang Shensong Yangxin tr\u00ean r\u1ed1i lo\u1ea1n nh\u1ecbp nhanh<\/h4>\n\n\n\n<p>R\u1ed1i lo\u1ea1n nh\u1ecbp nhanh (tachyarrhythmia) l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 \u0111\u1ed9c l\u1eadp \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ti\u00ean l\u01b0\u1ee3ng c\u1ee7a b\u1ec7nh tim m\u1ea1ch (CVD), \u0111\u1ed3ng th\u1eddi c\u0169ng l\u00e0 m\u1ed9t trong nh\u1eefng bi\u1ebfn ch\u1ee9ng ph\u1ed5 bi\u1ebfn c\u1ee7a CVD, bao g\u1ed3m ngo\u1ea1i t\u00e2m thu, nh\u1ecbp nhanh th\u1ea5t, rung nh\u0129, nh\u1ecbp nhanh tr\u00ean th\u1ea5t k\u1ecbch ph\u00e1t, cu\u1ed3ng nh\u0129, v.v. Nguy\u00ean nh\u00e2n c\u1ee7a r\u1ed1i lo\u1ea1n nh\u1ecbp nhanh c\u00f3 li\u00ean quan m\u1eadt thi\u1ebft \u0111\u1ebfn b\u1ea5t th\u01b0\u1eddng \u0111i\u1ec7n sinh l\u00fd c\u01a1 tim. Hi\u1ec7n nay, \u0111i\u1ec1u tr\u1ecb ch\u00ednh cho r\u1ed1i lo\u1ea1n nh\u1ecbp nhanh l\u00e0 d\u00f9ng thu\u1ed1c; tuy nhi\u00ean, h\u1ea7u h\u1ebft c\u00e1c thu\u1ed1c ch\u1ed1ng r\u1ed1i lo\u1ea1n nh\u1ecbp tim \u0111\u1ec1u g\u00e2y t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 nh\u1ecbp ch\u1eadm xoang sau khi d\u00f9ng l\u00e2u d\u00e0i, \u0111i\u1ec1u n\u00e0y gi\u1edbi h\u1ea1n ph\u1ea7n n\u00e0o \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng c\u1ee7a ch\u00fang. Do \u0111\u00f3, vi\u1ec7c ph\u00e1t tri\u1ec3n m\u1ed9t lo\u1ea1i thu\u1ed1c ch\u1ed1ng r\u1ed1i lo\u1ea1n nh\u1ecbp nhanh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 gi\u1ea3m tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng v\u00e0 n\u00e2ng cao ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n<p>Vi\u00ean nang Shensong Yangxin (SSYX) th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i t\u00e2m thu th\u1ea5t v\u00e0 c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng h\u1ed3i h\u1ed9p do ngo\u1ea1i t\u00e2m thu g\u00e2y ra. Khi k\u1ebft h\u1ee3p SSYX v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c, li\u1ec7u ph\u00e1p n\u00e0y th\u1ec3 hi\u1ec7n hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb r\u00f5 r\u1ec7t \u0111\u1ed1i v\u1edbi r\u1ed1i lo\u1ea1n nh\u1ecbp nhanh li\u00ean quan \u0111\u1ebfn nhi\u1ec1u t\u00ecnh tr\u1ea1ng, bao g\u1ed3m t\u0103ng huy\u1ebft \u00e1p, b\u1ec7nh m\u1ea1ch v\u00e0nh v\u00e0 suy tim. H\u01a1n n\u1eefa, SSYX \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0 an to\u00e0n khi s\u1eed d\u1ee5ng l\u00e2m s\u00e0ng. Hi\u1ec7n nay, c\u00e1c h\u01b0\u1edbng d\u1eabn li\u00ean quan khuy\u1ebfn ngh\u1ecb s\u1eed d\u1ee5ng SSYX trong \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i t\u00e2m thu th\u1ea5t.<\/p>\n\n\n\n<p>Trong m\u1ed9t nghi\u00ean c\u1ee9u c\u1ee7a Cao v\u00e0 c\u1ed9ng s\u1ef1, m\u1ed9t th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, \u0111a trung t\u00e2m, c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh t\u1ea1i 22 b\u1ec7nh vi\u1ec7n \u1edf Trung Qu\u1ed1c. Nghi\u00ean c\u1ee9u bao g\u1ed3m 859 b\u1ec7nh nh\u00e2n c\u00f3 ngo\u1ea1i t\u00e2m thu th\u1ea5t th\u01b0\u1eddng xuy\u00ean nh\u01b0ng ch\u1ee9c n\u0103ng tim b\u00ecnh th\u01b0\u1eddng, \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean v\u00e0o nh\u00f3m tim kh\u00f4ng h\u1eefu c\u01a1 ho\u1eb7c nh\u00f3m tim h\u1eefu c\u01a1 (r\u1ed1i lo\u1ea1n nh\u1ecbp th\u1ea5t k\u00e8m t\u0103ng huy\u1ebft \u00e1p, b\u1ec7nh m\u1ea1ch v\u00e0nh v\u00e0 c\u00e1c b\u1ec7nh li\u00ean quan kh\u00e1c). Sau 8 tu\u1ea7n can thi\u1ec7p v\u1edbi SSYX, gi\u1ea3 d\u01b0\u1ee3c v\u00e0 mexiletine, \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 Holter 24 gi\u1edd \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 theo d\u00f5i v\u00e0 t\u00ednh to\u00e1n s\u1ed1 l\u01b0\u1ee3ng ngo\u1ea1i t\u00e2m thu th\u1ea5t l\u00e0m ch\u1ec9 s\u1ed1 \u0111\u00e1nh gi\u00e1 ch\u00ednh. C\u00e1c ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 th\u1ee9 c\u1ea5p bao g\u1ed3m c\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng li\u00ean quan \u0111\u1ebfn ngo\u1ea1i t\u00e2m thu th\u1ea5t v\u00e0 \u0111\u00e1nh gi\u00e1 an to\u00e0n c\u1ee7a SSYX.