{"id":510,"date":"2026-03-15T07:58:26","date_gmt":"2026-03-15T07:58:26","guid":{"rendered":"https:\/\/thuoc115.com\/suckhoe\/?p=510"},"modified":"2026-03-15T07:58:27","modified_gmt":"2026-03-15T07:58:27","slug":"hieu-qua-va-tinh-an-toan-cua-com-cong-thuc-thao-duoc-trong-dieu-tri-benh-than-man-giai-doan-3","status":"publish","type":"post","link":"https:\/\/thuoc115.com\/suckhoe\/hieu-qua-va-tinh-an-toan-cua-com-cong-thuc-thao-duoc-trong-dieu-tri-benh-than-man-giai-doan-3\/","title":{"rendered":"Hi\u1ec7u qu\u1ea3 v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a c\u1ed1m c\u00f4ng th\u1ee9c th\u1ea3o d\u01b0\u1ee3c trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn m\u1ea1n giai \u0111o\u1ea1n 3"},"content":{"rendered":"\n<p>Th\u00f4ng th\u01b0\u1eddng ng\u01b0\u1eddi ta cho r\u1eb1ng li\u1ec7u ph\u00e1p <strong>Y h\u1ecdc c\u1ed5 truy\u1ec1n <\/strong> c\u00f3 th\u1ec3 <strong>l\u00e0m ch\u1eadm s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a m\u1ed9t s\u1ed1 b\u1ec7nh th\u1eadn m\u1ea1n t\u00ednh<\/strong>. C\u00e1c <strong>d\u01b0\u1ee3c li\u1ec7u th\u1ea3o m\u1ed9c Trung y<\/strong> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb. \u0110\u1eb7c bi\u1ec7t l\u00e0 b\u00e0i \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u1eadn do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u n\u00e0y nh\u1eb1m \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a c\u1ed1m c\u00f4ng th\u1ee9c th\u1ea3o d\u01b0\u1ee3c Trung y \u1edf b\u1ec7nh nh\u00e2n Chronic Kidney Disease (CKD) giai \u0111o\u1ea1n 3 th\u00f4ng qua m\u1ed9t nghi\u00ean c\u1ee9u ti\u1ec1n c\u1ee9u, ng\u1eabu nhi\u00ean, c\u00f3 \u0111\u1ed1i ch\u1ee9ng.<\/p>\n\n\n\n<p>Ph\u01b0\u01a1ng ph\u00e1p (Methods)<\/p>\n\n\n\n<p>T\u1ed5ng c\u1ed9ng 343 b\u1ec7nh nh\u00e2n CKD giai \u0111o\u1ea1n 3 \u0111\u01b0\u1ee3c tuy\u1ec3n ch\u1ecdn t\u1eeb 9 b\u1ec7nh vi\u1ec7n t\u1ea1i t\u1ec9nh Giang T\u00f4 (Trung Qu\u1ed1c) trong kho\u1ea3ng th\u1eddi gian t\u1eeb th\u00e1ng 4\/2014 \u0111\u1ebfn th\u00e1ng 10\/2016.<\/p>\n\n\n\n<p>Nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean v\u00e0o hai nh\u00f3m:<\/p>\n\n\n\n<p>Nh\u00f3m \u0111i\u1ec1u tr\u1ecb: u\u1ed1ng c\u1ed1m c\u00f4ng th\u1ee9c th\u1ea3o d\u01b0\u1ee3c Trung y 2 l\u1ea7n m\u1ed7i ng\u00e0y.<\/p>\n\n\n\n<p>Th\u00e0nh ph\u1ea7n ch\u00ednh (c\u00f4ng th\u1ee9c th\u01b0\u1eddng d\u00f9ng trong nghi\u00ean c\u1ee9u)<\/p>\n\n\n\n<p>C\u00e1c b\u00e0i d\u1ea1ng n\u00e0y th\u01b0\u1eddng g\u1ed3m: Ho\u00e0ng k\u1ef3, \u0110an s\u00e2m, Xuy\u00ean khung, Ph\u1ee5c linh, Tr\u1ea1ch t\u1ea3, S\u01a1n d\u01b0\u1ee3c, \u0110\u1ed7 tr\u1ecdng<\/p>\n\n\n\n<p>C\u01a1 ch\u1ebf \u0111\u1ec1 xu\u1ea5t : gi\u1ea3m vi\u00eam c\u1ea7u th\u1eadn, ch\u1ed1ng x\u01a1 h\u00f3a th\u1eadn, c\u1ea3i thi\u1ec7n vi tu\u1ea7n ho\u00e0n<\/p>\n\n\n\n<p>Nh\u00f3m \u0111\u1ed1i ch\u1ee9ng: d\u00f9ng c\u1ed1m gi\u1ea3 d\u01b0\u1ee3c (placebo).<\/p>\n\n\n\n<p>Th\u1eddi gian can thi\u1ec7p: 24 tu\u1ea7n.<\/p>\n\n\n\n<p>C\u00e1c ch\u1ec9 s\u1ed1 \u0111\u00e1nh gi\u00e1 ch\u00ednh g\u1ed3m:<\/p>\n\n\n\n<p>Protein ni\u1ec7u 24 gi\u1edd<\/p>\n\n\n\n<p>Creatinin huy\u1ebft thanh<\/p>\n\n\n\n<p>estimated glomerular filtration rate (eGFR \u2013 m\u1ee9c l\u1ecdc c\u1ea7u th\u1eadn \u01b0\u1edbc t\u00ednh)<\/p>\n\n\n\n<p>C\u00e1c ch\u1ec9 s\u1ed1 n\u00e0y \u0111\u01b0\u1ee3c \u0111o m\u1ed7i 4 tu\u1ea7n.<\/p>\n\n\n\n<p>K\u1ebft qu\u1ea3 (Results)<\/p>\n\n\n\n<p>Protein ni\u1ec7u 24 gi\u1edd:<br>Kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea gi\u1eefa hai nh\u00f3m<\/p>\n\n\n\n<p>Nh\u00f3m \u0111i\u1ec1u tr\u1ecb: 0.97 \u00b1 1.14 g\/ng\u00e0y<\/p>\n\n\n\n<p>Nh\u00f3m \u0111\u1ed1i ch\u1ee9ng: 0.97 \u00b1 1.25 g\/ng\u00e0y<\/p>\n\n\n\n<p>Creatinin huy\u1ebft thanh:<br>Nh\u00f3m \u0111i\u1ec1u tr\u1ecb th\u1ea5p h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng<\/p>\n\n\n\n<p>\u0110i\u1ec1u tr\u1ecb: 130.78 \u00b1 32.55 \u03bcmol\/L<\/p>\n\n\n\n<p>\u0110\u1ed1i ch\u1ee9ng: 149.12 \u00b1 41.27 \u03bcmol\/L<\/p>\n\n\n\n<p>eGFR:<br>Nh\u00f3m \u0111i\u1ec1u tr\u1ecb cao h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng<\/p>\n\n\n\n<p>\u0110i\u1ec1u tr\u1ecb: 55.74 \u00b1 50.82 ml\/ph\u00fat\/1.73 m\u00b2<\/p>\n\n\n\n<p>\u0110\u1ed1i ch\u1ee9ng: 44.46 \u00b1 12.60 ml\/ph\u00fat\/1.73 m\u00b2<\/p>\n\n\n\n<p>\u2192 C\u00e1c kh\u00e1c bi\u1ec7t n\u00e0y c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea (P &lt; 0.05).<\/p>\n\n\n\n<p>Ngo\u00e0i ra, kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 v\u1ec1 t\u1ef7 l\u1ec7 t\u00e1c d\u1ee5ng ph\u1ee5 gi\u1eefa hai nh\u00f3m.