<\/p>\n\n\n\n<p>K\u1ebft qu\u1ea3 cho th\u1ea5y, \u1edf nh\u00f3m tim kh\u00f4ng h\u1eefu c\u01a1, t\u1ef7 l\u1ec7 hi\u1ec7u qu\u1ea3 t\u1ed5ng th\u1ec3 c\u1ee7a SSYX v\u00e0 gi\u1ea3 d\u01b0\u1ee3c trong \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i t\u00e2m thu th\u1ea5t l\u1ea7n l\u01b0\u1ee3t l\u00e0 74,2 % v\u00e0 28,9 %. So v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c, SSYX l\u00e0m gi\u1ea3m r\u00f5 r\u1ec7t c\u00e1c tri\u1ec7u ch\u1ee9ng li\u00ean quan \u0111\u1ebfn ngo\u1ea1i t\u00e2m thu th\u1ea5t nh\u01b0 h\u1ed3i h\u1ed9p, kh\u00f3 th\u1edf, m\u1ea5t ng\u1ee7, m\u1ec7t m\u1ecfi v\u00e0 \u0111\u1ed5 m\u1ed3 h\u00f4i ban \u0111\u00eam. \u0110\u1ed1i v\u1edbi nh\u00f3m tim h\u1eefu c\u01a1, t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng t\u1ed5ng th\u1ec3 trong \u0111i\u1ec1u tr\u1ecb nh\u1ecbp nhanh th\u1ea5t l\u00e0 65,8 % v\u1edbi SSYX v\u00e0 50,7 % v\u1edbi mexiletine. Ngo\u00e0i ra, SSYX c\u0169ng hi\u1ec7u qu\u1ea3 trong gi\u1ea3m t\u1ea7n su\u1ea5t v\u00e0 tri\u1ec7u ch\u1ee9ng nh\u1ecbp nhanh tr\u00ean th\u1ea5t \u1edf b\u1ec7nh nh\u00e2n, b\u1ea5t k\u1ec3 c\u00f3 b\u1ec7nh tim h\u1eefu c\u01a1 hay kh\u00f4ng. R\u00f5 r\u00e0ng, SSYX c\u00f3 t\u00e1c d\u1ee5ng \u0111\u00e1ng k\u1ec3 tr\u00ean r\u1ed1i lo\u1ea1n nh\u1ecbp nhanh v\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng li\u00ean quan nh\u01b0 ngo\u1ea1i t\u00e2m thu th\u1ea5t, nh\u1ecbp nhanh th\u1ea5t v\u00e0 nh\u1ecbp nhanh tr\u00ean th\u1ea5t.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">7.1.2. Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng c\u1ee7a vi\u00ean nang Shensong Yangxin tr\u00ean nh\u1ecbp ch\u1eadm<\/h4>\n\n\n\n<p>R\u1ed1i lo\u1ea1n nh\u1ecbp tim m\u1ea1n t\u00ednh l\u00e0 m\u1ed9t b\u1ec7nh tim m\u1ea1ch \u0111\u1eb7c tr\u01b0ng b\u1edfi nh\u1ecbp tim ch\u1eadm do r\u1ed1i lo\u1ea1n d\u1eabn truy\u1ec1n c\u01a1 tim ho\u1eb7c suy gi\u1ea3m th\u1ea7n kinh t\u1ef1 ch\u1ee7 b\u1edfi nhi\u1ec1u nguy\u00ean nh\u00e2n kh\u00e1c nhau. Trong l\u00e2m s\u00e0ng, t\u1ed1c \u0111\u1ed9 th\u1ea5t d\u01b0\u1edbi 60 nh\u1ecbp\/ph\u00fat \u0111\u01b0\u1ee3c coi l\u00e0 ti\u00eau chu\u1ea9n, bao g\u1ed3m nh\u1ecbp ch\u1eadm xoang, block tim, h\u1ed9i ch\u1ee9ng n\u00fat xoang, v\u00e0 c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c. B\u1ec7nh th\u01b0\u1eddng \u0111i k\u00e8m v\u1edbi c\u00e1c b\u1ec7nh tim h\u1eefu c\u01a1 nh\u01b0 b\u1ec7nh m\u1ea1ch v\u00e0nh v\u00e0 suy tim m\u1ea1n t\u00ednh, \u0111\u1ed3ng th\u1eddi ch\u1ecbu \u1ea3nh h\u01b0\u1edfng c\u1ee7a c\u00e1c b\u1ec7nh l\u00fd k\u00e8m theo n\u00e0y. Hi\u1ec7n nay, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u00ednh trong y h\u1ecdc hi\u1ec7n \u0111\u1ea1i l\u00e0 s\u1eed d\u1ee5ng thu\u1ed1c kh\u00e1ng cholinergic, \u0111\u1eb7t m\u00e1y t\u1ea1o nh\u1ecbp v\u00e0 ph\u00e1 h\u1ee7y th\u1ea7n kinh tim, v\u00e0 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 th\u00e0nh c\u00f4ng l\u00e2m s\u00e0ng. Tuy nhi\u00ean, \u0111i\u1ec1u tr\u1ecb hi\u1ec7n nay c\u00f2n thi\u1ebfu t\u00ednh \u0111\u1eb7c hi\u1ec7u, v\u00e0 d\u00f9ng thu\u1ed1c T\u00e2y \u0111\u01b0\u1eddng u\u1ed1ng cho r\u1ed1i lo\u1ea1n nh\u1ecbp tim th\u01b0\u1eddng k\u00e8m nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5. Ngo\u00e0i ra, ch\u1ec9 \u0111\u1ecbnh ph\u1eabu thu\u1eadt cho nh\u1ecbp ch\u1eadm t\u01b0\u01a1ng \u0111\u1ed1i nghi\u00eam ng\u1eb7t, bi\u1ebfn ch\u1ee9ng sau m\u1ed5 th\u01b0\u1eddng n\u1eb7ng h\u01a1n, kh\u00f4ng thu\u1eadn l\u1ee3i cho nh\u00f3m b\u1ec7nh nh\u00e2n c\u00f3 nhi\u1ec1u b\u1ec7nh n\u1ec1n. Do \u0111\u00f3, t\u1ef7 l\u1ec7 ch\u1ea5p nh\u1eadn ph\u1eabu thu\u1eadt nh\u1ecbp ch\u1eadm c\u1ee7a b\u1ec7nh nh\u00e2n th\u1ea5p.<\/p>\n\n\n\n<p>\u0110\u1ec3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n c\u1ee7a SSYX trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp tim m\u1ea1n t\u00ednh, Pu v\u00e0 c\u1ed9ng s\u1ef1 ti\u1ebfn h\u00e0nh m\u1ed9t nghi\u00ean c\u1ee9u ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, \u0111a trung t\u00e2m, c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c t\u1ea1i 11 b\u1ec7nh vi\u1ec7n \u1edf Trung Qu\u1ed1c. H\u1ecd ph\u00e2n ng\u1eabu nhi\u00ean 219 b\u1ec7nh nh\u00e2n nh\u1ecbp ch\u1eadm v\u00e0o nh\u00f3m \u0111i\u1ec1u tr\u1ecb SSYX (SSYX, 4 vi\u00ean\/l\u1ea7n, 3 l\u1ea7n\/ng\u00e0y) v\u00e0 nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c (gi\u1ea3 d\u01b0\u1ee3c, 3 l\u1ea7n\/ng\u00e0y) trong 4 tu\u1ea7n, v\u1edbi c\u00e1c ch\u1ec9 s\u1ed1 ch\u00ednh l\u00e0 nh\u1ecbp tim trung b\u00ecnh, nh\u1ecbp nhanh nh\u1ea5t v\u00e0 nh\u1ecbp ch\u1eadm nh\u1ea5t. C\u00e1c ch\u1ec9 s\u1ed1 \u0111i\u1ec1u tr\u1ecb th\u1ee9 c\u1ea5p g\u1ed3m h\u1ed3i h\u1ed9p, kh\u00f3 th\u1edf, m\u1ec7t m\u1ecfi, t\u1ee9c ng\u1ef1c, m\u1ea5t ng\u1ee7 v\u00e0 \u0111\u1ed5 m\u1ed3 h\u00f4i ban \u0111\u00eam.