<\/p>\n\n\n\n<p>K\u1ebft lu\u1eadn (Conclusion)<\/p>\n\n\n\n<p>\u0110i\u1ec1u tr\u1ecb b\u1eb1ng c\u1ed1m c\u00f4ng th\u1ee9c th\u1ea3o d\u01b0\u1ee3c  trong 24 tu\u1ea7n c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng th\u1eadn \u1edf b\u1ec7nh nh\u00e2n CKD giai \u0111o\u1ea1n 3. Tuy nhi\u00ean protein ni\u1ec7u kh\u00f4ng gi\u1ea3m, n\u00ean \u00fd ngh\u0129a kh\u00f4ng \u0111\u01b0\u1ee3c t\u1ed1t l\u1eafm. C\u1ea7n c\u00f3 b\u00e0i thu\u1ed1c kh\u00e1c <\/p>\n\n\n\n<p>https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7596437<\/p>\n\n\n\n<p>Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng c\u1ee7a b\u00e0i thu\u1ed1c Th\u1eadn Tr\u1ecdc Ph\u01b0\u01a1ng (Shenzhuo Formula) trong \u0111i\u1ec1u tr\u1ecb albumin ni\u1ec7u n\u1eb7ng \u1edf b\u1ec7nh th\u1eadn do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u00e0 c\u01a1 ch\u1ebf \u0111i\u1ec1u h\u00f2a ph\u1ea3n \u1ee9ng vi\u00eam c\u1ee7a n\u00f3.<\/p>\n\n\n\n<p>B\u1ed1i c\u1ea3nh (Background)<\/p>\n\n\n\n<p>Shenzhuo Formula (SZF), m\u1ed9t b\u00e0i thu\u1ed1c c\u1ea3i bi\u00ean t\u1eeb Didang Tang, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb Diabetic Kidney Disease (b\u1ec7nh th\u1eadn do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng). Tuy nhi\u00ean, c\u00e1c b\u1eb1ng ch\u1ee9ng ch\u1ea5t l\u01b0\u1ee3ng cao v\u1ec1 hi\u1ec7u qu\u1ea3 c\u1ee7a b\u00e0i thu\u1ed1c n\u00e0y v\u1eabn c\u00f2n h\u1ea1n ch\u1ebf.<\/p>\n\n\n\n<p>Ph\u01b0\u01a1ng ph\u00e1p (Methods)<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u l\u00e0 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, \u0111a trung t\u00e2m, v\u1edbi thi\u1ebft k\u1ebf double-dummy v\u00e0 \u0111\u1ed1i ch\u1ee9ng ho\u1ea1t ch\u1ea5t.<\/p>\n\n\n\n<p>Thu\u1ed1c \u0111\u1ed1i ch\u1ee9ng l\u00e0 Irbesartan (IRB).<\/p>\n\n\n\n<p>Hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 b\u1eb1ng m\u00f4 h\u00ecnh th\u1ed1ng k\u00ea Bayesian.<\/p>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u c\u01a1 ch\u1ebf sinh h\u1ecdc bao g\u1ed3m:<\/p>\n\n\n\n<p>Ph\u00e2n t\u00edch proteomics vi\u00eam b\u1eb1ng c\u00f4ng ngh\u1ec7 Olink<\/p>\n\n\n\n<p>Gi\u1ea3i tr\u00ecnh t\u1ef1 RNA \u0111\u01a1n b\u00e0o (scRNA-seq) tr\u00ean th\u1eadn chu\u1ed9t KK-Ay<\/p>\n\n\n\n<p>C\u00e1c th\u00ed nghi\u1ec7m in vivo<\/p>\n\n\n\n<p>K\u1ebft qu\u1ea3 (Results)<\/p>\n\n\n\n<p>T\u1ed5ng c\u1ed9ng 120 b\u1ec7nh nh\u00e2n DKD c\u00f3 albumin ni\u1ec7u n\u1eb7ng \u0111\u01b0\u1ee3c ph\u00e2n nh\u00f3m ng\u1eabu nhi\u00ean:<\/p>\n\n\n\n<p>Nh\u00f3m SZF: 57 b\u1ec7nh nh\u00e2n<\/p>\n\n\n\n<p>Nh\u00f3m IRB: 63 b\u1ec7nh nh\u00e2n<\/p>\n\n\n\n<p>Sau 24 tu\u1ea7n:<\/p>\n\n\n\n<p>1. Protein ni\u1ec7u 24 gi\u1edd<\/p>\n\n\n\n<p>Nh\u00f3m SZF: \u22120.03 (\u22120.24 \u0111\u1ebfn 0.18) g\/24h<\/p>\n\n\n\n<p>Nh\u00f3m IRB: 0.08 (\u22120.30 \u0111\u1ebfn 0.14) g\/24h<\/p>\n\n\n\n<p>&#x27a1;&#xfe0f; Kh\u00f4ng c\u00f3 kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea (P = 0.61).<\/p>\n\n\n\n<p>2. Ch\u1ee9c n\u0103ng th\u1eadn<\/p>\n\n\n\n<p>estimated glomerular filtration rate (eGFR)<\/p>\n\n\n\n<p>SZF: t\u0103ng 5.91 mL\/ph\u00fat\/1.73m\u00b2<\/p>\n\n\n\n<p>IRB: gi\u1ea3m 1.67 mL\/ph\u00fat\/1.73m\u00b2<\/p>\n\n\n\n<p>P &lt; 0.01<\/p>\n\n\n\n<p>Creatinin huy\u1ebft thanh<\/p>\n\n\n\n<p>SZF: gi\u1ea3m 5.15 \u03bcmol\/L<\/p>\n\n\n\n<p>IRB: t\u0103ng 3.39 \u03bcmol\/L<\/p>\n\n\n\n<p>P &lt; 0.01<\/p>\n\n\n\n<p>3. \u0110\u00e1p \u1ee9ng h\u1ed9i ch\u1ee9ng theo y h\u1ecdc c\u1ed5 truy\u1ec1n<\/p>\n\n\n\n<p>SZF: 89.47%<\/p>\n\n\n\n<p>IRB: 63.49%<\/p>\n\n\n\n<p>&#x27a1;&#xfe0f; Kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea (P &lt; 0.01)<\/p>\n\n\n\n<p>4. An to\u00e0n<\/p>\n\n\n\n<p>T\u1ef7 l\u1ec7 t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 c\u00e1c ch\u1ec9 s\u1ed1 chuy\u1ec3n h\u00f3a t\u01b0\u01a1ng \u0111\u01b0\u01a1ng gi\u1eefa hai nh\u00f3m.<\/p>\n\n\n\n<p>Ph\u00e2n t\u00edch Bayesian cho th\u1ea5y SZF c\u00f3 l\u1ee3i th\u1ebf h\u01a1n v\u1ec1 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n\n\n\n<p>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng (Mechanism)<\/p>\n\n\n\n<p>B\u00e0i thu\u1ed1c SZF:<\/p>\n\n\n\n<p>Gi\u1ea3m bi\u1ec3u hi\u1ec7n CX3CL1 \u1edf t\u1ebf b\u00e0o n\u1ed9i m\u00f4<\/p>\n\n\n\n<p>Gi\u1ea3m MCP-1 \u1edf t\u1ebf b\u00e0o mesangial v\u00e0 t\u1ebf b\u00e0o \u1ed1ng th\u1eadn<\/p>\n\n\n\n<p>\u2192 G\u1ee3i \u00fd t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam, gi\u00fap:<\/p>\n\n\n\n<p>ph\u1ee5c h\u1ed3i ch\u1ee9c n\u0103ng n\u1ed9i m\u00f4<\/p>\n\n\n\n<p>gi\u1ea3m x\u01a1 h\u00f3a th\u1eadn.