<\/p>\n\n\n\n<p>Sau 4 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb, c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng nh\u01b0 h\u1ed3i h\u1ed9p, kh\u00f3 th\u1edf, m\u1ec7t m\u1ecfi, t\u1ee9c ng\u1ef1c, m\u1ea5t ng\u1ee7 v\u00e0 \u0111\u1ed5 m\u1ed3 h\u00f4i ban \u0111\u00eam \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n r\u00f5 r\u1ec7t \u1edf nh\u00f3m SSYX. Nh\u00f3m SSYX cho th\u1ea5y hi\u1ec7u qu\u1ea3 t\u1ed5ng th\u1ec3 cao h\u01a1n \u0111\u00e1ng k\u1ec3 (t\u1ef7 l\u1ec7 hi\u1ec7u qu\u1ea3 t\u1ed5ng th\u1ec3 63,5 %) v\u00e0 \u0111i\u1ec3m tri\u1ec7u ch\u1ee9ng t\u1ed1t h\u01a1n so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c (t\u1ef7 l\u1ec7 hi\u1ec7u qu\u1ea3 t\u1ed5ng th\u1ec3 22,1 %). Ngo\u00e0i ra, kh\u00f4ng quan s\u00e1t th\u1ea5y ph\u1ea3n \u1ee9ng ph\u1ee5 r\u00f5 r\u00e0ng. V\u1ec1 c\u1ea3i thi\u1ec7n nh\u1ecbp tim, qua theo d\u00f5i v\u00e0 \u0111\u00e1nh gi\u00e1 \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 Holter 24 gi\u1edd, nh\u00f3m SSYX cho th\u1ea5y nh\u1ecbp th\u1ea5t trung b\u00ecnh t\u0103ng 7,09 nh\u1ecbp\/ph\u00fat, \u0111\u1ed3ng th\u1eddi c\u1ea3i thi\u1ec7n nh\u1ecbp nhanh nh\u1ea5t v\u00e0 nh\u1ecbp ch\u1eadm nh\u1ea5t cao h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng.<\/p>\n\n\n\n<p>Ngo\u00e0i ra, b\u1ec7nh nh\u00e2n nh\u1ecbp ch\u1eadm xoang n\u1eb7ng c\u00f3 th\u1ec3 g\u1eb7p r\u1ed1i lo\u1ea1n c\u00e2n b\u1eb1ng giao c\u1ea3m \u2013 ph\u00f3 giao c\u1ea3m. Jin v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 nghi\u00ean c\u1ee9u t\u00e1c \u0111\u1ed9ng c\u1ee7a SSYX tr\u00ean b\u1ec7nh nh\u00e2n nh\u1ecbp ch\u1eadm xoang v\u00e0 ch\u1ee9c n\u0103ng th\u1ea7n kinh t\u1ef1 ch\u1ee7 tim. K\u1ebft qu\u1ea3 cho th\u1ea5y SSYX l\u00e0m t\u0103ng nh\u1ecbp tim \u1edf b\u1ec7nh nh\u00e2n nh\u1ecbp ch\u1eadm xoang, \u0111\u1ed3ng th\u1eddi l\u00e0m gi\u1ea3m tham s\u1ed1 HF c\u1ee7a HRV v\u00e0 \u0111\u1ed9 l\u1ec7ch chu\u1ea9n c\u1ee7a t\u1ea5t c\u1ea3 kho\u1ea3ng NN (SDNN), trong khi t\u0103ng tham s\u1ed1 LF c\u1ee7a HRV v\u00e0 t\u1ef7 s\u1ed1 LF\/HF.<\/p>\n\n\n\n<p>Do \u0111\u00f3, c\u00f3 th\u1ec3 suy \u0111o\u00e1n r\u1eb1ng SSYX c\u1ea3i thi\u1ec7n nh\u1ecbp tim v\u00e0 tri\u1ec7u ch\u1ee9ng \u1edf b\u1ec7nh nh\u00e2n nh\u1ecbp ch\u1eadm xoang b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng ph\u00f3 giao c\u1ea3m v\u00e0 t\u0103ng ho\u1ea1t \u0111\u1ed9ng giao c\u1ea3m, t\u1eeb \u0111\u00f3 ph\u1ee5c h\u1ed3i c\u00e2n b\u1eb1ng trong h\u1ec7 th\u1ea7n kinh t\u1ef1 ch\u1ee7.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">7.1.3. Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng c\u1ee7a vi\u00ean nang Shensong Yangxin trong \u201c\u0111i\u1ec1u tr\u1ecb nh\u1ecbp nhanh v\u00e0 nh\u1ecbp ch\u1eadm k\u1ebft h\u1ee3p \u0111i\u1ec1u h\u00f2a t\u1ed5ng th\u1ec3\u201d<\/h4>\n\n\n\n<p>H\u1ed9i ch\u1ee9ng nh\u1ecbp ch\u1eadm, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 h\u1ed9i ch\u1ee9ng nh\u1ecbp ch\u1eadm \u2013 nh\u1ecbp nhanh, l\u00e0 m\u1ed9t d\u1ea1ng h\u1ed9i ch\u1ee9ng n\u00fat xoang b\u1ec7nh l\u00fd \u0111\u1eb7c hi\u1ec7u, bi\u1ec3u hi\u1ec7n b\u1eb1ng nh\u1ecbp ch\u1eadm xoang, ng\u1eebng xoang ho\u1eb7c block xoang k\u1ebft h\u1ee3p v\u1edbi nh\u1ecbp nhanh tr\u00ean th\u1ea5t, cu\u1ed3ng nh\u0129 ho\u1eb7c rung nh\u0129. \u0110\u00e2y l\u00e0 m\u1ed9t h\u1ed9i ch\u1ee9ng th\u01b0\u1eddng g\u1eb7p v\u00e0 kh\u00f3 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng y h\u1ecdc T\u00e2y y th\u00f4ng th\u01b0\u1eddng. \u0110i\u1ec1u tr\u1ecb nh\u1ecbp tim ch\u1eadm xoang k\u1ebft h\u1ee3p v\u1edbi nh\u1ecbp nhanh v\u1eabn l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1 kh\u00f3 kh\u0103n. Ph\u01b0\u01a1ng ph\u00e1p th\u01b0\u1eddng d\u00f9ng l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf nh\u1ecbp nhanh k\u1ebft h\u1ee3p v\u1edbi b\u1ea3o v\u1ec7 b\u1eb1ng m\u00e1y t\u1ea1o nh\u1ecbp. Tuy nhi\u00ean, \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n kh\u00f4ng th\u1ec3 th\u1ef1c hi\u1ec7n m\u00e1y t\u1ea1o nh\u1ecbp ho\u1eb7c ph\u00e1 rung t\u1ea7n s\u1ed1 v\u00f4 tuy\u1ebfn, c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i m\u1ed9t s\u1ed1 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp th\u00f4ng th\u01b0\u1eddng, v\u00e0 vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c c\u1ed5 truy\u1ec1n \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u00e0 m\u1ed9t h\u01b0\u1edbng \u0111i\u1ec1u tr\u1ecb \u0111\u00e1ng c\u00e2n nh\u1eafc.<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng g\u1ea7n \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng SSYX kh\u00f4ng ch\u1ec9 c\u00f3 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb nh\u1ecbp nhanh m\u00e0 c\u00f2n l\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n c\u00e1c nh\u1ecbp nhanh kh\u00e1c nhau, nh\u01b0 ngo\u1ea1i t\u00e2m thu th\u1ea5t, ngo\u1ea1i t\u00e2m thu nh\u0129, nh\u1ecbp nhanh nh\u0129, cu\u1ed3ng nh\u0129 v\u00e0 nh\u1ecbp n\u00fat nh\u0129 \u2013 th\u1ea5t \u1edf b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n nh\u1ecbp m\u1ea1n t\u00ednh. Hi\u1ec7u qu\u1ea3 n\u00e0y \u0111i k\u00e8m v\u1edbi vi\u1ec7c t\u0103ng nh\u1ecbp tim trung b\u00ecnh 24 gi\u1edd, \u0111\u01b0\u1ee3c ghi nh\u1eadn qua \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 Holter.