<\/p>\n\n\n\n<p>K\u1ebft lu\u1eadn (Conclusion)<\/p>\n\n\n\n<p>B\u00e0i thu\u1ed1c Shenzhuo Formula:<\/p>\n\n\n\n<p>T\u01b0\u01a1ng \u0111\u01b0\u01a1ng Irbesartan trong vi\u1ec7c gi\u1ea3m protein ni\u1ec7u<\/p>\n\n\n\n<p>T\u1ed1t h\u01a1n trong vi\u1ec7c b\u1ea3o t\u1ed3n ch\u1ee9c n\u0103ng th\u1eadn<\/p>\n\n\n\n<p>C\u1ea3i thi\u1ec7n tri\u1ec7u ch\u1ee9ng theo y h\u1ecdc c\u1ed5 truy\u1ec1n<\/p>\n\n\n\n<p>\u0110\u1ed9 an to\u00e0n t\u1ed1t<\/p>\n\n\n\n<p>T\u00e1c d\u1ee5ng c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn \u1ee9c ch\u1ebf ph\u1ea3n \u1ee9ng vi\u00eam qua tr\u1ee5c CX3CL1\/MCP-1.<\/p>\n\n\n\n<p>&#x1f4a1; M\u1ed9t \u0111i\u1ec3m r\u1ea5t \u0111\u00e1ng ch\u00fa \u00fd c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y (v\u1ec1 m\u1eb7t khoa h\u1ecdc):<\/p>\n\n\n\n<p>H\u1ecd kh\u00f4ng ch\u1ee9ng minh \u0111\u01b0\u1ee3c gi\u1ea3m protein ni\u1ec7u t\u1ed1t h\u01a1n thu\u1ed1c chu\u1ea9n,<\/p>\n\n\n\n<p>nh\u01b0ng l\u1ea1i cho th\u1ea5y c\u1ea3i thi\u1ec7n eGFR t\u1ed1t h\u01a1n.<\/p>\n\n\n\n<p>\u0110i\u1ec1u n\u00e0y khi\u1ebfn b\u00e0i nghi\u00ean c\u1ee9u n\u00e0y kh\u00e1 g\u00e2y tranh lu\u1eadn trong gi\u1edbi nghi\u00ean c\u1ee9u b\u1ec7nh th\u1eadn, v\u00ec trong DKD gi\u1ea3m albumin\/protein ni\u1ec7u th\u01b0\u1eddng l\u00e0 ch\u1ec9 d\u1ea5u quan tr\u1ecdng nh\u1ea5t c\u1ee7a b\u1ea3o v\u1ec7 th\u1eadn.<\/p>\n\n\n\n<p>https:\/\/academic.oup.com\/pcm\/article\/8\/4\/pbaf031\/8323138<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Ho\u00e0ng k\u1ef3 gi\u00fap gi\u1ea3m protein ni\u1ec7u r\u1ea5t m\u1ea1nh<\/strong><\/p>\n\n\n\n<p>https:\/\/pubmed.ncbi.nlm.nih.gov\/31034954<\/p>\n\n\n\n<p>Astragalus membranaceus (Ho\u00e0ng k\u1ef3) c\u00f3 ti\u1ec1m n\u0103ng mang l\u1ea1i l\u1ee3i \u00edch trong \u0111i\u1ec1u tr\u1ecb Diabetic Kidney Disease (b\u1ec7nh th\u1eadn do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng), m\u1ed9t b\u1ec7nh \u0111ang ng\u00e0y c\u00e0ng gia t\u0103ng nh\u01b0ng hi\u1ec7n v\u1eabn c\u00f3 \u00edt l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 kh\u1ea3 n\u0103ng b\u1ea3o v\u1ec7 th\u1eadn.<\/p>\n<!-- relpost-thumb-wrapper --><div class=\"relpost-thumb-wrapper\"><!-- filter-class --><div class=\"relpost-thumb-container\"><style>.relpost-block-single-image, .relpost-post-image { margin-bottom: 10px; 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