<\/p>\n\n\n\n<p>Zhang v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 x\u00e1c nh\u1eadn hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng c\u1ee7a SSYX trong \u0111i\u1ec1u tr\u1ecb nh\u1ecbp ch\u1eadm xoang k\u00e8m ngo\u1ea1i t\u00e2m thu th\u1ea5t th\u00f4ng qua m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111a trung t\u00e2m, ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c. T\u1ed5ng c\u1ed9ng 333 b\u1ec7nh nh\u00e2n c\u00f3 ngo\u1ea1i t\u00e2m thu th\u1ea5t tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng xuy\u00ean v\u00e0 nh\u1ecbp ch\u1eadm xoang \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean v\u00e0o nh\u00f3m SSYX ho\u1eb7c nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c. Sau 8 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb, nh\u00f3m SSYX cho th\u1ea5y c\u1ea3i thi\u1ec7n r\u00f5 r\u1ec7t v\u1ec1 nh\u1ecbp tim t\u1ed1i \u0111a, nh\u1ecbp tim trung b\u00ecnh v\u00e0 t\u1ed5ng s\u1ed1 nh\u1ecbp \u0111\u1eadp theo ghi nh\u1eadn Holter. Nh\u1ecbp tim trung b\u00ecnh t\u0103ng \u0111\u00e1ng k\u1ec3 10,9 % \u1edf nh\u00f3m SSYX, trong khi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c t\u0103ng 4,7 %. V\u1ec1 \u0111i\u1ec1u h\u00f2a ngo\u1ea1i t\u00e2m thu th\u1ea5t, SSYX gi\u1ea3m t\u1ea3i ngo\u1ea1i t\u00e2m thu th\u1ea5t 68,2 %, c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea so v\u1edbi 32,2 % \u1edf nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n\n\n\n<p>Ngo\u00e0i ra, Yang v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 t\u1ed5ng h\u1ee3p c\u00e1c b\u00e0i b\u00e1o li\u00ean quan \u0111\u1ebfn c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean v\u1ec1 SSYX trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n nh\u1ecbp m\u1ea1n t\u00ednh k\u00e8m ngo\u1ea1i t\u00e2m thu \u0111\u1ec3 th\u1ef1c hi\u1ec7n ph\u00e2n t\u00edch g\u1ed9p. C\u00e1c ch\u1ec9 s\u1ed1 ch\u00ednh ph\u1ea3n \u00e1nh hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng c\u1ee7a SSYX cho \u0111i\u1ec1u tr\u1ecb nh\u1ecbp ch\u1eadm bao g\u1ed3m nh\u1ecbp tim trung b\u00ecnh, t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng nh\u1ecbp ch\u1eadm v\u00e0 t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng. T\u1ed5ng c\u1ed9ng c\u00f3 9 nghi\u00ean c\u1ee9u v\u1edbi 706 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o ph\u00e2n t\u00edch g\u1ed9p: SSYX l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 nh\u1ecbp tim trung b\u00ecnh \u1edf b\u1ec7nh nh\u00e2n nh\u1ecbp ch\u1eadm k\u00e8m ngo\u1ea1i t\u00e2m thu th\u1ea5t, c\u1ea3i thi\u1ec7n r\u00f5 r\u1ec7t t\u1ef7 l\u1ec7 hi\u1ec7u qu\u1ea3 c\u1ee7a ngo\u1ea1i t\u00e2m thu th\u1ea5t, nh\u1ecbp ch\u1eadm v\u00e0 t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng, \u0111\u1ed3ng th\u1eddi kh\u00f4ng quan s\u00e1t th\u1ea5y ph\u1ea3n \u1ee9ng ph\u1ee5 \u0111\u00e1ng k\u1ec3.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">7.2. Nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1ec1 vi\u00ean nang Shensong Yangxin trong \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i t\u00e2m thu th\u1ea5t k\u00e8m r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng tim<\/h4>\n\n\n\n<p>Ngo\u1ea1i t\u00e2m thu th\u1ea5t l\u00e0 r\u1ed1i lo\u1ea1n nh\u1ecbp th\u01b0\u1eddng g\u1eb7p nh\u1ea5t trong l\u00e2m s\u00e0ng. Khi suy tim \u0111i k\u00e8m ngo\u1ea1i t\u00e2m thu th\u1ea5t, t\u00ecnh tr\u1ea1ng huy\u1ebft \u0111\u1ed9ng b\u1ecb x\u00e1o tr\u1ed9n, b\u1ec7nh nh\u00e2n tr\u1edf n\u00ean n\u1eb7ng h\u01a1n, v\u00e0 t\u1ef7 l\u1ec7 t\u1eed vong t\u0103ng cao. Ngo\u1ea1i t\u00e2m thu th\u1ea5t v\u00e0 suy tim c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c t\u1ea1o th\u00e0nh m\u1ed9t v\u00f2ng lu\u1ea9n qu\u1ea9n. Hi\u1ec7n nay, h\u1ea7u h\u1ebft c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp d\u00f9ng \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i t\u00e2m thu th\u1ea5t c\u00f3 \u1ea3nh h\u01b0\u1edfng ti\u00eau c\u1ef1c \u0111\u1ebfn ch\u1ee9c n\u0103ng tim v\u00e0 l\u00e0m t\u0103ng t\u1ef7 l\u1ec7 t\u1eed vong. C\u00e1c li\u1ec7u ph\u00e1p kh\u00f4ng d\u00f9ng thu\u1ed1c, nh\u01b0 ph\u00e1 rung b\u1eb1ng catheter t\u1ea7n s\u1ed1 v\u00f4 tuy\u1ebfn c\u1ea5y gh\u00e9p v\u00e0 \u0111i\u1ec1u h\u00f2a \u0111\u1ed3ng b\u1ed9 tim, \u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i t\u00e2m thu th\u1ea5t k\u00e8m r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng tim. Tuy nhi\u00ean, nhi\u1ec1u b\u1ec7nh nh\u00e2n v\u1eabn kh\u00f4ng nh\u1eadn \u0111\u01b0\u1ee3c can thi\u1ec7p hi\u1ec7u qu\u1ea3. Do \u0111\u00f3, vi\u1ec7c t\u00ecm ki\u1ebfm c\u00e1c thu\u1ed1c thay th\u1ebf cho \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i t\u00e2m thu th\u1ea5t k\u00e8m suy tim m\u1ea1n t\u00ednh l\u00e0 r\u1ea5t quan tr\u1ecdng v\u00e0 c\u1ea5p b\u00e1ch.<\/p>\n\n\n\n<p>Wang v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 ti\u1ebfn h\u00e0nh m\u1ed9t nghi\u00ean c\u1ee9u ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c, \u0111a trung t\u00e2m, bao g\u1ed3m 465 b\u1ec7nh nh\u00e2n suy tim m\u1ea1n t\u00ednh k\u00e8m ngo\u1ea1i t\u00e2m thu th\u1ea5t th\u01b0\u1eddng xuy\u00ean, \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean v\u00e0o nh\u00f3m SSYX (n = 232) v\u00e0 nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c (n = 233) trong 12 tu\u1ea7n. S\u1ed1 l\u01b0\u1ee3ng ngo\u1ea1i t\u00e2m thu th\u1ea5t \u0111\u01b0\u1ee3c theo d\u00f5i b\u1eb1ng \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 Holter 24 gi\u1edd \u0111\u01b0\u1ee3c ch\u1ecdn l\u00e0m ch\u1ec9 s\u1ed1 \u0111i\u1ec1u tr\u1ecb ch\u00ednh. C\u00e1c ch\u1ec9 s\u1ed1 \u0111i\u1ec1u tr\u1ecb ph\u1ee5 bao g\u1ed3m: ph\u00e2n su\u1ea5t t\u1ed1ng m\u00e1u th\u1ea5t tr\u00e1i (LVEF), \u0111\u01b0\u1eddng k\u00ednh cu\u1ed1i t\u00e2m tr\u01b0\u01a1ng th\u1ea5t tr\u00e1i, m\u1ee9c peptide natriuretic N-terminal n\u00e3o (NT-proBNP), ph\u00e2n \u0111\u1ed9 NYHA, kho\u1ea3ng c\u00e1ch \u0111i b\u1ed9 6 ph\u00fat (6 MWD), \u0111i\u1ec3m s\u1ed1 Minnesota Heart Failure Life Questionnaire (MLHFQ), v\u00e0 c\u00e1c bi\u1ebfn c\u1ed1 tim ph\u1ee9c t\u1ea1p (CCEs). K\u1ebft qu\u1ea3 cho th\u1ea5y t\u1ed5ng s\u1ed1 ngo\u1ea1i t\u00e2m thu th\u1ea5t \u1edf nh\u00f3m SSYX gi\u1ea3m \u0111\u00e1ng k\u1ec3 so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c, v\u1edbi xu h\u01b0\u1edbng gi\u1ea3m \u1edf c\u00e1c lo\u1ea1i ngo\u1ea1i t\u00e2m thu th\u1ea5t \u0111\u01a1n h\u00ecnh, \u0111a h\u00ecnh, \u0111a \u1ed5, c\u1eb7p, \u0111\u00f4i v\u00e0 ba. Trong c\u00e1c ch\u1ec9 s\u1ed1 ph\u1ee5, \u0111i\u1ec1u tr\u1ecb b\u1eb1ng SSYX c\u1ea3i thi\u1ec7n ph\u00e2n \u0111\u1ed9 NYHA v\u00e0 t\u0103ng LVEF. SSYX c\u0169ng gi\u00fap gi\u1ea3m m\u1ee9c NT-proBNP huy\u1ebft t\u01b0\u01a1ng, c\u1ea3i thi\u1ec7n kho\u1ea3ng c\u00e1ch \u0111i b\u1ed9 6 ph\u00fat v\u00e0 \u0111i\u1ec3m s\u1ed1 ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng. T\u1ea5t c\u1ea3 d\u1eef li\u1ec7u \u0111\u1ec1u cho th\u1ea5y SSYX v\u01b0\u1ee3t tr\u1ed9i h\u01a1n gi\u1ea3 d\u01b0\u1ee3c, kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u00e1ng k\u1ec3. Do \u0111\u00f3, SSYX v\u1eeba \u1ee9c ch\u1ebf ngo\u1ea1i t\u00e2m thu th\u1ea5t v\u1eeba c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng tim.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">7.3. Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng c\u1ee7a vi\u00ean nang Shensong Yangxin trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh tim m\u1ea1ch kh\u00e1c<\/h4>\n\n\n\n<p>Liu v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u00e1nh gi\u00e1 h\u1ec7 th\u1ed1ng Cochrane \u0111\u1ec3 ti\u1ebfn h\u00e0nh t\u1ed5ng quan c\u00f3 h\u1ec7 th\u1ed1ng c\u00e1c th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean c\u00f3 ki\u1ec3m so\u00e1t v\u1ec1 SSYX trong \u0111i\u1ec1u tr\u1ecb th\u1ea7n kinh tim. Nghi\u00ean c\u1ee9u n\u00e0y cho th\u1ea5y SSYX c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng nh\u01b0 t\u1ee9c ng\u1ef1c, kh\u00f3 th\u1edf, m\u1ea5t ng\u1ee7 v\u00e0 c\u00e1u g\u1eaft \u1edf b\u1ec7nh nh\u00e2n th\u1ea7n kinh tim, \u0111\u1ed3ng th\u1eddi gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng ngo\u1ea1i t\u00e2m thu th\u1ea5t \u0111\u01b0\u1ee3c theo d\u00f5i b\u1eb1ng Holter. Hi\u1ec7u qu\u1ea3 t\u1ed5ng th\u1ec3 c\u1ee7a SSYX \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi y h\u1ecdc T\u00e2y y th\u00f4ng th\u01b0\u1eddng.<\/p>\n\n\n\n<p>Liu v\u00e0 c\u1ed9ng s\u1ef1 c\u0169ng so s\u00e1nh hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a nh\u00f3m SSYX v\u1edbi c\u00e1c nh\u00f3m \u0111\u1ed1i ch\u1ee9ng T\u00e2y y, nh\u01b0 ribavirin, Coenzyme Q10, vitamin C, trong \u0111i\u1ec1u tr\u1ecb vi\u00eam c\u01a1 tim b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p ng\u1eabu nhi\u00ean m\u1edf r\u1ed9ng. K\u1ebft qu\u1ea3 cho th\u1ea5y c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng t\u1ee9c ng\u1ef1c, kh\u00f3 th\u1edf, m\u1ec7t m\u1ecfi, v\u00e0 \u0111\u1ed5 m\u1ed3 h\u00f4i t\u1ef1 ph\u00e1t \u1edf nh\u00f3m SSYX r\u00f5 r\u1ec7t h\u01a1n nh\u00f3m \u0111\u1ed1i ch\u1ee9ng. Ngo\u00e0i ra, SSYX c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 m\u1ee9c AST, LDH, CPK v\u00e0 CPK-MB, cho th\u1ea5y t\u00e1c d\u1ee5ng quan tr\u1ecdng trong vi\u00eam c\u01a1 tim do virus.<\/p>\n\n\n\n<p>Li v\u00e0 c\u1ed9ng s\u1ef1 ph\u00e1t hi\u1ec7n r\u1eb1ng SSYX k\u1ebft h\u1ee3p v\u1edbi edaravone c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o k\u00e8m h\u1ed9i ch\u1ee9ng tim \u2013 n\u00e3o, c\u1ea3i thi\u1ec7n c\u00e1c m\u1ee9c norepinephrine, epinephrine, dopamine, malondialdehyde huy\u1ebft thanh, v\u00e0 superoxide dismutase, \u0111\u1ed3ng th\u1eddi kh\u00f4ng l\u00e0m t\u0103ng t\u1ef7 l\u1ec7 t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n\n\n\n<p>Ngo\u00e0i ra, SSYX c\u00f2n \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 trong tr\u1ea7m c\u1ea3m th\u1eddi k\u1ef3 m\u00e3n kinh, h\u1ed9i ch\u1ee9ng ti\u1ec1n m\u00e3n kinh, m\u1ea5t ng\u1ee7, v\u00e0 ch\u00f3ng m\u1eb7t h\u1ea1 huy\u1ebft \u00e1p.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">7.4. \u0110\u00e1nh gi\u00e1 an to\u00e0n c\u1ee7a vi\u00ean nang Shensong Yangxin trong \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng<\/h4>\n\n\n\n<p>Trong m\u1ed9t nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n, th\u1eed nghi\u1ec7m \u0111\u1ed9c t\u00ednh c\u1ea5p t\u00ednh cho th\u1ea5y li\u1ec1u dung n\u1ea1p t\u1ed1i \u0111a c\u1ee7a SSYX \u0111\u01b0\u1eddng u\u1ed1ng \u1edf chu\u1ed9t l\u00e0 129,6 g d\u01b0\u1ee3c li\u1ec7u th\u00f4 tr\u00ean kg tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 524 l\u1ea7n so v\u1edbi li\u1ec1u d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n l\u00e2m s\u00e0ng. H\u01a1n n\u1eefa, m\u1ed9t nghi\u00ean c\u1ee9u \u0111\u1ed9c t\u00ednh th\u00ed nghi\u1ec7m k\u00e9o d\u00e0i 3 th\u00e1ng cho th\u1ea5y SSYX kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn 10 ch\u1ec9 s\u1ed1 sinh h\u00f3a, bao g\u1ed3m tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3, l\u01b0\u1ee3ng \u0103n u\u1ed1ng, \u0111i\u1ec7n t\u00e2m \u0111\u1ed3, h\u00ecnh \u1ea3nh m\u00e1u, ch\u1ee9c n\u0103ng gan \u2013 th\u1eadn, v\u00e0 kh\u00f4ng g\u00e2y b\u1ea5t k\u1ef3 thay \u0111\u1ed5i b\u1ec7nh l\u00fd m\u00f4 h\u1ecdc n\u00e0o \u1edf c\u00e1c c\u01a1 quan.<\/p>\n\n\n\n<p>Huang v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 ti\u1ebfn h\u00e0nh c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean, ki\u1ec3m so\u00e1t l\u1edbn, d\u1ef1a tr\u00ean b\u1eb1ng ch\u1ee9ng v\u1ec1 b\u1ec7nh m\u1ea1ch v\u00e0nh, lo\u1ea1n nh\u1ecbp v\u00e0 suy ch\u1ee9c n\u0103ng tim m\u1ea1n t\u00ednh. C\u00e1c nghi\u00ean c\u1ee9u ch\u1ee9ng minh r\u1eb1ng, so v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp c\u00f3 b\u1ea3n quy\u1ec1n kh\u00e1c c\u1ee7a Trung y, SSYX \u00edt g\u00e2y t\u00e1c d\u1ee5ng ph\u1ee5 l\u00e2m s\u00e0ng h\u01a1n trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh tim m\u1ea1ch, nh\u01b0 ch\u00f3ng m\u1eb7t tho\u00e1ng qua, ph\u00e1t ban, v\u00e0 \u0111\u1ea7y b\u1ee5ng.<\/p>\n\n\n\n<p>So v\u1edbi thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp T\u00e2y y, m\u1ed9t ph\u00e2n t\u00edch g\u1ed9p v\u1ec1 \u0111\u1ed9 an to\u00e0n c\u1ee7a SSYX trong \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp cho th\u1ea5y t\u1ef7 l\u1ec7 lo\u1ea1n nh\u1ecbp do SSYX th\u1ea5p h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi amiodarone v\u00e0 arrhythapine, cho th\u1ea5y SSYX c\u00f3 l\u1ee3i th\u1ebf trong \u0111i\u1ec1u tr\u1ecb \u0111a m\u1ee5c ti\u00eau v\u00e0 an to\u00e0n v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp hi\u1ec7n h\u00e0nh.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">8. K\u1ebft lu\u1eadn<\/h4>\n\n\n\n<p>Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp \u0111\u01a1n k\u00eanh ion truy\u1ec1n th\u1ed1ng th\u01b0\u1eddng kh\u00f4ng l\u00fd t\u01b0\u1edfng, trong khi c\u00e1c thu\u1ed1c \u0111a k\u00eanh ion c\u00f3 th\u1ec3 gi\u1ea3m s\u1ef1 ph\u00e2n t\u00e1n \u0111i\u1ec7n c\u1ee7a c\u01a1 tim \u1edf m\u1ee9c \u0111\u1ed9 nh\u1ea5t \u0111\u1ecbnh; tuy nhi\u00ean, c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u00e1ng k\u1ec3 th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n khi s\u1eed d\u1ee5ng l\u00e2u d\u00e0i. SSYX c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp, c\u1ea3 \u1edf m\u1ee9c tri\u1ec7u ch\u1ee9ng l\u1eabn nguy\u00ean nh\u00e2n g\u1ed1c r\u1ec5, th\u00f4ng qua \u00e1p d\u1ee5ng nguy\u00ean t\u1eafc Y h\u1ecdc c\u1ed5 truy\u1ec1n \u201cnhi\u1ec1u m\u1eaft x\u00edch \u2013 nhi\u1ec1u m\u1ee5c ti\u00eau\u201d nh\u1eb1m \u1ee9c ch\u1ebf s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a lo\u1ea1n nh\u1ecbp v\u00e0 c\u1ea3i thi\u1ec7n ti\u00ean l\u01b0\u1ee3ng cho b\u1ec7nh nh\u00e2n. Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng khi \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp b\u1eb1ng SSYX l\u00e0 t\u00edch c\u1ef1c, v\u1edbi \u00edt t\u00e1c d\u1ee5ng ph\u1ee5. C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u0111\u00e3 ch\u1ee9ng minh SSYX c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb nh\u1ecbp tim nhanh, ngo\u1ea1i t\u00e2m thu th\u1ea5t, rung nh\u0129 c\u01a1n k\u1ecbch ph\u00e1t, \u0111\u1ed3ng th\u1eddi c\u1ea3i thi\u1ec7n nh\u1ecbp th\u1ea5t trong lo\u1ea1n nh\u1ecbp m\u1ea1n t\u00ednh v\u00e0 \u0111\u1ea1t hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng \u0111o l\u01b0\u1eddng \u0111\u01b0\u1ee3c.<\/p>\n\n\n\n<p>H\u01a1n n\u1eefa, SSYX c\u00f3 nh\u1eefng \u01b0u th\u1ebf \u0111\u1eb7c th\u00f9 so v\u1edbi thu\u1ed1c T\u00e2y y trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1ec1 \u0111i\u1ec1u tr\u1ecb suy ch\u1ee9c n\u0103ng tim k\u1ebft h\u1ee3p v\u1edbi ngo\u1ea1i t\u00e2m thu th\u1ea5t. C\u00e1c nghi\u00ean c\u1ee9u c\u01a1 ch\u1ebf cho th\u1ea5y SSYX c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf nhi\u1ec1u k\u00eanh ion nh\u01b0 k\u00eanh Na\u207a, Ca\u00b2\u207a v\u00e0 K\u207a, v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng lo\u1ea1n nh\u1ecbp ph\u1ed5 r\u1ed9ng. Ngo\u00e0i ra, SSYX c\u00f2n c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng n\u00fat xoang v\u00e0 d\u1eabn truy\u1ec1n tim b\u1eb1ng c\u00e1ch n\u00e2ng cao d\u1eabn truy\u1ec1n n\u00fat xoang v\u00e0 r\u00fat ng\u1eafn th\u1eddi gian t\u00e1i c\u1ef1c (APD). \u0110\u1ed3ng th\u1eddi, n\u00f3 th\u1ec3 hi\u1ec7n nhi\u1ec1u t\u00e1c d\u1ee5ng kh\u00e1c nh\u01b0 \u1ee9c ch\u1ebf x\u01a1 h\u00f3a c\u01a1 tim, \u0111i\u1ec1u h\u00f2a ch\u1ee9c n\u0103ng th\u1ea7n kinh t\u1ef1 ch\u1ee7 tim, gi\u1ea3m ph\u1ea3n \u1ee9ng vi\u00eam c\u01a1 tim, c\u1ea3i thi\u1ec7n chuy\u1ec3n h\u00f3a n\u0103ng l\u01b0\u1ee3ng ty th\u1ec3, n\u00e2ng cao ch\u1ee9c n\u0103ng n\u1ed9i m\u00f4 vi m\u1ea1ch, th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u1ea1o m\u1ea1ch v\u00e0 \u0111i\u1ec1u ch\u1ec9nh c\u00e1c c\u01a1 ch\u1ebf kh\u00f4ng li\u00ean quan k\u00eanh ion. T\u1ea5t c\u1ea3 nh\u1eefng t\u00e1c \u0111\u1ed9ng n\u00e0y \u0111\u00f3ng g\u00f3p v\u00e0o chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1edbi \u201c\u0111i\u1ec1u tr\u1ecb nhanh \u2013 ch\u1eadm k\u1ebft h\u1ee3p \u0111i\u1ec1u h\u00f2a to\u00e0n di\u1ec7n\u201d trong qu\u1ea3n l\u00fd lo\u1ea1n nh\u1ecbp, hi\u1ec7n th\u1ef1c h\u00f3a s\u1ef1 chuy\u1ec3n \u0111\u1ed5i trong t\u01b0 duy \u0111i\u1ec1u tr\u1ecb t\u1eeb \u201cch\u1ed1ng ph\u00e1p\u201d sang \u201c\u0111i\u1ec1u h\u00f2a ph\u00e1p\u201d. Tuy nhi\u00ean, lo\u1ea1n nh\u1ecbp l\u00e0 m\u1ed9t qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd li\u00ean quan \u0111\u1ebfn t\u01b0\u01a1ng t\u00e1c \u0111a y\u1ebfu t\u1ed1, v\u00e0 c\u01a1 ch\u1ebf c\u1ee7a n\u00f3 ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m r\u00f5 ho\u00e0n to\u00e0n.<\/p>\n\n\n\n<p>SSYX, l\u00e0 m\u1ed9t c\u00f4ng th\u1ee9c Y h\u1ecdc c\u1ed5 truy\u1ec1n, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp. Tuy nhi\u00ean, c\u1ea7n c\u00f3 th\u00eam nghi\u00ean c\u1ee9u \u0111\u1ec3 l\u00e0m r\u00f5 c\u01a1 s\u1edf v\u1eadt ch\u1ea5t v\u00e0 c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a ho\u1ea1t t\u00ednh \u0111a t\u00e1c d\u1ee5ng n\u00e0y. D\u01b0\u1ee3c l\u00fd m\u1ea1ng l\u01b0\u1edbi (network pharmacology) cung c\u1ea5p kh\u1ea3 n\u0103ng kh\u00e1m ph\u00e1 c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a SSYX trong \u0111i\u1ec1u tr\u1ecb lo\u1ea1n nh\u1ecbp v\u00e0 c\u00e1c b\u1ec7nh tim kh\u00e1c th\u00f4ng qua c\u00e1ch ti\u1ebfp c\u1eadn \u201c\u0111a th\u00e0nh ph\u1ea7n, \u0111a m\u1ee5c ti\u00eau, \u0111a \u0111\u01b0\u1eddng d\u1eabn\u201d \u1edf c\u1ea5p h\u1ec7 th\u1ed1ng. Trong nghi\u00ean c\u1ee9u n\u00e0y, c\u00e1c m\u1ee5c ti\u00eau quan tr\u1ecdng c\u1ee7a t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb, bao g\u1ed3m RYR1, RYR2, CALM1, CACNA1C, ADRA1B, ADRB2, MAPK, INS, v\u00e0 END1, \u0111\u01b0\u1ee3c cho l\u00e0 x\u1ee9ng \u0111\u00e1ng \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u s\u00e2u trong c\u00e1c nghi\u00ean c\u1ee9u ti\u1ebfp theo.<\/p>\n\n\n\n<p>Do \u0111\u00f3, c\u1ea7n m\u1edf r\u1ed9ng l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u \u0111\u1ec3 ti\u1ebfn h\u00e0nh c\u00e1c nghi\u00ean c\u1ee9u l\u00fd thuy\u1ebft s\u00e2u nh\u1eb1m l\u00e0m r\u00f5 c\u01a1 s\u1edf t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd, bao g\u1ed3m c\u00e1c hi\u1ec7u \u1ee9ng \u0111a th\u00e0nh ph\u1ea7n, \u0111a m\u1ee5c ti\u00eau, \u0111a \u0111\u01b0\u1eddng d\u1eabn, c\u0169ng nh\u01b0 c\u01a1 ch\u1ebf t\u01b0\u01a1ng t\u00e1c n\u1ec1n t\u1ea3ng c\u1ee7a SSYX in vivo. \u0110\u1ed3ng th\u1eddi, d\u1ef1a tr\u00ean c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean, \u0111a trung t\u00e2m, quy m\u00f4 l\u1edbn \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh theo y h\u1ecdc d\u1ef1a tr\u00ean b\u1eb1ng ch\u1ee9ng, hi\u1ec7u qu\u1ea3 t\u1ed5ng th\u1ec3 c\u1ee7a SSYX tr\u00ean c\u00e1c b\u1ec7nh tim m\u1ea1ch, \u0111\u1eb7c bi\u1ec7t l\u00e0 lo\u1ea1n nh\u1ecbp, c\u1ea7n \u0111\u01b0\u1ee3c kh\u00e1m ph\u00e1 th\u00eam.<\/p>\n<!-- relpost-thumb-wrapper --><div class=\"relpost-thumb-wrapper\"><!-- filter-class --><div class=\"relpost-thumb-container\"><style>.relpost-block-single-image, .relpost-post-image { margin-bottom: 10px; }<\/style><h3>Related posts:<\/h3><div style=\"clear: both\"><\/div><div style=\"clear: both\"><\/div><!-- relpost-block-container --><div class=\"relpost-block-container relpost-block-column-layout\" style=\"--relposth-columns: 3;--relposth-columns_t: 2; --relposth-columns_m: 2\"><a href=\"https:\/\/thuoc115.com\/suckhoe\/hoang-ky-that-diep-nhat-chi-hoa-cho-ung-thu-phoi-khong-te-bao-nho-nsclc\/\"class=\"relpost-block-single\" ><div class=\"relpost-custom-block-single\"><div class=\"relpost-block-single-image rpt-lazyload\" aria-hidden=\"true\" role=\"img\" data-bg=\"https:\/\/thuoc115.com\/suckhoe\/wp-content\/plugins\/related-posts-thumbnails\/img\/default.png\" style=\"background: transparent no-repeat scroll 0% 0%; width: 150px; height: 150px; aspect-ratio: 1\/1;\"><\/div><div class=\"relpost-block-single-text\"  style=\"height: 75px;font-family: Arial;  font-size: 12px;  color: #333333;\"><h2 class=\"relpost_card_title\">Ho\u00e0ng K\u1ef3, th\u1ea5t di\u1ec7p nh\u1ea5t chi hoa cho Ung th\u01b0 ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf (NSCLC)<\/h2><\/div><\/div><\/a><a href=\"https:\/\/thuoc115.com\/suckhoe\/chuc-nang-sinh-ly-tang-than-va-phu-bang-quang\/\"class=\"relpost-block-single\" ><div class=\"relpost-custom-block-single\"><div 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th\u01b0\u1eddng g\u1eb7p &#8230; <a title=\"Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m gi\u1ea3m nguy c\u01a1 r\u1ed1i lo\u1ea1n nh\u1ecbp tim\" class=\"read-more\" href=\"https:\/\/thuoc115.com\/suckhoe\/than-tong-duong-tam-giam-nguy-co-roi-loan-nhip-tim\/\" aria-label=\"\u0110\u1ecdc th\u00eam v\u1ec1 Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m gi\u1ea3m nguy c\u01a1 r\u1ed1i lo\u1ea1n nh\u1ecbp tim\">\u0110\u1ecdc ti\u1ebfp<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-527","post","type-post","status-publish","format-standard","hentry","category-duoc-lieu"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m gi\u1ea3m nguy c\u01a1 r\u1ed1i lo\u1ea1n nh\u1ecbp tim - Th\u00f4ng tin s\u1ee9c kh\u1ecfe<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/thuoc115.com\/suckhoe\/than-tong-duong-tam-giam-nguy-co-roi-loan-nhip-tim\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Th\u1ea7n T\u00f4ng D\u01b0\u1ee1ng T\u00e2m gi\u1ea3m nguy c\u01a1 r\u1ed1i lo\u1ea1n nh\u1ecbp tim - Th\u00f4ng tin s\u1ee9c kh\u1ecfe\" \/>\n<meta property=\"og:description\" content=\"R\u1ed1i lo\u1ea1n nh\u1ecbp tim (Arrhythmia) l\u00e0 m\u1ed9t b\u1ec7nh tim m\u1ea1ch (CVD) ph\u1ed5 bi\u1ebfn, ch\u1ec9 b\u1ea5t k\u1ef3 b\u1ea5t th\u01b0\u1eddng n\u00e0o v\u1ec1 ngu\u1ed3n g\u1ed1c, t\u1ea7n s\u1ed1, nh\u1ecbp \u0111i\u1ec7u, v\u1eadn t\u1ed1c d\u1eabn truy\u1ec1n, th\u1eddi gian, \u0111\u01b0\u1eddng \u0111i, tr\u00ecnh t\u1ef1 ho\u1eb7c c\u00e1c kh\u00eda c\u1ea1nh kh\u00e1c c\u1ee7a xung \u0111\u1ed9ng tim, v\u00e0 l\u00e0 m\u1ed9t trong nh\u1eefng b\u1ec7nh tim m\u1ea1ch th\u01b0\u1eddng g\u1eb7p ... \u0110\u1ecdc ti\u1ebfp\" \/>\n<meta property=\"og:url\" content=\"https:\/\/thuoc115.com\/suckhoe\/than-tong-duong-tam-giam-nguy-co-roi-loan-nhip-tim\/\" \/>\n<meta property=\"og:site_name\" content=\"Th\u00f4ng tin s\u1ee9c kh\u1ecfe\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-25T20:45:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-25T22:58:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cdn.ncbi.nlm.nih.gov\/pmc\/blobs\/ee89\/11367280\/55f45b5347d3\/gr1.jpg\" \/>\n<meta name=\"author\" content=\"Th\u1ea1c s\u0129 Nguy\u1ec5n \u0110\u0103ng H\u1ea3i\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi\" \/>\n\t<meta name=\"twitter:data1\" content=\"Th\u1ea1c s\u0129 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